Caloric Restriction in Metabolism and Aging
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Geriatric Nutrition".
Deadline for manuscript submissions: closed (5 May 2024) | Viewed by 127
Special Issue Editor
Interests: primary cardiovascular prevention; secondary cardiovascular prevention; metabolic syndrome; non-alcoholic fatty liver disease; cardiometabolic risk; coronary artery disease; cardiovascular prevention and epidemiology; arterial hypertension; endothelial function; arterial stiffness; nutrition; diet
Special Issue Information
Dear Colleagues,
Caloric restriction (CR) is a dietary intervention that involves a reduction in the total energy intake without causing malnutrition. Recently, it has gained significant attention in the context of metabolism and aging. Researchers suggest that CR can extend lifespans and improve overall health by influencing various metabolic pathways.
CR impacts metabolism by enhancing cellular stress resistance, increasing mitochondrial function, and reducing oxidative damage. These changes collectively contribute to a healthier metabolic profile by slowing down the rate of age-related disease development, including cardiovascular diseases, type 2 diabetes, and metabolic syndrome.
Furthermore, non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic manifestation of metabolic syndrome; therefore, nutrition and dietary interventions are a cornerstone in its management. To date, dietary CR has been proven to be effective in reducing intrahepatic lipid levels and improving insulin sensitivity among patients with NAFLD. It also lowers inflammation and oxidative stress, both of which play a crucial role in NAFLD progression. Studies in animal models and some human trials have shown promising results, suggesting that CR may be a valuable tool for managing NAFLD and promoting overall longevity. However, further research is needed to fully understand the mechanisms and long-term effects of CR on aging and related metabolic conditions.
This Special Issue of Nutrients welcomes original research articles, cohort studies, case studies, systematic reviews, and meta-analyses that specifically explore the effects of CR regimens in populations with metabolic comorbidities.
Dr. Jolita Badarienė
Guest Editor
Manuscript Submission Information
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Keywords
- caloric restriction
- metabolism
- aging
- metabolic syndrome
- type 2 diabetes
- non-alcoholic fatty liver disease
- nutritional intervention
- cardiometabolic risk
