Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.0
5.9
Journals
Nutrients
Special Issues
Nutrition and Pediatric Liver Disease
nutrients-logo
Submit to Nutrients Review for Nutrients Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Nutrition and Pediatric Liver Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Pediatric Nutrition".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 5512

Special Issue Editors

Dr. Alok Verma

E-Mail Website
Guest Editor
Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
Interests: fatty liver; metabolic disorders; non-alcoholic fatty liver disease; mitochondrial function
Dr. Akanksha Sharma

E-Mail Website
Guest Editor
Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
Interests: liver inflammation; hepatic stellate cells; hepatic fibrosis

Special Issue Information

Dear Colleague,

The prevalence of pediatric liver disease is increasingly worldwide and representing a major public health concern. Although, several factors are involved in this increase, nutrition is playing   a critical role in liver disease pathogenesis. Obesity and associated complications are major factors in liver diseases in pediatric population while malnutrition during liver disease aggravates the problem.  Lack of awareness delays the liver disease diagnosis in children leads to end-stage liver disease that results in increased morbidity, and mortality. Additionally, childhood liver disorders, such as biliary atresia, autoimmune disorders, HCV, nonalcoholic fatty liver disease (NAFLD), are precursors for future adult liver disease. Children under 18 years old represent 12.5% of all liver transplant patients in the USA. Therefore, prevention will have a major impact on long-term health-care costs. Vitamins deficiency is often associated with liver disease. In addition, Gut-liver axis dysfunction also reported to play role in obesity-related hepatic complications. Recently, nutrient factors implicated in the pathogenesis of intestinal failure–associated liver disease (IFALD) that include non-lipid nutritional components and intravenous lipid emulsions.  Additionally, genetic factors also play an important role in NAFLD as several studies reported that NAFLD can be heritable. Emerging trends of increasing obesity and associated liver diseases can be minimized by alternation in diet composition.

The objective of this proposed Special Issue on “Nutrition and Pediatric Liver Disease” is to publish selected papers (Original research articles, review article, case reports) that will provide the understanding and implication of nutrition in pathogenesis of pediatric liver disease. Also covers the topic of dietary intervention and related therapeutics approach to minimize the risk of liver diseases in pediatric population. In addition, issue will provide the comprehensive understanding and investigation of involved metabolic pathways and nutrition based preventive/therapeutic approaches that can be applied to reduce the hepatic complications in children. Lastly, the knowledge of potential predictive biomarker for liver function/disease at early stage will be helpful to develop therapeutic options for pediatric liver disease.

Dr. Alok Verma
Dr. Akanksha Sharma
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric obesity
  • non-alcoholic fatty liver disease
  • vitamins
  • genetic factors
  • early-life nutrition
  • intestinal failure–associated liver disease (IFALD)
  • biomarker for pediatric liver disease
  • gut-liver axis

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

21 pages, 1775 KiB  
Article
The Role of Vitamin D in Obese Children with Non-Alcoholic Fatty Liver Disease and Associated Metabolic Syndrome
by Mioara Desdemona Stepan, Ștefănița Bianca Vintilescu, Ioana Streață, Mihaela Andreea Podeanu and Dan Nicolae Florescu
Nutrients 2023, 15(9), 2113; https://doi.org/10.3390/nu15092113 - 27 Apr 2023
Cited by 3 | Viewed by 1495
Abstract
Non-alcoholic fatty liver disease (NAFLD) represents a complex chronic condition, which in the absence of screening–monitoring markers and effective standardized treatment is one of the most important issues in pediatric pathology. In this study, we analyzed the role of vitamin D supplementation in [...] Read more.
Non-alcoholic fatty liver disease (NAFLD) represents a complex chronic condition, which in the absence of screening–monitoring markers and effective standardized treatment is one of the most important issues in pediatric pathology. In this study, we analyzed the role of vitamin D supplementation in obese children with/without NAFLD and the impact on the components of the associated metabolic syndrome (MS). The study included 22 children with simple obesity (SO) and 50 with NAFLD, aged between 6 and 14 years, who received regimen-based therapy or vitamin D supplementation in case of deficiency. Anthropometric and paraclinical data associated with MS were statistically compared before and after treatment. It was observed that there was a statistical association of NAFLD with MS components, which were present both in SO and in the 6–9 years group. Vitamin D deficiency was associated with the presence of obesity, NAFLD and MS components, and correction of the deficiency induced a tendency to normalize the associated parameters. In the case of a treatment strictly based on the regimen, we found decreases in vitamin D values and additional alteration of some parameters. Supplementation with vitamin D potentiates the effects of the specific regimen, and the effects seem to be dependent on the MS components. Full article
(This article belongs to the Special Issue Nutrition and Pediatric Liver Disease)
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

