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Nutrients
Special Issues
Effect of Dietary Natural Products on Diabetes and Its Complications
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Effect of Dietary Natural Products on Diabetes and Its Complications

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Diabetes".

Deadline for manuscript submissions: 5 May 2024 | Viewed by 3077

Special Issue Editors

Dr. Lina Yang

E-Mail Website
Guest Editor
Department of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, Changsha 410008, China
Interests: natural products; diabetes; liver and kidney injury
Dr. Jihua Chen

E-Mail Website
Guest Editor
Department of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, Changsha 410008, China
Interests: natural products; nutrients; diseases
Dr. Weiwei Cui

E-Mail Website
Guest Editor
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, China
Interests: natural products; nutrients; diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The prevalence of diabetes mellitus is increasing worldwide, representing one of the current most serious public health problems. In particular, diabetes complications, such as diabetic nephropathy, diabetic liver damage, diabetic eye disease, etc., significantly affect people's quality of life and result in a heavy burden for individuals, families, and society.

Recent studies have found that natural products have protective effects and nutritional potential for protection against diabetes and its complications. A variety of natural dietary products and their bioactive components have shown effects on the prevention and treatment of diabetes by regulating gut microbiota composition and abundance, the change in gut permeability, the production of short-chain fatty acids, and the inhibition of inflammation.

This Special Issue invites researchers to contribute original research and review articles focused on the nutritional potential of natural products for diabetes and its multiple complications.

Dr. Lina Yang
Dr. Jihua Chen
Dr. Weiwei Cui
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural dietary products
  • nutrition
  • diabetes
  • diabetes nephropathy
  • diabetes liver damage
  • diabetes eye disease
  • mechanism

Published Papers (2 papers)

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Research

13 pages, 1894 KiB  
Article
Effects of Gestational Diabetes Mellitus and Selenium Deficiency on the Offspring Growth and Blood Glucose Mechanisms of C57BL/6J Mice
by Wenhui Xu, Jiayu Gong, Yifei Chen, Yiru Chen, Shutong Chen, Yanyan Wu, Yuan He, Chenxu Li, Haitao Yu and Lin Xie
Nutrients 2023, 15(21), 4519; https://doi.org/10.3390/nu15214519 - 25 Oct 2023
Cited by 2 | Viewed by 1016
Abstract
This study aimed to explore the effects and mechanisms of maternal gestational diabetes mellitus (GDM) and selenium (Se) deficiency on the growth and glucose metabolism of offspring. Female C57BL/6J mice were divided into four groups as follows: a control group, a GDM group, [...] Read more.
This study aimed to explore the effects and mechanisms of maternal gestational diabetes mellitus (GDM) and selenium (Se) deficiency on the growth and glucose metabolism of offspring. Female C57BL/6J mice were divided into four groups as follows: a control group, a GDM group, a Se deficiency group, and a GDM with Se deficiency group. GDM animal models were established via S961. Pregnant mice fed their offspring until weaning. Then, offspring continued to be fed with a basic diet until adulthood. Body weight and fasting blood glucose were measured weekly. Se content, oxidative stress indicators, and the protein expression of the PI3K/Akt signaling pathway were detected. GDM increased susceptibility to obesity in lactating offspring, with gender differences observed in adult offspring. The effect of Se deficiency on SOD activity only appeared in female offspring during adulthood but was shown in male offspring during weaning though it disappeared during adulthood. GDM and Se deficiency increased the risk of abnormal glucose metabolism in female offspring from weaning to adulthood but gradually decreased in male offspring. The influence on the expression of PI3K/Akt signaling pathway-related proteins showed the same trend. GDM and Se deficiency affected the growth and glucose metabolism of offspring through oxidative stress and PI3K/Akt signaling pathway-related proteins, and gender differences existed. Full article
(This article belongs to the Special Issue Effect of Dietary Natural Products on Diabetes and Its Complications)
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15 pages, 989 KiB  
Article
Glycemic Variability in Patients with Type 2 Diabetes Mellitus (T2DM): The Role of Melatonin in a Crossover, Double-Blind, Placebo-Controlled, Randomized Study
by Wagner Martorina and Almir Tavares
Nutrients 2023, 15(16), 3523; https://doi.org/10.3390/nu15163523 - 10 Aug 2023
Cited by 1 | Viewed by 1506
Abstract
Background: Glycemic variability in patients with type 2 diabetes mellitus (T2DM) may be associated with chronic complications of the disease. Melatonin is a hormone that plays a crucial role in biological rhythms. Previous studies have indicated that individuals with T2DM often exhibit reduced [...] Read more.
Background: Glycemic variability in patients with type 2 diabetes mellitus (T2DM) may be associated with chronic complications of the disease. Melatonin is a hormone that plays a crucial role in biological rhythms. Previous studies have indicated that individuals with T2DM often exhibit reduced melatonin production. In this study, our objective was to investigate whether nighttime melatonin supplementation could mitigate glycemic variability in these patients. Methods: Crossover, double-blind, placebo-controlled, randomized study. A total of 30 patients were enrolled in this study. The study included 15 participants who followed the intervention sequence of placebo (7 days)—washout (7 days)—melatonin (3 mg) (7 days), and another 15 participants who followed the sequence of melatonin (3 mg) (7 days)—washout (7 days)—placebo (7 days). During the final three days of the first and third weeks, the participants measured their pre- and postprandial capillary blood glucose levels. This study was reported according to the CONSORT 2010 statement: extension to randomized crossover trials. Results: There was a significant absolute difference in the breakfast blood glucose levels (p = 0.016) on Day 7. The use of melatonin determined a greater positive variation between pre- and postprandial glycemia than the placebo. The difference in glycemic amplitude between post-dinner Day 6 and pre-breakfast Day 7 was also significantly higher in the melatonin group (p = 0.032). Conclusions: Melatonin increased glycemic variability in individuals with type 2 diabetes mellitus (T2DM). These results can be attributed to the residual daytime effects of melatonin, prospective proximal effects, and damage to the prospective distal effects of exogenous melatonin. Therefore, caution should be exercised when administering melatonin supplementation to patients with T2DM, taking into consideration factors such as dosage, duration of use and genetic considerations. Full article
(This article belongs to the Special Issue Effect of Dietary Natural Products on Diabetes and Its Complications)
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