Polyphenols and Plant Extracts for the Prevention of Cancer

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 5 July 2024 | Viewed by 1093

Special Issue Editor


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Guest Editor
Department of Public Health Medicine, Medical School, University of Pẻcs, 7621 Pẻcs, Hungary
Interests: cancer; gene expression; polyphenols; plant extract; chemoprevention; molecular epidemiology

Special Issue Information

Dear Colleagues,

Tumor diseases are claiming more and more victims worldwide. Cancer is the leading cause of death worldwide; it was responsible for nearly 10 million deaths in recent years. Therefore, in addition to therapeutic intervention for cancer diseases, prevention plays an important role. As a part of primary prevention, phytochemicals are capable of preventing, delaying, or reversing the initiation, promotion, and progression of preneoplastic cells into cancerous cells, thus reducing the incidence of cancerous diseases. These compounds also play a role in tertiary prevention, and they can influence the formation of metastasis through different molecular pathways, thus reducing mortality in the long term. Therefore, this Special Issue prioritizes studies that discuss the chemoprevention of cancer diseases using phytochemicals of plant origin. It searches for evidence on the mechanisms of action of bioactive agents in fruits, vegetables, and plant extracts, such as polyphenols, through experiments on specific cell lines, animal models, and human studies.

Our goal is to highlight plant-derived compounds that are important for tumor prevention and to introduce new research results to the scientific community. This Special Issue focuses on the investigation of compounds and plant extracts using molecular biological methods, epigenetics, and human epidemiological studies.

We invite your research group to submit summaries of their original studies on this important, current topic.

Dr. Tímea Varjas
Guest Editor

Manuscript Submission Information

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Keywords

  • chemoprevention
  • plant extract
  • animal model
  • in vivo model
  • in vitro study
  • messenger RNA expression
  • miRNA expression
  • blocking agent
  • suppressing agent
  • apoptosis

Published Papers (1 paper)

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Research

15 pages, 2333 KiB  
Article
Betanin Attenuates Epigenetic Mechanisms and UV-Induced DNA Fragmentation in HaCaT Cells: Implications for Skin Cancer Chemoprevention
by Afshin Zand, Sodbuyan Enkhbilguun, John M. Macharia, Krisztina Varajti, Istvan Szabó, Gellért Gerencsér, Boglárka Bernadett Tisza, Bence L. Raposa, Zoltán Gyöngyi and Timea Varjas
Nutrients 2024, 16(6), 860; https://doi.org/10.3390/nu16060860 - 16 Mar 2024
Viewed by 885
Abstract
Dermal photoaging refers to the skin’s response to prolonged and excessive ultraviolet (UV) exposure, resulting in inflammation, changes to the tissue, redness, swelling, and discomfort. Betanin is the primary betacyanin in red beetroot (Beta vulgaris) and has excellent antioxidant properties. Yet, [...] Read more.
Dermal photoaging refers to the skin’s response to prolonged and excessive ultraviolet (UV) exposure, resulting in inflammation, changes to the tissue, redness, swelling, and discomfort. Betanin is the primary betacyanin in red beetroot (Beta vulgaris) and has excellent antioxidant properties. Yet, the specific molecular mechanisms of betanin in HaCaT cells have not been fully clarified. The objective of this study was to investigate the activity of betanin and the underlying mechanisms in HaCaT cells; furthermore, in this study, we explored the protective effect of various concentrations of betanin against UVB irradiation on HaCaT cells. Additionally, we assessed its influence on the transcription of various epigenetic effectors, including members of the DNA methyltransferase (DNMT) and histone deacetylase (HDAC) families. Our findings demonstrate a notable downregulation of genes in HaCaT cells, exhibiting diverse patterns upon betanin intake. We considered the involvement of DNMT and HDAC genes in distinct stages of carcinogenesis and the limited exploration of the effects of daily exposure dosages. Our results indicate that betanin may protect the skin from damage caused by UV exposure. Further investigation is essential to explore these potential associations. Full article
(This article belongs to the Special Issue Polyphenols and Plant Extracts for the Prevention of Cancer)
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