Pathogenesis and Immunology of Cytomegalovirus
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: closed (25 February 2024) | Viewed by 925
Special Issue Editor
2. Department of Laboratory Medicine and Anatomical Pathology, University Hospital of Modena—Polyclinic, Modena, Italy
Interests: pathology oncology gynecology; human papilloma virus (HPV); epstein–barr virus (EBV); human herpes virus 8 (HHV8); coronavirus disease 2019 (COVID-19); severe acute respiratory syndrome (SARS); middle east respiratory syndrome (MERS); nipah virus ebola virus
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cytomegalovirus (CMV), alias human herpes virus 5 (HHV5), is a double-stranded deoxyribonucleic acid (DNA) virus contagious to humans via saliva, urine, blood, and breast milk. First observed by the German pathologist Hugo Ribbert in 1881, when he noticed, under the microscope, mega-cells with enlarged nuclei containing a so called owl's eye inclusion in an affected infant, the American virologist Thomas Huckle Weller isolated the virus between 1956 and 1957. In 1990, the first draft of the human CMV genome was published, the biggest contiguous genome sequenced at that time. Today, CMV is still the virus most frequently transmitted to a developing fetus, and congenital CMV, the leading infectious cause of deafness, learning disabilities, and intellectual disability in children, can even be deadly. In fact, CMV infection is typically silent in healthy subjects, but it can become life-threatening for the immunocompromised, such as newborn infants, acquired immunodeficiency syndrome (AIDS) patients, organ transplant recipients, and persons in chemotherapy. After infection, CMV remains latent throughout life and can be reactivated at any circumstance of immunosuppression, causing pneumonia, hepatitis, colitis, esophagitis, encephalitis, retinitis, infectious mononucleosis-like syndrome, or CMV polyradiculomyelopathy (PRAM). Some authors have also advanced molecular roles in inflammaging, immunosenescence, atherosclerosis, and oncogenesis, for example, in mucoepidermoid carcinoma of the salivary glands. The aim of this Special Issue is, therefore, a full immersion in the pathogenesis and immunology of CMV.
Prof. Dr. Luca Roncati
Guest Editor
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Keywords
- cytomegalovirus (CMV)
- human herpes virus 5 (HHV5)
- congenital CMV
- fetus
- acquired immunodeficiency syndrome (AIDS)
- CMV polyradiculomyelopathy (PRAM)
- inflammaging
- immunosenescence
- pathogenesis
- immunology
