Feature Papers for Nanomanufacturing

A special issue of Nanomanufacturing (ISSN 2673-687X).

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 22058

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Guest Editor
Instituto de Ciencia de Materiales de Madrid (ICMM-CSIC), E-28049 Madrid, Spain
Interests: two-dimensional materials; nanomechanics; strain-engineering; optoelectronics; molybdenum disulfide (MoS2); transition metal dichalcogenides; black phosphorus
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Special Issue Information

Dear colleagues,

This Special Issue is designed to celebrate the founding of the open access journal Nanomanufacturing. The scope of this Special Issue includes but is not limited to: all aspects of lithographic methods aimed at the submicron- to nanoscale; the fabrication and integration of nanostructures, nanomaterials, and surfaces into functional devices; the exploitation and control of self-organization phenomena for patterning; and the further application of the created structures and devices in physical, biomedical, chemistry, environmental science, and life science experiments. We encourage researchers from all areas of nanomanufacturing, nanoengineering and nanotechnology to submit abstracts for this Special Issue.

Nanomanufacturing is an open access journal that normally charges authors a fee. However, MDPI has agreed to publish papers that have been prepared for this founding issue free of any charge.

This will be a dynamic Special Issue, and articles will be published as soon as the reviewers and editors are ready to accept them, without waiting for the deadline for the entire Special Issue to arrive.

Kind regards,

Dr. Andres Castellanos-Gomez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomanufacturing is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (8 papers)

