Impact of Dietary Bioactives on Muscle Mass, Strength and Performance

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 15 November 2024 | Viewed by 1095

Special Issue Editor


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Guest Editor
Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center (HNRCA), Tufts University, Boston, MA 02111, USA
Interests: gut microbiome; plasma metabolome; aging; soluble fiber; gut–muscle axis; longevity

Special Issue Information

Dear Colleagues,

An emerging role for the gut microbiome in the maintenance of skeletal muscle mass and physical function (defined as the gut–muscle axis) has been identified in young animals, but interventions that positively impact the gut–muscle axis during human aging are sparse.

In this Special Issue, we invite you to publish studies that utilize dietary components to positively impact the gut–muscle axis during human aging. Included amongst the dietary components that may impact the gut–muscle axis are macronutrients, micronutrients, phytonutrients, functional foods, nutritional supplements, and other nutraceuticals. In terms of muscle-related measures that may be impacted by dietary components, skeletal muscle mass, muscle composition, physical function (strength or endurance), sarcopenia, and body composition are of interest. This SI also welcomes manuscripts describing the outcomes of animal studies that have relevance to human health.

Dr. Michael Lustgarten
Guest Editor

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Keywords

  • gut–muscle axis
  • gut–adipose axis
  • fiber
  • phytochemicals
  • body composition
  • physical function
  • muscle mass
  • muscle composition
  • microbiome
  • SCFA

Published Papers (1 paper)

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Research

22 pages, 6870 KiB  
Article
Impact of a Whole-Food, High-Soluble Fiber Diet on the Gut–Muscle Axis in Aged Mice
by Roger A. Fielding and Michael S. Lustgarten
Nutrients 2024, 16(9), 1323; https://doi.org/10.3390/nu16091323 - 28 Apr 2024
Viewed by 797
Abstract
Previous studies have identified a role for the gut microbiome and its metabolic products, short-chain fatty acids (SCFAs), in the maintenance of muscle mass and physical function (i.e., the gut–muscle axis), but interventions aimed at positively impacting the gut–muscle axis during aging are [...] Read more.
Previous studies have identified a role for the gut microbiome and its metabolic products, short-chain fatty acids (SCFAs), in the maintenance of muscle mass and physical function (i.e., the gut–muscle axis), but interventions aimed at positively impacting the gut–muscle axis during aging are sparse. Gut bacteria ferment soluble fiber into SCFAs, and accordingly, to evaluate the impact of a high-soluble-fiber diet (HSFD) on the gut–muscle axis, we fed a whole-food, 3×-higher-soluble fiber-containing diet (relative to standard chow) to aged (98 weeks) C57BL/6J mice for 10 weeks. The HSFD significantly altered gut bacterial community structure and composition, but plasma SCFAs were not different, and a positive impact on muscle-related measures (when normalized to body weight) was not identified. However, when evaluating sex differences between dietary groups, female (but not male) HSFD-fed mice had significant increases for SCFAs, the quadriceps/body weight (BW) ratio, and treadmill work performance (distance run × BW), which suggests that an HSFD can positively impact the gut–muscle axis. In contrast, consistent effects in both male and female HSFD-fed mice included weight and fat loss, which suggests a positive role for an HSFD on the gut–adipose axis in aged mice. Full article
(This article belongs to the Special Issue Impact of Dietary Bioactives on Muscle Mass, Strength and Performance)
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