Effects of Sugars and Sugar Alternatives on Human Health and Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Carbohydrates".

Deadline for manuscript submissions: 15 June 2024 | Viewed by 1347

Special Issue Editors


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Guest Editor
Faculty of Medicine, University of Basel, Basel, Switzerland
Interests: metabolic changes in obesity; links between obesity metabolism and intestinal microbiome; GLP-1 and GI hormones
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Guest Editor
1. St. Clara Research at St. Claraspital Basel, Basel, Switzerland
2. Department of Clinical Research, Faculty of Medicine, University of Basel, Basel, Switzerland
Interests: nutritional physiology and medicine; metabolic changes in obesity; appetite control/regulation of satiety; gastrointestinal hormones; taste perception; gut-brain-axis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

About 30% of the world's population is overweight or obese, which represent an important risk factor for non-communicable diseases, such as cardiovascular disease and metabolic diseases. Several studies report a positive association between the consumption of sugar-sweetened beverages and the worldwide rise in obesity cases. Based on these findings, the World Health Organization recommends a reduction in sugar consumption.

Alternative sweeteners have gained interest as substitutes for conventional sweeteners (such as sucrose, glucose, or fructose). The goal is to achieve a reduction in sugar consumption without compromising the sweet taste. Alternative sweeteners are usually categorized into three groups: artificial low-caloric sweeteners (such as sucralose, aspartame, acesulfame K, etc.), natural low-caloric bulk sweeteners (such as xylitol, erythritol, maltitol, etc.), and rare sugars (such as D-allulose, tagatose, trehalose, etc.).

The role of these alternative sweeteners and their impact on health and disease is, however, highly debated. Although the compounds are approved for human use and considered toxicologically safe, their short- and long-term impacts on human health and disease remains uncertain.

This Special Issue of Nutrition aims to collect the latest research on the links between the effects of sugars and sugar alternatives consumption and human health and disease.

Prof. Dr. Christoph Beglinger
Dr. Anne Christin Meyer-Gerspach
Guest Editors

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Keywords

  • sweeteners
  • low-calorie sweeteners
  • rare sugars
  • cardiovascular disease
  • metabolic disease

Published Papers (1 paper)

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Review

18 pages, 573 KiB  
Review
Metabolic Effects of Selected Conventional and Alternative Sweeteners: A Narrative Review
by Fabienne Teysseire, Valentine Bordier, Christoph Beglinger, Bettina K. Wölnerhanssen and Anne Christin Meyer-Gerspach
Nutrients 2024, 16(5), 622; https://doi.org/10.3390/nu16050622 - 23 Feb 2024
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Abstract
Sugar consumption is known to be associated with a whole range of adverse health effects, including overweight status and type II diabetes mellitus. In 2015, the World Health Organization issued a guideline recommending the reduction of sugar intake. In this context, alternative sweeteners [...] Read more.
Sugar consumption is known to be associated with a whole range of adverse health effects, including overweight status and type II diabetes mellitus. In 2015, the World Health Organization issued a guideline recommending the reduction of sugar intake. In this context, alternative sweeteners have gained interest as sugar substitutes to achieve this goal without loss of the sweet taste. This review aims to provide an overview of the scientific literature and establish a reference tool for selected conventional sweeteners (sucrose, glucose, and fructose) and alternative sweeteners (sucralose, xylitol, erythritol, and D-allulose), specifically focusing on their important metabolic effects. The results show that alternative sweeteners constitute a diverse group, and each substance exhibits one or more metabolic effects. Therefore, no sweetener can be considered to be inert. Additionally, xylitol, erythritol, and D-allulose seem promising as alternative sweeteners due to favorable metabolic outcomes. These alternative sweeteners replicate the benefits of sugars (e.g., sweetness and gastrointestinal hormone release) while circumventing the detrimental effects of these substances on human health. Full article
(This article belongs to the Special Issue Effects of Sugars and Sugar Alternatives on Human Health and Disease)
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