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Research

10 pages, 1521 KiB  
Article
Manufacturing of Carbon Nanotube-Polystyrene Filament for 3D Printing: Nanoparticle Dispersion and Electromagnetic Properties
by Kseniya I. Baskakova, Alexander V. Okotrub, Lyubov G. Bulusheva and Olga V. Sedelnikova
Nanomanufacturing 2022, 2(4), 292-301; https://doi.org/10.3390/nanomanufacturing2040017 - 15 Dec 2022
Cited by 2 | Viewed by 1724
Abstract
3D printing is a promising technology for creating polymer objects of a given architecture with specified functional properties. In fact, the choice of filaments for 3D printing is quite limited. Here, we report a process for producing polystyrene filaments with 0.0025–2 wt.% single-walled [...] Read more.
3D printing is a promising technology for creating polymer objects of a given architecture with specified functional properties. In fact, the choice of filaments for 3D printing is quite limited. Here, we report a process for producing polystyrene filaments with 0.0025–2 wt.% single-walled carbon nanotubes (SWCNTs) by extruding crushed polystyrene composites. The resulting filaments are characterized by a high uniformity of filler distribution and the absence of air pores. Comparison of microscopy data and electromagnetic properties of base composites and composite materials printed from filaments showed that extrusion and printing improve SWCNT dispersion. The proposed method can be used to create filaments for 3D printing of objects from various base polymers containing functional fillers up to the electrical percolation threshold and above. Full article
(This article belongs to the Special Issue Feature Papers for Nanomanufacturing)
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8 pages, 2371 KiB  
Article
Magnesium Sublimation for Growing Thin Films and Conformal Coatings on 1D Nanostructures
by Aaron J. Austin, Nathan P. Dice, Elena Echeverria, Ashish Kumar Gupta, Jonathan Risner, Halle C. Helfrich, Ritesh Sachan and David N. McIlroy
Nanomanufacturing 2022, 2(4), 186-193; https://doi.org/10.3390/nanomanufacturing2040013 - 10 Oct 2022
Cited by 1 | Viewed by 2515
Abstract
A method to conformally coat silica nanosprings with magnesium via sublimation at 450 °C has been developed. In addition, Mg thin films were grown on Si(100) using this method to determine the effects of substrate morphology (nanoscale curvatures vs. planar) on the interfacial [...] Read more.
A method to conformally coat silica nanosprings with magnesium via sublimation at 450 °C has been developed. In addition, Mg thin films were grown on Si(100) using this method to determine the effects of substrate morphology (nanoscale curvatures vs. planar) on the interfacial morphology of the Mg coating. High-resolution/powder X-ray diffraction (HRXRD/PXRD) on both the Mg-coated NS and the thin film revealed the presence of Mgand MgO due to exposure of the samples to air. Scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) confirmed the presence of Mg on the nanosprings. Elemental mapping with TEM-EDS verified that Mg uniformity and conformally coats the nanosprings. Nanocrystallinity of the Mg coating on the nanosprings was determined to be polycrystalline by TEM and selected area electron diffraction (SAED). In contrast, the process produces large micron-scale crystals on planar surfaces. Full article
(This article belongs to the Special Issue Feature Papers for Nanomanufacturing)
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30 pages, 6279 KiB  
Article
Advanced Fabrication of miRNA-Based Electrochemical Nanobiosensor for Diagnosis of Breast Cancer
by Cansu İlke Kuru and Sinan Akgöl
Nanomanufacturing 2022, 2(3), 146-175; https://doi.org/10.3390/nanomanufacturing2030011 - 07 Sep 2022
Cited by 1 | Viewed by 1659
Abstract
Early diagnosis is the key to easy, low cost, and effective treatment of breast cancer. Therefore, studies have been accelerated to identify breast cancer diagnostic biomarkers and diagnose cancer before it progresses. The use of miR-155 as a potential biomarker in breast cancer, [...] Read more.
Early diagnosis is the key to easy, low cost, and effective treatment of breast cancer. Therefore, studies have been accelerated to identify breast cancer diagnostic biomarkers and diagnose cancer before it progresses. The use of miR-155 as a potential biomarker in breast cancer, which has different levels at different stages of the disease, provides a simple serological test for breast cancer prognosis/diagnosis, follow-up, and treatment. Nanopolymers containing different functional groups that are formed by thiol affinity technique were synthesized by mini emulsion polymerization method and advanced characterization studies were carried out in this study to be used as bioactive layers in the nanobiosensor system for miRNA detection. The working conditions of the electrochemical nanobiosensor in which nanopolymers are used as bioactive layers were optimized. Analytical measurement characteristics and validation studies of the nanobiosensor were determined and analysis was performed on commercial blood serum. The potential of the developed electrochemical biosensor to be used as a medical diagnostic kit was explained by comparing it with commercial miRNA kit currently used for the detection of miR-155. This novel nanobiosensor provide sensitive, reliable, and rapid detection of miR-155 and it can provide the potential for breast cancer early diagnosis, prognosis, and follow-up. Full article
(This article belongs to the Special Issue Feature Papers for Nanomanufacturing)
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14 pages, 7481 KiB  
Article
Lipid–Inorganic Hybrid Particles with Non-Lamellar Structures
by Benjamin Schmidbauer, Frank Uhlig and Angela Chemelli
Nanomanufacturing 2022, 2(3), 98-111; https://doi.org/10.3390/nanomanufacturing2030008 - 02 Aug 2022
Viewed by 1723
Abstract
Nanostructured non-lamellar lipid particles are widely studied in various fields of application, although their self-assembled structure is sensitive to internal and external conditions, which may limit their applicability. The aim of this study was to overcome these limitations and create particles with non-lamellar [...] Read more.
Nanostructured non-lamellar lipid particles are widely studied in various fields of application, although their self-assembled structure is sensitive to internal and external conditions, which may limit their applicability. The aim of this study was to overcome these limitations and create particles with non-lamellar nanostructures which are stable over time, upon drying and heating. This was achieved by the combination of two approaches: self-assembly of lipids and polymerization of alkoxysilanes. Precursors containing one or two unsaturated acyl chains were functionalized with trialkoxysilane headgroups. Contrarily to previous studies, the use of unsaturated acyl chains led to the formation of hybrid particles with non-lamellar internal nanostructures. These particles showed a sponge or a hexagonal arrangement and were named spongosomes and hexosomes. Due to the covalent linking of the precursors, durable structures were obtained. The particles were stable for at least several months and maintained their nanostructures even when they were dried or exposed to high temperatures. The inorganic functionalization of lipids enabled the fixation of the self-assembled nanostructures. Full article
(This article belongs to the Special Issue Feature Papers for Nanomanufacturing)
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11 pages, 3527 KiB  
Communication
