Bioactive Natural and Synthetic Products in Human Health and Diseases: Basic, Preclinical and Clinical Studies—2nd Edition

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 30 December 2024 | Viewed by 966

Special Issue Editors

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Guest Editor
Department of Biology, College of Science Engineering and Technology, Jackson State University, 1400 JR Lynch St., Jackson, MS 39217, USA
Interests: molecular mechanisms of cancer development and metastasis; role of IGF2BP1 in the pathology of colorectal cancer and basal cell carcinoma; cancer cell fusion and breast tumor heterogeneity and metastasis; mRNA turnover and cancer development
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School of Clinical Sciences, College of Pharmacy, University of Louisiana Monroe, 1800 Bienville Drive, Monroe, LA 71201, USA
Interests: pharmacy practice; laboratory pedagogy and teaching styles; pharmaceutical compounding; natural products and formulation; compounding novel dosage forms for drug delivery; pharmacy practice clinical; educational and natural product research; health screening in under-privileged communities
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Guest Editor
Department of Biological Sciences and Chemistry, College of Sciences and Engineering, Southern University and A&M College, Baton Rouge, LA 70807, USA
Interests: skin health and diseases; carcinogenesis; inflammation; dermatology; psoriasis; atopic dermatitis; bioactive natural products; antioxidants; polyphenols; flavonoids; tissue engineering; signaling pathways; pharmacology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Homeostasis of the human body is guaranteed throughout life and across all ages via nature’s blessed natural dietary products or in their modified format as synthetic scaffold products that aid in boosting immunity, maintaining health, treating ailments or preventing disease occurrences or recurrences, and thus ensuring normal wellbeing. Biologically active natural and plant-derived, including fruits and vegetables, product preparations and synthetic scaffold products are garnering interest as valid human health-promoting, disease prevention, and management entities. Several of these bio-actives are antioxidants, polyphenols and other major medicinal entities that regulate vital physiological processes, including gene expression, protein synthesis, metabolism, differentiation and growth via mechanisms that are not well understood. Through epidemiological and intervention studies, several of these bioactives have been claimed and/or proven to offer protection against aging and health, oxidative stress, infection and several chronic inflammatory diseases such as acne, atopic dermatitis, cardiovascular diseases, hypertension, psoriasis, diabetes, diabetic ulcers, chronic wounds, various cancers, obesity and several associated risk factors. Moreover, cutting-edge research utilizing physiologically attainable doses in appropriate in vitro and preclinical model systems have provided some mechanistic insights on their benefits. Additionally, validating the health beneficial effects of nutraceuticals or pharmaceuticals and the detailed understanding of their intake, pharmacokinetics, pharmacodynamics, dose-response relationship and efficacy are thought-provoking, having complex relations, and such studies are warranted.

The purpose of this Special Issue is to update knowledge vis-à-vis the role of bioactive natural products from plants and dietary sources and synthetic scaffold compounds on human health and diseases such as the skin, other epithelial tissues like the breast, and other organ system diseases to shed light on the global relevance of scientific research findings on their usages. This may range from human health promotion, disease prevention and treatment, to reduction of adverse side effects, misuse and purposeless spending.

To help bridge the current knowledge gap, this Special Issue of Nutrients invites submission of manuscripts describing original research, communication, legislative documentations or quality reviews of scientific literature in skin and other organs’ health promotion and disease prevention and treatment. These conditions may include, but are not limited to, infection, oxidative stress, chronic inflammatory diseases including skin conditions such as acne, atopic dermatitis, psoriasis, diabetic wounds and various kind of cancers. Submissions addressing a broad range of topics, including studies covering bioavailability, understanding physiological functional processes, molecular targets, pathways and mechanisms of action from in vitro, preclinical animal models, human population and dietary intervention studies to impacts on human health, disease prevention and management, and advice on intake and usage, and their outcomes are welcome.

We look forward to your exciting submissions.

Dr. Felicite Noubissi-Kamdem
Dr. Anthony L. Walker
Dr. Jean Christopher Chamcheu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • acne, atopic dermatitis and psoriasis
  • antioxidants and phenolic compounds
  • breast cancer
  • chronic human diseases
  • bioavailability and bioactivity
  • skin beauty, aging and disease
  • infection, immunity and inflammation
  • cancer
  • natural dietary bioactives and food supplement
  • nutraceuticals and synthetic bioactive products
  • natural dietary product as alternative medicine
  • natural/synthetic bioactive agents for chemoprevention
  • human intervention trials
  • natural products, preclinical and clinical trials
  • natural and synthetic antimicrobials and immune-modulatory agents
  • phytonutrients for human health and disease

Published Papers (1 paper)

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11 pages, 745 KiB  
Increasing Natural Killer Cell Activity of Mineral Nanomaterial ALP1018 in Healthy Adults: A Randomized, Double-Blind, Placebo Comparative Clinical Trial
by Soon-Ae Kim, Seyl Kim, Hyungyung Chai, Junlae Cho and Yu-Jin Paek
Nutrients 2024, 16(6), 850; - 15 Mar 2024
Viewed by 797
This randomized, double-blind, placebo comparative clinical trial aimed to determine the immune-enhancing effects and safety of a nanomaterial with iron and zinc (ALP1018) in healthy adults. Participants who met the inclusion criteria were recruited for this study (n = 80) and randomly [...] Read more.
This randomized, double-blind, placebo comparative clinical trial aimed to determine the immune-enhancing effects and safety of a nanomaterial with iron and zinc (ALP1018) in healthy adults. Participants who met the inclusion criteria were recruited for this study (n = 80) and randomly assigned to either the test group (n = 40), which was given Alp1018 in capsule form, or the placebo group (n = 40), which was given crystal cellulose capsules of identical appearance, weight, and flavor for 8 weeks. Compared to baseline, natural killer (NK) cell activity (%) increased in the test group after 8 weeks, although there were no changes in the placebo group. Furthermore, in the subgroup analysis of Coronavirus disease 2019 (COVID-19) affected participants, significantly increased NK cell activity was observed in the test group at 4 (p < 0.05) and 8 weeks (p < 0.05). No significant differences were observed in cytokine levels between the two groups. ALP1018 supplementation appeared to enhance immune function by improving NK cell activity without adverse effects in healthy adults. Full article
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