Editorial Board Members’ Collection Series: “Bacterial Enzymes as Targets”
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 1072
Special Issue Editors
Interests: protein biochemistry; recombinant protein; heterologous expression; carbonic anhydrase; enzyme and protein purification; enzyme characterization; enzyme thermostability; cold-adapted enzymes
Special Issues, Collections and Topics in MDPI journals
Interests: biology of bacteriophages; biodiversity of bacteriophages; regulation of bacteriophage development; regulation of phage gene expression; control of phage DNA replication; phage therapy; phages bearing genes of toxins; bacteriophage genomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Exploring the enzymes essential for key bacterial functions presents an opportunity to develop innovative strategies for combating bacterial infections. Enzymes involved in cell wall biosynthesis are critical for maintaining bacterial cell structure and integrity. By inhibiting these enzymes, it is possible to disrupt cell wall formation, rendering bacteria susceptible to immune responses or other treatments. Similarly, enzymes involved in DNA replication are essential for bacterial proliferation. Targeting these enzymes can impede DNA synthesis and disrupt bacterial replication, potentially curbing infection progression. Bacteria often harbor metabolic pathways distinct from those of human cells, presenting opportunities that allow bacterial enzymes to be selectively targeted without affecting host cells. Moreover, by focusing on enzymes pivotal for bacterial survival, such as carbonic anhydrase, novel therapeutic strategies can be designed to offer effective treatment options for bacterial infections. Thus, the process of understanding and targeting specific bacterial enzymes represents a promising avenue for the development of novel antibacterial agents, as well as for tackling infections and combating antibiotic resistance.
Prof. Dr. Clemente Capasso
Prof. Dr. Alicja Wegrzyn
Guest Editors
Manuscript Submission Information
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Keywords
- enzymes
- cell wall biosynthesis
- DNA replication
- metabolic pathway
- vital bacterial function
- enzyme inhibition
- antibacterial agents
- antibiotic resistance