Nano-Titanium Oxide in Polymeric Contact Lenses: Short Communication
by Lina Mohammed Shaker, Ahmed A. Alamiery, Mohd Takriff and Wan Nor Roslam Wan Isahak
Nanomanufacturing 2022, 2(3), 71-81; https://doi.org/10.3390/nanomanufacturing2030006 - 30 Jun 2022
Cited by 10 | Viewed by 2915
Abstract
Many individuals suffer from myopia or hyperopia and astigmatism owing to the refractive defects of the eye optics or because of the use of inappropriate contact lenses. This study dealt with three polymers Poly(methyl methacrylate) (PMMA), Poly(Hydroxyl methacrylate) (PHEMA), and Poly(glycidyl methacrylate) (PGMA) [...] Read more.
Many individuals suffer from myopia or hyperopia and astigmatism owing to the refractive defects of the eye optics or because of the use of inappropriate contact lenses. This study dealt with three polymers Poly(methyl methacrylate) (PMMA), Poly(Hydroxyl methacrylate) (PHEMA), and Poly(glycidyl methacrylate) (PGMA) and doping them with TiO2 nanoparticles to evaluate the difference between the effect of each lens on the human eye. The TiO2 NPs were prepared in this work by the sol–gel method to obtain 70–90 nm sized particles. Modulation transfer (MTF) and spot diagram were assessed to measure ocular performance. The PGMA-TiO2 contact lens provided the highest image quality at the lowest probability (P) of about p < 0.0001 when inserted on an aberrated eye system because of its ability to eliminate the chromatic aberrations created inside the eyes having a smaller spot size. Full article
(This article belongs to the Special Issue Feature Papers for Nanomanufacturing)
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12 pages, 1942 KiB  
Article
Lipid-Based Formulations Containing Labrafil M2125-CS: A Deep Investigation on Nanosystem Stability
by Martine Tarsitano, Maria Chiara Cristiano, Antonia Mancuso, Antonella Barone, Daniele Torella and Donatella Paolino
Nanomanufacturing 2022, 2(1), 41-52; https://doi.org/10.3390/nanomanufacturing2010003 - 15 Feb 2022
Cited by 5 | Viewed by 3082
Abstract
Labrafil M2125-CS is a non-ionic surfactant component widely used for improving the solubilization of poor water-soluble drugs and as component of lipid-based nanosystem formulation. The aim of this research work was to evaluate in depth the stability of lipid-based nanosystems when exposed at [...] Read more.
Labrafil M2125-CS is a non-ionic surfactant component widely used for improving the solubilization of poor water-soluble drugs and as component of lipid-based nanosystem formulation. The aim of this research work was to evaluate in depth the stability of lipid-based nanosystems when exposed at several experimental conditions, such as temperature- and pH-variations, and during a specific storage process—lyophilization. Dynamic light scattering was the main analysis carried out during this research work for investigating eventual physico-chemical variations of nanosystem properties after different storage phases. We demonstrated that many of prepared formulations were able to maintain almost unchanged mean size and polydispersity index values, resisting acid and basic pH or high and low temperature, as well as the freeze-drying process. Finally, the results showed that there are no univocal experimental conditions suitable for the storage of all formulation types, but each sample requires customized conditions. Full article
(This article belongs to the Special Issue Feature Papers for Nanomanufacturing)
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11 pages, 689 KiB  
Communication
Influence of the Physico-Chemical Properties of Model Compounds on the Mean Sizes and Retention Rate of Gliadin Nanoparticles
by Silvia Voci, Massimo Fresta and Donato Cosco
Nanomanufacturing 2021, 1(3), 160-170; https://doi.org/10.3390/nanomanufacturing1030011 - 19 Nov 2021
Cited by 2 | Viewed by 2438
Abstract
Vegetal proteins have emerged as appealing starting materials for the development of various drug delivery systems, and their use for obtaining polymeric nanoparticles has been profitably exploited in multidisciplinary fields. Wheat gliadin, the water-insoluble storage protein of gluten, is characterized by a great [...] Read more.
Vegetal proteins have emerged as appealing starting materials for the development of various drug delivery systems, and their use for obtaining polymeric nanoparticles has been profitably exploited in multidisciplinary fields. Wheat gliadin, the water-insoluble storage protein of gluten, is characterized by a great amount of hydrophobic amino acid residues and notable mucoadhesive features. This biopolymer can be easily manipulated to form colloidal carriers, films and fibers by means of bio-acceptable solvents and easy preparation procedures. In this investigation, four model compounds characterized by different octanol/water partition coefficient (logP) values were encapsulated in gliadin nanoparticles, with the aim of investigating the influence of their physico-chemical properties on the cargo features and technological characteristics of the protein nanocarriers. The results demonstrate that the chemical structure, solubility and molecular weight of the compounds used are able to dramatically modulate the mean sizes and the entrapment efficiency of gliadin nanoparticles. This demonstrates the importance of a preformulation investigation when a molecule needs to be encapsulated in this type of polymeric carrier. Full article
(This article belongs to the Special Issue Feature Papers for Nanomanufacturing)
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25 pages, 2289 KiB  
Article
A New Nanomaterial Based Biosensor for MUC1 Biomarker Detection in Early Diagnosis, Tumor Progression and Treatment of Cancer
by Fulden Ulucan-Karnak and Sinan Akgöl
Nanomanufacturing 2021, 1(1), 14-38; https://doi.org/10.3390/nanomanufacturing1010003 - 13 May 2021
Cited by 3 | Viewed by 4335
Abstract
Early detection of cancer disease is vital to the successful treatment, follow-up and survival of patients, therefore sensitive and specific methods are still required. Mucin 1 (MUC1) is a clinically approved biomarker for determining the cancer that is a type I transmembrane protein [...] Read more.
Early detection of cancer disease is vital to the successful treatment, follow-up and survival of patients, therefore sensitive and specific methods are still required. Mucin 1 (MUC1) is a clinically approved biomarker for determining the cancer that is a type I transmembrane protein with a dense glycosylated extracellular domain extending from the cell surface to 200–500 nm. In this study, nanopolymers were designed with a lectin affinity-based recognition system for MUC1 detection as a bioactive layer on electrochemical biosensor electrode surfaces. They were synthesized using a mini emulsion polymerization method and derivatized with triethoxy-3-(2-imidazolin-1-yl) propylsilane (IMEO) and functionalized with Concanavalin a Type IV (Con A) lectin. Advanced characterization studies of nanopolymers were performed. The operating conditions of the sensor system have been optimized. Biosensor validation studies were performed. Real sample blood serum was analyzed and this new method compared with a commercially available medical diagnostic kit (Enzyme-Linked ImmunoSorbent Assay-ELISA). The new generation nanopolymeric material has been shown to be an affordable, sensitive, reliable and rapid device with 0.1–100 U/mL linear range and 20 min response time. Full article
(This article belongs to the Special Issue Feature Papers for Nanomanufacturing)
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