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Early Life Nutrition and Fetal Health
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Early Life Nutrition and Fetal Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Pediatric Nutrition".

Deadline for manuscript submissions: closed (20 November 2023) | Viewed by 4763

Special Issue Editor

Dr. Jin-Ran Chen

E-Mail Website
Guest Editor
Arkansas Children’s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Interests: maternal and postanal early life nutrition; bone development; gestational; lactational and pediatric bone loss; dietary factors; phenolic acids; epigenetics; DNA methylation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The first five years of life are the period when dietary behaviors that promote optimal nutrition, growth and development are established or begin to be tracked throughout the lifespan. Maternal nutritional status in the embryonic and fetal stages and childhood nutritional status in infancy and early childhood can significantly affect child development and health.

During these sensitive developmental periods, disturbances in nutritional quality increase the risk of common adult diseases, such as obesity, metabolic syndrome, osteopenia, cardiovascular disease, non-alcoholic fatty liver disease, cognitive function, and neuropsychological disorders. Therefore, early life nutrition planning has become a hot research topic.

This Special Issue calls for original research or review articles focusing on how early life nutrition affects tissue development, growth, and function in children. Early exposure to phytonutrients (e.g., from blueberries or soy), or breastfeeding versus formula feeding, was considered in both animal models and human cohorts. Manuscripts on the mechanisms by which obesity and high-fat diets (in mothers and their offspring) may contribute to poor bone health are equally welcome.

Dr. Jin-Ran Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • early life nutrition
  • dietary behaviors
  • development
  • growth
  • breastfeeding

Published Papers (2 papers)

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Research

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16 pages, 298 KiB  
Article
Association of Maternal Folate Intake and Offspring MTHFD1 and MTHFD2 Genes with Congenital Heart Disease
by Hanjun Liu, Jun Ou, Yige Chen, Qian Chen, Manjun Luo, Tingting Wang and Jiabi Qin
Nutrients 2023, 15(16), 3502; https://doi.org/10.3390/nu15163502 - 09 Aug 2023
Cited by 2 | Viewed by 1289
Abstract
Existing evidence supported that congenital heart defect (CHD) was associated with a combination of environmental and genetic factors. Based on this, this study aimed at assessing the association of maternal folic acid supplementation (FAS), genetic variations in offspring methylenetetrahydrofolate dehydrogenase (MTHFD)1 and MTHFD2 [...] Read more.
Existing evidence supported that congenital heart defect (CHD) was associated with a combination of environmental and genetic factors. Based on this, this study aimed at assessing the association of maternal folic acid supplementation (FAS), genetic variations in offspring methylenetetrahydrofolate dehydrogenase (MTHFD)1 and MTHFD2 genes, and their interactions with CHD and its subtypes. A hospital-based case–control study, including 620 cases with CHD and 620 healthy children, was conducted. This study showed that the absence of FAS was significantly associated with an increased risk of total CHD and its subtypes, such as atrial septal defect (ASD). FAS during the first and second trimesters was associated with a significantly higher risk of CHD in offspring compared to FAS during the three months prior to conception. The polymorphisms of offspring MTHFD1 and MTHFD2 genes at rs2236222, rs11849530, and rs828858 were significantly associated with the risk of CHD. Additionally, a significantly positive interaction between maternal FAS and genetic variation at rs828858 was observed for the risk of CHD. These findings suggested that pregnant women should carefully consider the timing of FAS, and individuals with higher genetic risk may benefit from targeted folic acid supplementation as a preventive measure against CHD. Full article
(This article belongs to the Special Issue Early Life Nutrition and Fetal Health)

Review

Jump to: Research

50 pages, 2635 KiB  
Review
Relationships between the Intakes of Human Milk Components and Body Composition of Breastfed Infants: A Systematic Review
by Isabella Norrish, Azhar Sindi, Vanessa S. Sakalidis, Ching Tat Lai, Jacki L. McEachran, Mya Thway Tint, Sharon L. Perrella, Mark P. Nicol, Zoya Gridneva and Donna T. Geddes
Nutrients 2023, 15(10), 2370; https://doi.org/10.3390/nu15102370 - 18 May 2023
Cited by 6 | Viewed by 2827
Abstract
Human milk provides all of the elements necessary for infant growth and development. Previous studies have reported associations between breastfeeding and a reduced risk of developing obesity and late-onset metabolic disorders; however, the underlying mechanisms are poorly understood. Recently, intakes of human milk [...] Read more.
Human milk provides all of the elements necessary for infant growth and development. Previous studies have reported associations between breastfeeding and a reduced risk of developing obesity and late-onset metabolic disorders; however, the underlying mechanisms are poorly understood. Recently, intakes of human milk components have been associated with infant body composition, which is likely partially implicated in the reduced risk of developing childhood obesity among breastfed infants. In this systematic review, we searched electronic bibliographic databases for studies that explored relationships between the 24 h intakes of human milk macronutrients and bioactive components and infant body composition and/or growth parameters. Of 13 eligible studies, 10 assessed relationships of infant body composition and growth outcomes with human milk macronutrients, while 8 studies assessed relationships with human milk bioactive components. Significant time-dependent relationships with infant anthropometrics and body composition were found for intakes and no relationships for concentrations of several human milk components, such as lactose, total protein, and human milk oligosaccharides, suggesting that measuring concentrations of human milk components without quantifying the intake by the infant may provide a limited understanding. Future studies investigating the effect of human milk components on infant growth and body composition outcomes should consider measuring the actual intake of components and employ standardised methods for measuring milk intake. Full article
(This article belongs to the Special Issue Early Life Nutrition and Fetal Health)
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