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Carbonic Anhydrase and Carbonic Anhydrase Inhibitors 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 15 May 2024 | Viewed by 561

Special Issue Editor

Neurofarba Department, Section of Farmaceutical and Neutraceutical Sciences, University of Florence, Sesto Fiorentino, 50019 Florence, Italy
Interests: drug design; metalloenzymes; carbonic anhydrases; anticancer agents; antiinfectives; sulfonamides; coumarins
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The metalloenzyme carbonic anhydrase (CA) is expressed in organisms all over the phylogenetic tree of life, with eight genetic families known to date. By equilibrating CO2 and bicarbonate with the generation of protons, CAs play a crucial role in pH regulation, electrolyte secretion, metabolism (lipogenesis, gluconeogenesis, ureagenesis). CA inhibitors are clinically used as diuretics, antiglaucoma agents, and antiepileptics, but novel applications in the management of cancer, neuropathic pain, sleep apnea, migraine, intracranial pressure lowering, and cerebral ischemia are being investigated. CA activators are involved in memory and fear extinction, and are thus useful in the treatment of cognitive impairment and phobias. This topical collection provides an update in these fields, with reviews/original articles dedicated to the various applications of inhibitors/activators in therapy as well as biomedical applications of prokaryotic CAs, with CAs widely abundant in pathogenic bacteria in addition to fungi, protozoa, and other pathogens. The modulators of activity of these enzymes offer useful applications in a variety of biomedical and biotechnological fields.

Prof. Dr. Claudiu T. Supuran
Guest Editor

Manuscript Submission Information

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Keywords

  • carbonic anhydrase
  • inhibitor
  • activator
  • antitumor agent
  • anti-infectives
  • diuretics
  • antiepileptics
  • Alzheimer’s disease

Published Papers

This special issue is now open for submission.
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