nutrients-logo

Journal Browser

Journal Browser

Polyphenols and Polyphenol-Rich Foods in Neurodegenerative Disorder

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (20 May 2023) | Viewed by 7338

Special Issue Editors


E-Mail Website
Guest Editor
Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
Interests: flavonoids; polyphenols; polyphenol-rich foods; mental health; nutritional epidemiology; sleep
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Nursing Management and Epidemiology Nursing, Jagiellonian University Medical College, 31-007 Cracow, Poland
Interests: meta-analysis; longitudinal analysis; multi-variable analysis; statistical analysis; epidemiology

Special Issue Information

Dear Colleagues,

The global burden of neurodegenerative disorders is rising, and current research is focusing on the exploration of the basic pathology of neurodegenerative diseases to develop a disease-modifying therapy or cure. Meanwhile, significant attention has been paid to modifiable risk factors, including social, environmental, and dietary risk factors which could possibly be implicated in the prevention of neurodegenerative disorders. Among dietary factors, adherence to traditional plant-based dietary patterns characterized by the high intake of bioactive nutrients such as polyphenols has been shown to exert favorable effects toward brain health. However, evidence regarding the association between individual polyphenol-rich foods, polyphenols, and their metabolites and cognitive health is limited.

Therefore, this Special Issue seeks to increase and summarize evidence on the effects of polyphenols and polyphenol-rich foods on neurodegenerative disorders. Both observational and molecular studies and reviews of published literature, exploring and summarizing the effect of polyphenol-rich foods, individual polyphenols, and their metabolites toward neurodegenerative disorders, as well as related outcomes (such as sleep), will be welcome.

Dr. Justyna Godos
Dr. Agnieszka Micek
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • flavonoids
  • polyphenols
  • polyphenol-rich foods
  • polyphenol-rich beverages
  • nutrition
  • diet
  • cognitive function
  • neurodegenerative diseases
  • Alzheimer’s disease
  • Parkinson’s disease
  • sleep

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

15 pages, 5613 KiB  
Article
Neuroprotective Effects of Ecklonia cava in a Chronic Neuroinflammatory Disease Model
by Seong-Lae Jo, Hyun Yang, Kang-Joo Jeong, Hye-Won Lee and Eui-Ju Hong
Nutrients 2023, 15(8), 2007; https://doi.org/10.3390/nu15082007 - 21 Apr 2023
Cited by 4 | Viewed by 1695
Abstract
Inflammation is a natural defense mechanism against noxious stimuli, but chronic inflammation can lead to various chronic diseases. Neuroinflammation in the central nervous system plays an important role in the development and progression of neurodegenerative diseases. Polyphenol-rich natural products, such as Ecklonia cava [...] Read more.
Inflammation is a natural defense mechanism against noxious stimuli, but chronic inflammation can lead to various chronic diseases. Neuroinflammation in the central nervous system plays an important role in the development and progression of neurodegenerative diseases. Polyphenol-rich natural products, such as Ecklonia cava (E. cava), are known to have anti-inflammatory and antioxidant properties and can provide treatment strategies for neurodegenerative diseases by controlling neuroinflammation. We investigated the effects of an E. cava extract on neuroinflammation and neurodegeneration under chronic inflammatory conditions. Mice were pretreated with E. cava extract for 19 days and then exposed to E. cava with lipopolysaccharide (LPS) for 1 week. We monitored pro-inflammatory cytokines levels in the serum, inflammation-related markers, and neurodegenerative markers using Western blotting and qRT-PCR in the mouse cerebrum and hippocampus. E. cava reduced pro-inflammatory cytokine levels in the blood and brain of mice with LPS-induced chronic inflammation. We also measured the activity of genes related to neuroinflammation and neurodegeneration. Surprisingly, E. cava decreased the activity of markers associated with inflammation (NF-kB and STAT3) and a neurodegenerative disease marker (glial fibrillary acidic protein, beta-amyloid) in the cerebrum and hippocampus of mice. We suggest that E. cava extract has the potential as a protective agent against neuroinflammation and neurodegenerative diseases. Full article
(This article belongs to the Special Issue Polyphenols and Polyphenol-Rich Foods in Neurodegenerative Disorder)
Show Figures

Figure 1

Review

Jump to: Research

16 pages, 689 KiB  
Review
The Interaction of Polyphenols and the Gut Microbiota in Neurodegenerative Diseases
by Yuan Zhang, Wanpeng Yu, Lei Zhang, Man Wang and Wenguang Chang
Nutrients 2022, 14(24), 5373; https://doi.org/10.3390/nu14245373 - 17 Dec 2022
Cited by 16 | Viewed by 4994
Abstract
Polyphenols are secondary metabolites of plants and play a potential role in the prevention and treatment of neurodegenerative diseases (NND) such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) due to their unique physiological functions such as acting as antioxidants, being anti-inflammatory, being [...] Read more.
Polyphenols are secondary metabolites of plants and play a potential role in the prevention and treatment of neurodegenerative diseases (NND) such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) due to their unique physiological functions such as acting as antioxidants, being anti-inflammatory, being neuroprotective, and promoting intestinal health. Since dietary polyphenols exist in plant foods in the form of glycosylation or esterification or are combined with polymers, they need to undergo extensive metabolism through phase I and phase II biotransformations by various intestinal enzymes, as well as metabolism by the intestinal microbiota before they can be fully absorbed. Polyphenols improve intestinal microbiota disorders by influencing the structure and function of intestinal microbiota, inducing beneficial bacteria to produce a variety of metabolites such as short-chain fatty acids (SCFAs), promoting the secretion of hormones and neurotransmitters, and playing an important role in the prevention and treatment of NND by affecting the microbe–gut–brain axis. We review the ways in which some polyphenols can change the composition of the intestinal microbiota and their metabolites in AD or PD animal models to exert the role of slowing down the progression of NND, aiming to provide evidence for the role of polyphenols in slowing the progression of NND via the microbiota–gut–brain (MGB) axis. Full article
(This article belongs to the Special Issue Polyphenols and Polyphenol-Rich Foods in Neurodegenerative Disorder)
Show Figures

Figure 1

Back to TopTop