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Nutrients
Special Issues
Targeting the Gut Microbiota in Metabolic Disease
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Targeting the Gut Microbiota in Metabolic Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 5 August 2024 | Viewed by 4436

Special Issue Editor

Dr. Leni Rose Rivera

E-Mail Website
Guest Editor
Faculty of Health, School of Medicine, Geelong Waurn Ponds Campus, Deakin University, Waurn Ponds, Australia
Interests: gut health; gut microbiome; obesity; AGEs; NAFLD; diet
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The gastrointestinal tract plays host to an extraordinarily abundant and diverse community of microorganisms, collectively known as the gut microbiota. This community of microbes influences many systems of the body and has a profound effect on human metabolism. Existing evidence in studies from both animals and humans supports a link between the gut microbiome and metabolic disorders including obesity, non-alcoholic fatty liver disease, type 2 diabetes mellitus, metabolic syndrome, as well as cardio-metabolic disease. Given the increasing prevalence of metabolic disorders globally, it is important to determine how the gut microbiota and its derived metabolites are altered in metabolic disorders and the role they play in disease pathogenesis. This Special Issue will delve into exploring the important relationship between the gut microbiota and metabolic disorders.

Dr. Leni Rose Rivera
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiome
  • obesity
  • diabetes
  • metabolic syndrome
  • cardio-metabolic diseases
  • non-alcoholic fatty liver disease
  • gut health
  • diet

Published Papers (2 papers)

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Research

20 pages, 7355 KiB  
Article
Effects of Synbiotic Supplementation on Metabolic Syndrome Traits and Gut Microbial Profile among Overweight and Obese Hong Kong Chinese Individuals: A Randomized Trial
by Susana Lauw, Nelson Kei, Po Lam Chan, Tsz Kwan Yau, Ka Lee Ma, Carol Ying Ying Szeto, Janice Su-Chuen Lin, Sunny Hei Wong, Peter Chi Keung Cheung and Hoi Shan Kwan
Nutrients 2023, 15(19), 4248; https://doi.org/10.3390/nu15194248 - 02 Oct 2023
Cited by 1 | Viewed by 2574
Abstract
In view of the limited evidence showing anti-obesity effects of synbiotics via modulation of the gut microbiota in humans, a randomized clinical trial was performed. Assessment of the metabolic syndrome traits and profiling of the fecal gut microbiota using 16S rRNA gene sequencing [...] Read more.
In view of the limited evidence showing anti-obesity effects of synbiotics via modulation of the gut microbiota in humans, a randomized clinical trial was performed. Assessment of the metabolic syndrome traits and profiling of the fecal gut microbiota using 16S rRNA gene sequencing in overweight and obese Hong Kong Chinese individuals before and after dietary intervention with an 8-week increased consumption of fruits and vegetables and/or synbiotic supplementation was conducted. The selected synbiotic contained two probiotics (Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019) and a prebiotic (polydextrose). Fifty-five overweight or obese individuals were randomized and divided into a synbiotic group (SG; n = 19), a dietary intervention group (DG; n = 18), and a group receiving combined interventions (DSG; n = 18). DSG showed the greatest weight loss effects and number of significant differences in clinical parameters compared to its baseline values—notably, decreases in fasting glucose, insulin, HOMA-IR, and triglycerides and an increase in HDL-cholesterol. DSG lowered Megamonas abundance, which was positively associated with BMI, body fat mass, and trunk fat mass. The results suggested that increasing dietary fiber consumption from fruits and vegetables combined with synbiotic supplementation is more effective than either approach alone in tackling obesity. Full article
(This article belongs to the Special Issue Targeting the Gut Microbiota in Metabolic Disease)
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17 pages, 2763 KiB  
Article
Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients
by Álvaro Pérez-Rubio, Polina Soluyanova, Erika Moro, Guillermo Quintás, Iván Rienda, María Dolores Periañez, Andrés Painel, José Vizuete, Judith Pérez-Rojas, José V. Castell, Ramón Trullenque-Juan, Eugenia Pareja and Ramiro Jover
Nutrients 2023, 15(14), 3187; https://doi.org/10.3390/nu15143187 - 18 Jul 2023
Cited by 3 | Viewed by 1372
Abstract
Bariatric surgery (BS) has several benefits, including resolution of non-alcoholic fatty liver disease (NAFLD) in many patients. However, a significant percentage of patients do not experience improvement in fatty liver after BS, and more than 10% develop new or worsening NAFLD features. Therefore, [...] Read more.
Bariatric surgery (BS) has several benefits, including resolution of non-alcoholic fatty liver disease (NAFLD) in many patients. However, a significant percentage of patients do not experience improvement in fatty liver after BS, and more than 10% develop new or worsening NAFLD features. Therefore, a question that remains unanswered is why some patients experience resolved NAFLD after BS and others do not. In this study, we investigated the fecal microbiota and plasma bile acids associated with NAFLD resolution in twelve morbidly obese patients undergoing BS, of whom six resolved their steatosis one year after surgery and another six did not. Results indicate that the hallmark of the gut microbiota in responder patients is a greater abundance of Bacteroides, Akkermansia, and several species of the Clostridia class (genera: Blautia, Faecalibacterium, Roseburia, Butyricicoccusa, and Clostridium), along with a decreased abundance of Actinomycetes/Bifidobacterium and Faecalicatena. NAFLD resolution was also associated with a sustained increase in primary bile acids (particularly non-conjugated), which likely results from a reduction in bacterial gut species capable of generating secondary bile acids. We conclude that there are specific changes in gut microbiota and plasma bile acids that could contribute to resolving NAFLD in BS patients. The knowledge acquired can help to design interventions with prebiotics and/or probiotics to promote a gut microbiome that favors NAFLD resolution. Full article
(This article belongs to the Special Issue Targeting the Gut Microbiota in Metabolic Disease)
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