19 pages, 655 KiB  
Review
Fat-Soluble Vitamins Deficiency in Pediatric Cholestasis: A Scoping Review
by Irene Degrassi, Ilaria Leonardi, Elisabetta Di Profio, Chiara Montanari, Gianvincenzo Zuccotti and Elvira Verduci
Nutrients 2023, 15(11), 2491; https://doi.org/10.3390/nu15112491 - 26 May 2023
Cited by 1 | Viewed by 1740
Abstract
Background: This review aims to identify the current indications and gaps in the management of fat-soluble vitamins in pediatric patients with cholestasis. Methods: A comprehensive review of the literature using PubMed, Scopus, Web of Science and Embase was performed. Two authors independently identified [...] Read more.
Background: This review aims to identify the current indications and gaps in the management of fat-soluble vitamins in pediatric patients with cholestasis. Methods: A comprehensive review of the literature using PubMed, Scopus, Web of Science and Embase was performed. Two authors independently identified the most relevant studies published over the past 20 years up to February 2022, including original papers, narrative reviews, observational studies, clinical trials, systematic reviews and meta-analyses. The literature was screened, and preclinical studies about pathogenetic mechanisms were also included. Keywords searched for each fat-soluble vitamin (A, D, E and K), alone or in combination, were “cholestasis”, “chronic liver disease”, “biliary atresia”, “malnutrition” and “nutritional needs”. Studies published prior to the selected time range were searched manually and, when considered relevant, included within the list of references. Results: Eight hundred twenty-six articles were initially screened. From these, 48 studies were selected. A comparison of the recommended methods of supplementation for fat-soluble vitamins was then carried out. The causes of malabsorption were explained and current methods for defining deficiency and monitoring complications were summarized. Conclusions: According to the literature, children with cholestasis are at a higher risk of fat-soluble vitamin deficiency. Although there are general recommendations, the treatment for vitamin deficiency is not uniformly validated. Full article
(This article belongs to the Special Issue Nutrition and Pediatric Liver Disease)
►▼ Show Figures

Figure 1

23 pages, 430 KiB  
Review
Nutritional Approaches in Children with Overweight or Obesity and Hepatic Steatosis
by Chiara Spiezia, Claudia Di Rosa, Danilo Fintini, Pietro Ferrara, Laura De Gara and Yeganeh Manon Khazrai
Nutrients 2023, 15(11), 2435; https://doi.org/10.3390/nu15112435 - 23 May 2023
Viewed by 1886
Abstract
Childhood obesity is a global public health problem. Worldwide, 41 million children under 5 years and 340 million children and adolescents between 5 and 19 years are overweight. In addition, the recent COVID-19 epidemic has further amplified this social phenomenon. Obesity is a [...] Read more.
Childhood obesity is a global public health problem. Worldwide, 41 million children under 5 years and 340 million children and adolescents between 5 and 19 years are overweight. In addition, the recent COVID-19 epidemic has further amplified this social phenomenon. Obesity is a condition associated with various comorbidities, such as nonalcoholic fatty liver disease (NAFLD). The pathophysiology of NAFLD in obesity is intricate and involves the interaction and dysregulation of several mechanisms, such as insulin resistance, cytokine signaling, and alteration of the gut microbiota. NAFLD is defined as the presence of hepatic steatosis in more than 5% of hepatocytes, evaluated by histological analysis. It can evolve from hepatic steatosis to steatohepatitis, fibrosis, cirrhosis, hepatocellular carcinoma, and end-stage liver failure. Body weight reduction through lifestyle modification remains the first-line intervention for the management of pediatric NAFLD. Indeed, studies suggest that diets low in fat and sugar and conversely rich in dietary fibers promote the improvement of metabolic parameters. This review aims to evaluate the existing relationship between obesity and NAFLD in the pediatric population and to assess the dietary patterns and nutritional supplementations that can be recommended to prevent and manage obesity and its comorbidities. Full article
(This article belongs to the Special Issue Nutrition and Pediatric Liver Disease)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop