Association between Metabolic Syndrome and the Musculoskeletal System

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 5 May 2024 | Viewed by 3071

Special Issue Editor

Department of Nutrition and Health, China Agricultural University, Beijing, China
Interests: bone; bone diseases and metabolic syndrome; osteoporosis and bone development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In addition to providing the body with structure and movement, the musculoskeletal system also acts as an important endocrine system. Some musculoskeletal disorders, such as osteoporosis and myotonia, are attributed to metabolic dysregulation. On the one hand, the musculoskeletal system produces hormones such as osteocalcin, which affect the metabolic function of other tissue; on the other hand, it has multiple receptors that receive signals from the system’s metabolic changes. The skeletal muscle is the largest insulin-sensitive tissue in the body and is the primary place where insulin stimulates glucose utilization; being overweight causes controversial effects on bone mass and joints, so the disorder of lipid and glucose homeostasis in the metabolism syndrome affects bone and muscle health in many ways. This Special Issue aims to discuss the interaction between metabolic diseases and the musculoskeletal system, including all the hormones and nutritional factors that have changed in this research area, such as carbohydrates, lipids, collagens, insulin, leptin, etc. We welcome the submission of manuscripts reporting original research or reviewing the existing literature on the subject.

Dr. Qian Zhang
Guest Editor

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Keywords

  • musculoskeletal system
  • metabolic disease
  • nutrition

Published Papers (2 papers)

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Editorial

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3 pages, 187 KiB  
Editorial
Association between Metabolic Syndrome and the Musculoskeletal System
by Wenbiao Shi and Qian Zhang
Nutrients 2023, 15(20), 4475; https://doi.org/10.3390/nu15204475 - 22 Oct 2023
Viewed by 1065
Abstract
Metabolic syndrome (MetS) and osteoporosis are chronic health disorders worldwide [...] Full article
(This article belongs to the Special Issue Association between Metabolic Syndrome and the Musculoskeletal System)

Research

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13 pages, 3133 KiB  
Article
Association between Adiposity and Bone Mineral Density in Adults: Insights from a National Survey Analysis
by Yang Jiao, Juan Sun, Yuanmeng Li, Junduo Zhao and Jianxiong Shen
Nutrients 2023, 15(15), 3492; https://doi.org/10.3390/nu15153492 - 07 Aug 2023
Cited by 3 | Viewed by 1506
Abstract
Adiposity and bone mineral density (BMD) are closely associated. The aim of this research was to investigate the association between BMD and adiposity measures in adults, including gynoid percent fat (GPF), android percent fat (APF), total percent fat (TPF), visceral adipose tissue percent [...] Read more.
Adiposity and bone mineral density (BMD) are closely associated. The aim of this research was to investigate the association between BMD and adiposity measures in adults, including gynoid percent fat (GPF), android percent fat (APF), total percent fat (TPF), visceral adipose tissue percent (VAT%), and total lean mass percent (TLM%). Participants (n = 11,615) aged 18 years and older were analyzed using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2018. Associations between BMD and adiposity measures were investigated, and potential differences based on gender and age were explored. Significant negative associations were observed among TPF, APF, GPF, VAT%, and BMD in the fully adjusted models, while TLM% and BMD were positively associated. Stratifying by age and sex, TPF, GPF, and VAT% consistently demonstrated a negative correlation with BMD. In the young adult group, a TPF of 38.2% eliminated the negative correlation between BMD and TPF. Male BMD exhibited an inverted U-shaped relationship with APF, peaking at 35.6%, while a similar pattern was observed for the middle-aged group BMD and APF, with a peak at 31.7%. This large-sample research found a significant negative association between adiposity measures and BMD, providing valuable revelations regarding the intricate connection between adiposity and bone health. Full article
(This article belongs to the Special Issue Association between Metabolic Syndrome and the Musculoskeletal System)
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