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Special Issue "Editorial Board Members’ Collection Series: "Enzyme Inhibition""

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 March 2024 | Viewed by 95

Special Issue Editors

Neurofarba Department, Section of Farmaceutical and Neutraceutical Sciences, University of Florence, Sesto Fiorentino, 50019 Florence, Italy
Interests: drug design; metalloenzymes; carbonic anhydrases; anticancer agents; antiinfectives; sulfonamides; coumarins
Special Issues, Collections and Topics in MDPI journals
1. International Centre for Research on Innovative Biobased Materials (ICRI-BioM)—International Research Agenda, Lodz University of Technology, Lodz, Poland
2. Faculty of Chemistry, Institute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, Poland
Interests: isotope effects; mechanism of chemical and enzymatic reactions; enzyme inhibition; isotopic fractionation; isotope-ratio mass spectrometry; computational chemistry; docking
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The human genome only encodes for around 30,000 genes, which is one third of what was previously believed before the first genomes were cloned, and there has been still significant debate surrounding how many of them are druggable. Presently clinically used drugs act on around 400 of these targets pertaining to proteins, nucleic acids, and (more rarely) sugars or lipids, which belong to the human host or various pathogens (bacteria, fungi, protozoans, and other parasites). Around 50% of the known drug targets are enzymes; thus, enzyme inhibition (and, in some cases, activation) constitutes an important field of biomedical research and therapeutic intervention. The present Special Issue will address all research topics connected with enzymes, as well as their inhibition and activation, based on molecular biology, structural chemical biology, drug design, and pharmacological studies in the field. All enzyme classes will be considered as relevant proteins for such research topics, albeit with a preference for those connected to major biomedical problems, i.e., cancer, infectious diseases, drug resistance, obesity, as well as cardiovascular and central nervous system conditions.

Prof. Dr. Claudiu T. Supuran
Prof. Dr. Piotr Paneth
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • enzyme inhibition
  • enzyme activators
  • magnesium/calcium-containing enzymes
  • zinc/iron enzymes
  • cancer
  • drug resistance
  • antiinfectives

Published Papers

This special issue is now open for submission.
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