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Special Issue "Carbonic Anhydrase and Carbonic Anhydrase Inhibitors 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 217

Special Issue Editor

Neurofarba Department, Section of Farmaceutical and Neutraceutical Sciences, University of Florence, Sesto Fiorentino, 50019 Florence, Italy
Interests: drug design; metalloenzymes; carbonic anhydrases; anticancer agents; antiinfectives; sulfonamides; coumarins
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The metalloenzyme carbonic anhydrase (CA) is expressed in organisms all over the phylogenetic tree of life, with eight genetic families known to date. By equilibrating CO2 and bicarbonate with the generation of protons, CAs play a crucial role in pH regulation, electrolyte secretion, metabolism (lipogenesis, gluconeogenesis, ureagenesis). CA inhibitors are clinically used as diuretics, antiglaucoma agents, and antiepileptics, but novel applications in the management of cancer, neuropathic pain, sleep apnea, migraine, intracranial pressure lowering, and cerebral ischemia are being investigated. CA activators are involved in memory and fear extinction, and are thus useful in the treatment of cognitive impairment and phobias. This topical collection provides an update in these fields, with reviews/original articles dedicated to the various applications of inhibitors/activators in therapy as well as biomedical applications of prokaryotic CAs, with CAs widely abundant in pathogenic bacteria in addition to fungi, protozoa, and other pathogens. The modulators of activity of these enzymes offer useful applications in a variety of biomedical and biotechnological fields.

Prof. Dr. Claudiu T. Supuran
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • carbonic anhydrase
  • inhibitor
  • activator
  • antitumor agent
  • anti-infectives
  • diuretics
  • antiepileptics
  • Alzheimer’s disease

Published Papers

This special issue is now open for submission.
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