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Nutritional Interventions in Multiple Sclerosis

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: closed (26 May 2023) | Viewed by 2822

Special Issue Editors


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Guest Editor
Nursing and Physiotherapy Faculty, Universidad de Castilla-La Mancha, Ciudad Real, Spain
Interests: body composition; physical activity; bone health, nutrition
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Health and Social Research Center, Universidad de Castilla-La Mancha, 16002 Cuenca, Spain
Interests: epidemiology and public health; lifestyle; nutrition; sleep disorders and sleep medicine; physical activity; sedentary behavior; mental health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Multiple sclerosis (MS) is a chronic multifactorial, inflammatory and neurodegenerative disease of the central nervous system where genetic susceptibility interacts with environmental factors. Nutrition is one of the environmental factors that may be involved, and plays an essential role in the pathogenesis and evolution of the disease. However, most people with MS do not meet nutritional guidelines for a healthy diet, and usually self-experiment with diet without control of symptoms, medication interaction or adverse effects.

Particular diets or nutrients in the diet can influence the degree of the inflammatory response, suggesting that an appropriate nutritive intervention may improve the risk or prognosis of MS. However, at the present time, there is no strong evidence regarding the efficacy of dietary interventions as a complementary treatment of the disease.

The aim of this Special Issue is elucidate the role of nutrition status, health implications of the diet, nutritional treatment, and/or body composition in relation to MS risk, control, as well as clinical status. 

Dr. Ana Torres-Costoso
Dr. Arthur Eumann Mesas
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multiple sclerosis
  • nutrition
  • nutrients
  • diet
  • malnutrition
  • inflammation
  • body composition

Published Papers (1 paper)

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Review

12 pages, 927 KiB  
Review
Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis
by Purificación López-Muñoz, Ana Isabel Torres-Costoso, Rubén Fernández-Rodríguez, María José Guzmán-Pavón, Sergio Núñez de Arenas-Arroyo, Julián Ángel Basco-López and Sara Reina-Gutiérrez
Nutrients 2023, 15(13), 2861; https://doi.org/10.3390/nu15132861 - 24 Jun 2023
Cited by 3 | Viewed by 2619
Abstract
Vitamin D supplementation has been considered a possible treatment to reduce the risk of disease activity and progression in people with multiple sclerosis (MS). However, its effect on disease symptoms remains unclear. The aim of this meta-analysis was to conduct a systematic review [...] Read more.
Vitamin D supplementation has been considered a possible treatment to reduce the risk of disease activity and progression in people with multiple sclerosis (MS). However, its effect on disease symptoms remains unclear. The aim of this meta-analysis was to conduct a systematic review to assess the effect of vitamin D on fatigue in this population. The systematic review was conducted using the MEDLINE, Cochrane Library, Embase and Web of Science databases from inception to May 2023. Randomized controlled trials (RCTs) reporting pre–post changes in fatigue after vitamin D supplementation were included. Pooled effect sizes and 95% confidence intervals (95% CIs) were calculated by applying a random effects model with Stata/SE (Version 16.0; StataCorp., College Station, TX, USA). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. A total of five studies with 345 individuals (271 females; age range: 25.4–41.1 years) were included. A significant reduction in fatigue was perceived when vitamin D supplementation was compared with a control group: −0.18 (95% CI: −0.36 to −0.01; I2 = 0%). Thus, our findings show that the therapeutic use of vitamin D on fatigue in people with MS could be considered. Nevertheless, due to the lack of agreement on the dose to be applied, it is recommended to use it under medical prescription. Full article
(This article belongs to the Special Issue Nutritional Interventions in Multiple Sclerosis)
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