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Nutrients
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Research Progress of Natural Antioxidants in Neurodegenerative Diseases
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Research Progress of Natural Antioxidants in Neurodegenerative Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 8699

Special Issue Editors

Dr. Muhammad Ajmal Shah

E-Mail Website
Guest Editor
Department of Pharmacy, Hazara University, Mansehra, Pakistan
Interests: green extraction and enrichement of biaoctive compounds; nutraceuticals; antidiabetic; antidiabesitic; neuroprotection; anti-Alzheimer; anti-Parkinson’s
Prof. Dr. Anna Maria Witkowska

E-Mail Website
Co-Guest Editor
Department of Food Biotechnology, Faculty of Health Sciences, Medical University of Bialystok, Bialystok, Poland
Interests: bioactive compounds; polyphenols; dietary antioxidants; oxidative stress; nutrition; food; nutritional epidemiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nutrients’ Special Issue “Research Progress of Natural Antioxidants in Neurodegenerative Diseases”, addresses the importance of antioxidant intake for brain health. Once absorbed into the blood and transported into the brain, antioxidants can help and reduce oxidative stress to brain cells. Thus, natural products including plants extracts, phytochemicals, and nutraceuticals with antioxidant potential are unique preventive and therapeutic agents for neurodegenerative disorders.

This Special Issue is open to research on the development, progression and management of neurodegenerative diseases, including Alzheimer's, Huntington's, Parkinson's, ALS, epilepsy, depression, memory loss and the neuroprotective effects of antioxidants.

Natural compounds that contain antioxidant molecules have neuroprotective effects that help and protect the brain from radical damage that affects brain cells.

Dr. Muhammad Ajmal Shah
Dr. Anna Maria Witkowska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant natural products
  • neuroprotection
  • nutraceuticals
  • phytomedicine
  • anti-Alzheimer's
  • anti-Huntington's
  • anti-Parkinson's
  • anti-epileptic
  • anti-depressant
  • memory enhancement

Published Papers (3 papers)

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Research

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10 pages, 2287 KiB  
Communication
Taxifolin Suppresses Inflammatory Responses of High-Glucose-Stimulated Mouse Microglia by Attenuating the TXNIP–NLRP3 Axis
by Masayo Iwasa, Hisashi Kato, Kaori Iwashita, Hajime Yamakage, Sayaka Kato, Satoshi Saito, Masafumi Ihara, Hideo Nishimura, Atsuhiko Kawamoto, Takayoshi Suganami, Masashi Tanaka and Noriko Satoh-Asahara
Nutrients 2023, 15(12), 2738; https://doi.org/10.3390/nu15122738 - 13 Jun 2023
Cited by 6 | Viewed by 1882
Abstract
Type 2 diabetes mellitus is associated with an increased risk of dementia, potentially through multifactorial pathologies, including neuroinflammation. Therefore, there is a need to identify novel agents that can suppress neuroinflammation and prevent cognitive impairment in diabetes. In the present study, we demonstrated [...] Read more.
Type 2 diabetes mellitus is associated with an increased risk of dementia, potentially through multifactorial pathologies, including neuroinflammation. Therefore, there is a need to identify novel agents that can suppress neuroinflammation and prevent cognitive impairment in diabetes. In the present study, we demonstrated that a high-glucose (HG) environment elevates the intracellular reactive oxygen species (ROS) levels and triggers inflammatory responses in the mouse microglial cell line BV-2. We further found that thioredoxin-interacting protein (TXNIP), a ROS-responsive positive regulator of the nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, was also upregulated, followed by NLRP3 inflammasome activation and subsequent interleukin-1beta (IL-1β) production in these cells. Conversely, caspase-1 was not significantly activated, suggesting the involvement of noncanonical pathways in these inflammatory responses. Moreover, our results demonstrated that taxifolin, a natural flavonoid with antioxidant and radical scavenging activities, suppressed IL-1β production by reducing the intracellular ROS levels and inhibiting the activation of the TXNIP–NLRP3 axis. These findings suggest the novel anti-inflammatory effects of taxifolin on microglia in an HG environment, which could help develop novel strategies for suppressing neuroinflammation in diabetes. Full article
(This article belongs to the Special Issue Research Progress of Natural Antioxidants in Neurodegenerative Diseases)
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28 pages, 6295 KiB  
Article
Long-Term Supplementation of Syzygium cumini (L.) Skeels Concentrate Alleviates Age-Related Cognitive Deficit and Oxidative Damage: A Comparative Study of Young vs. Old Mice
by Nosheen Malik, Sana Javaid, Waseem Ashraf, Farhan Siddique, Muhammad Fawad Rasool, Faleh Alqahtani, Tanveer Ahmad, Muhammad Asad Abrar and Imran Imran
Nutrients 2023, 15(3), 666; https://doi.org/10.3390/nu15030666 - 28 Jan 2023
Cited by 8 | Viewed by 3032
Abstract
The Syzygium cumini (L.) Skeels is reported to have medicinal properties, but its benefits on age-related neurological changes have not been previously explored. In the current study, after phytochemical analysis of the pulp of Syzygium cumini (L.) Skeels fruit (Sy. cmi), [...] Read more.
The Syzygium cumini (L.) Skeels is reported to have medicinal properties, but its benefits on age-related neurological changes have not been previously explored. In the current study, after phytochemical analysis of the pulp of Syzygium cumini (L.) Skeels fruit (Sy. cmi), young BALB/c mice have been supplemented with its 5, 15, and 30% dilution for 16 months, followed by behavioral experimentation and biochemical evaluation of isolated brains. The Sy. cmi has been found enriched with phenols/flavonoids while the occurrence of nine phytocompounds has been identified through GC-MS analysis. Further, Sy. cmi supplementation has caused significant (p < 0.05) protection from anxiety-like behavior in aged mice, and they have explored open, illuminated, and exposed areas of open field, light/dark, and an elevated plus maze, respectively. Furthermore, these animals have shown improved cognitive abilities as their percent (%) spontaneous alteration and novelty preference are significantly greater in T-maze and Y-maze and familiarity/novelty recognition tests. Further, Sy. cmi-supplemented mice remember the aversive stimuli zone and escape box location in passive avoidance and Barnes maze tests, and their brains have low levels of malondialdehyde and acetylcholinesterase with elevated antioxidant enzymes. The outcomes have provided scientific insight into the beneficial effects of Sy. cmi on age-associated amnesia that might be attributed to antioxidant and anticholinergic effects exerted by phytocompounds (caryophyllene, humulene, β-Farnesene, and phytol) owned by Syzygium cumini. Full article
(This article belongs to the Special Issue Research Progress of Natural Antioxidants in Neurodegenerative Diseases)
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Review

