Effect of Nutritional Conditions on Maternal and Infant Health in Different Periods of Gestation and Lactation

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: 5 June 2024 | Viewed by 854

Special Issue Editors


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Guest Editor
1. Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics, Biomarkers and Risk Evaluation Group), University of the Balearic Islands, 07122 Palma, Spain
2. Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma, Spain
3. CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute (ISCIII), 28029 Madrid, Spain
4. Alimentómica S.L. Camí de na Pontons. s/n (Pol.11, Parc 3), 07310 Campanet, Spain
Interests: perinatal nutrition; metabolic programming and regulation; obesity; diets; metabolic alterations; nutrigenomics; bioactive compounds
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics, Biomarkers and Risk Evaluation Group), University of the Balearic Islands, 07122 Palma, Spain
2. Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma, Spain
3. CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute (ISCIII), 28029 Madrid, Spain
4. Alimentómica S.L. Camí de na Pontons. s/n (Pol.11, Parc 3), 07310 Campanet, Spain
Interests: obesity; diets; metabolic alterations; nutrigenomics; nutrigenetics; bioactive compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pregnancy and lactation are critical developmental periods for determining the risk of chronic diseases in offspring, and nutritional status plays a vital role in the health of mother and baby. Maternal undernutrition during pregnancy is strongly associated with adverse infant programming, such as high risk of later diabetes devolvement. On the other hand, the high incidence of women of reproductive age with overweight and obesity is a main driver of the obesity pandemic, generating a cycle of obesity transmission from generation to generation. Besides gestation, lactation is another key window for metabolic programming. Breast milk can provide personalized nutrition and have short- and long-term health benefits for both baby and mother. However, the influence of certain maternal environments, particularly unbalanced diets and/or obesity, on milk composition and the effects for infant health have barely been explored.

For this Special Issue, we invite submissions of evidence-based manuscripts in both humans and animal models, reviews or meta-analyses focusing on the effect of nutritional conditions and dietary interventions during gestation and lactation on maternal and infant health. Works analysing the molecular mechanisms implicated are also welcome. Ultimately, we hope the content will be useful for clinical practitioners and inspire further innovative research.

Dr. Mariona Palou
Dr. Barbara Reynés
Guest Editors

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Keywords

  • gestation
  • lactation
  • dietary interventions
  • nutritional deficiency
  • unbalanced diets
  • maternal and infant health

Published Papers (1 paper)

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Research

19 pages, 5573 KiB  
Article
Brain-Derived Neurotrophic Factor as a Potential Mediator of the Beneficial Effects of Myo-Inositol Supplementation during Suckling in the Offspring of Gestational-Calorie-Restricted Rats
by Ana Valle, Pedro Castillo, Adrián García-Rodríguez, Andreu Palou, Mariona Palou and Catalina Picó
Nutrients 2024, 16(7), 980; https://doi.org/10.3390/nu16070980 - 27 Mar 2024
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Abstract
This study aims to investigate the potential mechanisms underlying the protective effects of myo-inositol (MI) supplementation during suckling against the detrimental effects of fetal energy restriction described in animal studies, particularly focusing on the potential connections with BDNF signaling. Oral physiological doses of [...] Read more.
This study aims to investigate the potential mechanisms underlying the protective effects of myo-inositol (MI) supplementation during suckling against the detrimental effects of fetal energy restriction described in animal studies, particularly focusing on the potential connections with BDNF signaling. Oral physiological doses of MI or the vehicle were given daily to the offspring of control (CON) and 25%-calorie-restricted (CR) pregnant rats during suckling. The animals were weaned and then fed a standard diet until 5 months of age, when the diet was switched to a Western diet until 7 months of age. At 25 days and 7 months of age, the plasma BDNF levels and mRNA expression were analyzed in the hypothalamus and three adipose tissue depots. MI supplementation, especially in the context of gestational calorie restriction, promoted BDNF secretion and signaling at a juvenile age and in adulthood, which was more evident in the male offspring of the CR dams than in females. Moreover, the CR animals supplemented with MI exhibited a stimulated anorexigenic signaling pathway in the hypothalamus, along with improved peripheral glucose management and enhanced browning capacity. These findings suggest a novel connection between MI supplementation during suckling, BDNF signaling, and metabolic programming, providing insights into the mechanisms underlying the beneficial effects of MI during lactation. Full article
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