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Metabolic Syndrome: The Causative Role of High-Fat Diet and the Assistance from Nutrients and Intestinal Microbiota

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (5 April 2024) | Viewed by 1329

Special Issue Editors


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Guest Editor
Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10 Tuwima Street, 10-718 Olsztyn, Poland
Interests: gut microbiota activity; metabolism; in vivo experiments; nutrition; oxidative stress; inflammation
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10 Tuwima Street, 10-718 Olsztyn, Poland
Interests: in vivo experiments; nutrition; oxidative stress; inflammation; obesity; liver disorders; gut-microbiota-derived metabolites; metabolic disorders; interaction between the gut and liver
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is our pleasure to announce the launch of a new Special Issue of the journal Nutrients, entitled  “Metabolic Syndrome: The Causative Role of High-Fat Diet and the Assistance from Nutrients and Intestinal Microbiota”.

It is well known that some of the metabolic disorders that occur in developed countries result from well-established, faulty eating habits. People have begun to understand that diets rich in fats, mostly saturated fatty acids and carbohydrates, and low in dietary fibre increase the risk of obesity, type 2 diabetes and cardiovascular diseases and, thus, the occurrence of metabolic syndrome. Most dietary-related disorders are associated with changes in the activity and profile of gut microbiota. These microorganisms have the potential to produce bioactive compounds that may signal to the host by activating cognate receptors in various cells. These molecules activate receptors in the gut, liver and periphery to regulate several host molecular mechanisms, including processes related to metabolic disorders. Therefore, the specific regulation of the activity and/or profile of gut microbiota, combined with specific eating habits, can play a paramount role in the prevention and mitigation of disorders related to metabolic syndrome.

The aim of this Special Issue is to provide new insights into the relations between dietary habits (main and minor nutrients), local microbiota action in the gastrointestinal tract and systemic responses of an organism developing metabolic syndrome through changes in the mechanisms associated with lipid, carbohydrates metabolism, inflammation and antioxidant status.

In this Special Issue, original research and literature reviews concerning the interplay between diets that are rich in fat and associated dietary-mitigating treatments, gut microbiota and metabolic syndrome disorders will be appreciated.

We look forward to receiving your contributions.

Prof. Dr. Jerzy Juśkiewicz
Dr. Bartosz Fotschki
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • high-fat diet
  • obesity and dietary therapy
  • type 2 diabetes
  • cardiovascular diseases
  • metabolic disorders
  • lipid metabolism
  • inflammation
  • oxidative stress
  • blood lipid profile
  • gut microbiota
  • gut microbial activity
  • gut-microbiota-derived metabolites

Published Papers (1 paper)

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Research

17 pages, 6708 KiB  
Article
Effect of Chromium Nanoparticles and Switching from a High-Fat to a Low-Fat Diet on the Cecal Microenvironment in Obese Rats
by Bartosz Fotschki, Katarzyna Ognik, Ewelina Cholewińska, Katarzyna Grzelak-Błaszczyk, Kamil Myszczyński, Magdalena Krauze and Jerzy Juśkiewicz
Nutrients 2023, 15(14), 3118; https://doi.org/10.3390/nu15143118 - 12 Jul 2023
Cited by 3 | Viewed by 1007
Abstract
Previous studies showed that chromium nanoparticles (Cr-NPs) might be used as dietary compounds against some obesity-related disorders; however, there is little information on how these compounds influence the gut microenvironment. The aim of this study was to investigate whether the negative effects of [...] Read more.
Previous studies showed that chromium nanoparticles (Cr-NPs) might be used as dietary compounds against some obesity-related disorders; however, there is little information on how these compounds influence the gut microenvironment. The aim of this study was to investigate whether the negative effects of a high-fat diet in the large intestine of rats might be mitigated by switching to a low-fat diet and supplementation with Cr-NPs. Microbiota sequencing analysis revealed that the main action of the Cr-NPs was focused on changing the gut microbiota’s activity. Supplementation with nanoparticles decreased the activity of β-glucuronidase and enzymes responsible for the hydrolysis of dietary oligosaccharides and, thus, lowered the concentration of short-chain fatty acids in the cecum. In this group, there was also an elevated level of cecal lithocholic acid. The most favorable effect on the regulation of obesity-related disorders was observed when a high-fat diet was switched to a low-fat diet. This dietary change enhanced the production of short-chain fatty acids, reduced the level of secondary bile acids, and increased the microbial taxonomic richness, microbial differences, and microbial enzymatic activity in the cecum. To conclude, supplementation of a high-fat diet with Cr-NPs primarily had an effect on intestinal microbial activity, but switching to a low-fat diet had a powerful, all-encompassing effect on the gut that improved both microbial activity and composition. Full article
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