Journal Browser

Journal Browser

Special Issue "Pathogenesis and Immunology of Cytomegalovirus"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 25 February 2024 | Viewed by 111

Special Issue Editor

1. Department of Laboratory Medicine and Anatomical Pathology, Institute of Pathology, University Hospital of Modena-Polyclinic, 41124 Modena, Italy
2. Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplantation, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, 41121 Modena, Italy
Interests: anatomical pathology; surgical anatomy; histopathology; lymphatics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cytomegalovirus (CMV), alias human herpes virus 5 (HHV5), is a double-stranded deoxyribonucleic acid (DNA) virus contagious to humans via saliva, urine, blood, and breast milk. First observed by the German pathologist Hugo Ribbert in 1881, when he noticed, under the microscope, mega-cells with enlarged nuclei containing a so called owl's eye inclusion in an affected infant, the American virologist Thomas Huckle Weller isolated the virus between 1956 and 1957. In 1990, the first draft of the human CMV genome was published, the biggest contiguous genome sequenced at that time. Today, CMV is still the virus most frequently transmitted to a developing fetus, and congenital CMV, the leading infectious cause of deafness, learning disabilities, and intellectual disability in children, can even be deadly. In fact, CMV infection is typically silent in healthy subjects, but it can become life-threatening for the immunocompromised, such as newborn infants, acquired immunodeficiency syndrome (AIDS) patients, organ transplant recipients, and persons in chemotherapy. After infection, CMV remains latent throughout life and can be reactivated at any circumstance of immunosuppression, causing pneumonia, hepatitis, colitis, esophagitis, encephalitis, retinitis, infectious mononucleosis-like syndrome, or CMV polyradiculomyelopathy (PRAM). Some authors have also advanced molecular roles in inflammaging, immunosenescence, atherosclerosis, and oncogenesis, for example, in mucoepidermoid carcinoma of the salivary glands. The aim of this Special Issue is, therefore, a full immersion in the pathogenesis and immunology of CMV.

Prof. Dr. Luca Roncati
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cytomegalovirus (CMV)
  • human herpes virus 5 (HHV5)
  • congenital CMV
  • fetus
  • acquired immunodeficiency syndrome (AIDS)
  • CMV polyradiculomyelopathy (PRAM)
  • inflammaging
  • immunosenescence
  • pathogenesis
  • immunology

Published Papers

This special issue is now open for submission.
Back to TopTop