Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.0
5.9
Journals
Nutrients
Special Issues
Vitamins and Nutraceuticals in Muscle Tissue and Stem Cell Biology
share announcement

Vitamins and Nutraceuticals in Muscle Tissue and Stem Cell Biology

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: 25 May 2024 | Viewed by 7369

Special Issue Editor

Dr. Kenneth L. Seldeen

E-Mail Website
Guest Editor
University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
Interests: healthy aging; frailty; exercise; muscle biology; vitamin B3 supplement; nutrition supplement

Special Issue Information

Dear Colleagues,

Nutrition is a critical regulator across multiple organ systems, particularly to maintain healthy muscle function. Although the role of macronutrients is generally understood, the intricate interactions of vitamins and the diverse array of nutraceuticals in muscle biology are understudied. In light of surging increases in the number of older adults, identifying lifestyle adaptations such as nutrient supplementation will be important to maintain functional capacity and delay the onset of costly healthcare burdens. One such age-associated disease is sarcopenia, the loss of muscle mass and function with aging, which increases risk for early onset disability, loss of independence, and reduced quality of life. For example, identifying the importance of vitamin D for maintaining muscle homeostasis may provide evidence to support community-wide recommendations to maintain vitamin D sufficiency.

This Special Issue will publish either manuscripts describing original research or analytical reviews on the role of vitamins or nutraceuticals (such as resveratrol, tomatidine, ursolic acid, etc.) in skeletal muscle biology. Investigations and reviews may also examine the role of such nutrients in regulating physical performance, skeletal muscle mitochondria, inflammation, muscle satellite cells, and underlying muscle cell signaling.

Dr. Kenneth L. Seldeen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vitamin
  • nutraceutical
  • musculoskeletal health
  • sarcopenia
  • aging
  • mitochondria
  • inflammation
  • muscle satellite cells
  • atrophy
  • hypertrophy

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

12 pages, 3564 KiB  
Article
Vitamin A Promotes the Repair of Mice Skeletal Muscle Injury through RARα
by Wenjia Zhang, Qingyun Peng, Xiaoyu Zhang, Jiaxu Guo, Huili Tong and Shuang Li
Nutrients 2023, 15(17), 3674; https://doi.org/10.3390/nu15173674 - 22 Aug 2023
Cited by 1 | Viewed by 1280
Abstract
Vitamin A (VitA) is an important fat-soluble vitamin which plays an important role in cell growth and individual development. However, the effect of VitA on the repair process of muscle injury and its molecular mechanism are still unclear. In this study, VitA and [...] Read more.
Vitamin A (VitA) is an important fat-soluble vitamin which plays an important role in cell growth and individual development. However, the effect of VitA on the repair process of muscle injury and its molecular mechanism are still unclear. In this study, VitA and RA were first added to the culture medium of differentiated cells. We then detected cell differentiation marker proteins and myotube fusion. Moreover, the effects of VitA on RARα expression and nuclear translocation were further examined. The results showed that VitA significantly promoted the differentiation of C2C12, and the expression of RARα was significantly increased. Furthermore, VitA was injected into skeletal muscle injury in mice. HE staining and Western Blot results showed that VitA could significantly accelerate the repair of skeletal muscle injury and VitA increase the expression of RARα in mice. This study provides a theoretical basis for elucidating the regulation mechanism of VitA-mediated muscle development and the development of therapeutic drugs for muscle diseases in animals. Full article
(This article belongs to the Special Issue Vitamins and Nutraceuticals in Muscle Tissue and Stem Cell Biology)
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

14 pages, 1656 KiB  
Review
The Role of the Kynurenine Pathway in the Pathophysiology of Frailty, Sarcopenia, and Osteoporosis
by Juan Ballesteros, Daniel Rivas and Gustavo Duque
Nutrients 2023, 15(14), 3132; https://doi.org/10.3390/nu15143132 - 13 Jul 2023
Cited by 3 | Viewed by 3381
Abstract
Tryptophan is an essential nutrient required to generate vitamin B3 (niacin), which is mainly involved in energy metabolism and DNA production. Alterations in tryptophan metabolism could have significant effects on aging and musculoskeletal health. The kynurenine pathway, essential in tryptophan catabolism, is modulated [...] Read more.
Tryptophan is an essential nutrient required to generate vitamin B3 (niacin), which is mainly involved in energy metabolism and DNA production. Alterations in tryptophan metabolism could have significant effects on aging and musculoskeletal health. The kynurenine pathway, essential in tryptophan catabolism, is modulated by inflammatory factors that are increased in older persons, a process known as inflammaging. Osteoporosis, sarcopenia, osteosarcopenia, and frailty have also been linked with chronically increased levels of inflammatory factors. Due to the disruption of the kynurenine pathway by chronic inflammation and/or changes in the gut microbiota, serum levels of toxic metabolites are increased and are associated with the pathophysiology of those conditions. In contrast, anabolic products of this pathway, such as picolinic acid, have demonstrated a positive effect on skeletal muscle and bone. In addition, physical activity can modulate this pathway by promoting the secretion of anabolic kynurenines. According to the evidence collected, kynurenines could have a promising role as biomarkers for osteoporosis sarcopenia, osteosarcopenia, and frailty in older persons. In addition, some of these metabolites could become important targets for developing new pharmacological treatments for these conditions. Full article
(This article belongs to the Special Issue Vitamins and Nutraceuticals in Muscle Tissue and Stem Cell Biology)
►▼ Show Figures

Figure 1

12 pages, 1018 KiB  
Review
Effects of Vitamin D on Satellite Cells: A Systematic Review of In Vivo Studies
by Muhammad Subhan Alfaqih, Vita Murniati Tarawan, Nova Sylviana, Hanna Goenawan, Ronny Lesmana and Susianti Susianti
Nutrients 2022, 14(21), 4558; https://doi.org/10.3390/nu14214558 - 29 Oct 2022
Cited by 4 | Viewed by 2340
Abstract
The non-classical role of vitamin D has been investigated in recent decades. One of which is related to its role in skeletal muscle. Satellite cells are skeletal muscle stem cells that play a pivotal role in skeletal muscle growth and regeneration. This systematic [...] Read more.
The non-classical role of vitamin D has been investigated in recent decades. One of which is related to its role in skeletal muscle. Satellite cells are skeletal muscle stem cells that play a pivotal role in skeletal muscle growth and regeneration. This systematic review aims to investigate the effect of vitamin D on satellite cells. A systematic search was performed in Scopus, MEDLINE, and Google Scholar. In vivo studies assessing the effect of vitamin D on satellite cells, published in English in the last ten years were included. Thirteen in vivo studies were analyzed in this review. Vitamin D increases the proliferation of satellite cells in the early life period. In acute muscle injury, vitamin D deficiency reduces satellite cells differentiation. However, administering high doses of vitamin D impairs skeletal muscle regeneration. Vitamin D may maintain satellite cell quiescence and prevent spontaneous differentiation in aging. Supplementation of vitamin D ameliorates decreased satellite cells’ function in chronic disease. Overall, evidence suggests that vitamin D affects satellite cells’ function in maintaining skeletal muscle homeostasis. Further research is needed to determine the most appropriate dose of vitamin D supplementation in a specific condition for the optimum satellite cells’ function. Full article
(This article belongs to the Special Issue Vitamins and Nutraceuticals in Muscle Tissue and Stem Cell Biology)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop