Special Issue "Carbonic Anhydrase and Carbonic Anhydrase Inhibitors 2.0"
Deadline for manuscript submissions: 31 December 2023 | Viewed by 217
Interests: drug design; metalloenzymes; carbonic anhydrases; anticancer agents; antiinfectives; sulfonamides; coumarins
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The metalloenzyme carbonic anhydrase (CA) is expressed in organisms all over the phylogenetic tree of life, with eight genetic families known to date. By equilibrating CO2 and bicarbonate with the generation of protons, CAs play a crucial role in pH regulation, electrolyte secretion, metabolism (lipogenesis, gluconeogenesis, ureagenesis). CA inhibitors are clinically used as diuretics, antiglaucoma agents, and antiepileptics, but novel applications in the management of cancer, neuropathic pain, sleep apnea, migraine, intracranial pressure lowering, and cerebral ischemia are being investigated. CA activators are involved in memory and fear extinction, and are thus useful in the treatment of cognitive impairment and phobias. This topical collection provides an update in these fields, with reviews/original articles dedicated to the various applications of inhibitors/activators in therapy as well as biomedical applications of prokaryotic CAs, with CAs widely abundant in pathogenic bacteria in addition to fungi, protozoa, and other pathogens. The modulators of activity of these enzymes offer useful applications in a variety of biomedical and biotechnological fields.
Prof. Dr. Claudiu T. Supuran
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- carbonic anhydrase
- antitumor agent
- Alzheimer’s disease