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Transcriptomic and Proteomic Changes Due to Mycotoxins Exposure from Foods
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Transcriptomic and Proteomic Changes Due to Mycotoxins Exposure from Foods

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Toxicology".

Deadline for manuscript submissions: closed (28 February 2024) | Viewed by 2252

Special Issue Editor

Prof. Dr. Lara Manyes

E-Mail Website
Guest Editor
Department of Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine, University of Valencia, Burjassot, Spain
Interests: omics; mycotoxins; toxicology in vitro; toxicology in vivo; food safety; risk assessment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Given the depth of your expertise in this field, I would like to cordially invite you to contribute an article to the Special Issue. Mycotoxins are already one of the main food and feed contaminants and climate change is anticipated to impact on their presence. In order to provide the society with sufficient information about their toxicity, we scientists need to investigate not only the visible toxicity symptoms, but also the mechanisms of action that these mycotoxins trigger. As you know, omics involve collective technologies and approaches to explore the roles of various molecules which constitute cells within living organisms. In recent years, omics have extended from the initial genomics to a wide range of biomolecular disciplines aimed to study specific characteristics considered as a whole. The interpretation of omics data can provide valuable information on the functional status of an organism and on the effect of external factors such as mycotoxins. This Special Issue aims for a better understanding of mycotoxins mechanisms of action and toxicity effects through a transcriptomic and proteomics approach by using in vitro, ex vivo and in vivo models.

Prof. Dr. Lara Manyes
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mycotoxin
  • transcriptomics
  • next-generation sequencing
  • proteomics
  • in vitro
  • in vivo
  • ex vivo
  • risk assessment
  • mechanism of action

Published Papers (1 paper)

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Research

17 pages, 2223 KiB  
Article
AFB1 and OTA Promote Immune Toxicity in Human LymphoBlastic T Cells at Transcriptomic Level
by Massimo Frangiamone, Manuel Lozano, Alessandra Cimbalo, Guillermina Font and Lara Manyes
Foods 2023, 12(2), 259; https://doi.org/10.3390/foods12020259 - 06 Jan 2023
Cited by 6 | Viewed by 1962
Abstract
Aflatoxin B1 (AFB1) and ochratoxin A (OTA) are typical contaminants of food and feed, which have serious implications for human and animal health, even at low concentrations. Therefore, a transcriptomic study was carried out to analyze gene expression changes triggered by low doses [...] Read more.
Aflatoxin B1 (AFB1) and ochratoxin A (OTA) are typical contaminants of food and feed, which have serious implications for human and animal health, even at low concentrations. Therefore, a transcriptomic study was carried out to analyze gene expression changes triggered by low doses of AFB1 and OTA (100 nM; 7 days), individually and combined, in human lymphoblastic T cells. RNA-sequencing analysis showed that AFB1-exposure resulted in 99 differential gene expressions (DEGs), while 77 DEGs were obtained in OTA-exposure and 3236 DEGs in the combined one. Overall, 16% of human genome expression was altered. Gene ontology analysis revealed, for all studied conditions, biological processes and molecular functions typically associated with the immune system. PathVisio analysis pointed to ataxia telangiectasia mutated signaling as the most significantly altered pathway in AFB1-exposure, glycolysis in OTA-exposure, and ferroptosis in the mixed condition (Z-score > 1.96; adjusted p-value ≤ 0.05). Thus, the results demonstrated the potential DNA damage caused by AFB1, the possible metabolic reprogramming promoted by OTA, and the plausible cell death with oxidative stress prompted by the mixed exposure. They may be considered viable mechanisms of action to promote immune toxicity in vitro. Full article
(This article belongs to the Special Issue Transcriptomic and Proteomic Changes Due to Mycotoxins Exposure from Foods)
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