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19 pages, 918 KiB  
Review
A Triterpenoid Lupeol as an Antioxidant and Anti-Neuroinflammatory Agent: Impacts on Oxidative Stress in Alzheimer’s Disease
by Jun Sung Park, Inayat Ur Rehman, Kyonghwan Choe, Riaz Ahmad, Hyeon Jin Lee and Myeong Ok Kim
Nutrients 2023, 15(13), 3059; https://doi.org/10.3390/nu15133059 - 7 Jul 2023
Cited by 5 | Viewed by 2983
Abstract
Alzheimer’s disease (AD) is the most common neurodegenerative disease illustrated by neuronal dysfunctions, leading to memory weaknesses and personality changes mostly in the aged population worldwide. The exact cause of AD is unclear, but numerous studies have addressed the involvement of oxidative stress [...] Read more.
Alzheimer’s disease (AD) is the most common neurodegenerative disease illustrated by neuronal dysfunctions, leading to memory weaknesses and personality changes mostly in the aged population worldwide. The exact cause of AD is unclear, but numerous studies have addressed the involvement of oxidative stress (OS), induced by reactive oxygen species (ROS), to be one of the leading causes in developing AD. OS dysregulates the cellular homeostasis, causing abnormal protein and lipid metabolism. Nutrition plays a pivotal role in modulating the antioxidant system and decreases the neuronal ROS level, thus playing an important therapeutic role in neurodegenerative diseases, especially in AD. Hence, medicinal herbs and their extracts have received global attention as a commercial source of antioxidants Lupeol. Lupeol is a pentacyclic triterpenoid and has many biological functions. It is available in fruits, vegetables, and medicinal plants. It has shown effective antioxidant and anti-inflammatory properties, and higher blood–brain barrier permeability. Also, the binding and inhibitory potentials of Lupeol have been investigated and proved to be effective against certain receptor proteins and enzymes in AD studies by computational molecular docking approaches. Therefore, AD-related research has gained interest in investigating the therapeutic effects of Lupeol. However, despite its beneficial effects in AD, there is still a lack of research in Lupeol. Hence, we compiled in this analysis all preclinical research that looked at Lupeol as an antioxidant and anti-inflammatory agent for AD. Full article
(This article belongs to the Special Issue Research Progress of Natural Antioxidants in Neurodegenerative Diseases)
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