Special Issue "Bioactive Compounds in the Spotlight: State-of-the-Art Research in Dietary Supplements, Functional Foods, and Nutraceuticals"

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Nutraceuticals, Functional Foods, and Novel Foods".

Deadline for manuscript submissions: 5 February 2024 | Viewed by 749

Special Issue Editors

Alianza Latinoamericana De Nutrición Responsable (ALANUR), Inc., 400 E. Randolph St. Suite 2305, Chicago, IL 60611, USA
Interests: bioactive compounds; food waste valorization; encapsulation and emulsion technologies; antioxidant, anti-inflammatory, and antiproliferative properties of bioactive compounds; functional foods and nutraceuticals; dietary supplements; consumer habits and dietary products; sustainability in food production and processing
CONACYT-Centro de Investigación en Alimentación y Desarrollo A. C, Carretera Gustavo Enrique Astiazarán Rosas, No. 46, Col. La Victoria, Hermosillo 83304, Mexico
Interests: agri-food science and technology; antioxidants; bioactive compounds; phenolic compounds; gut-brain axis; metabolism

Special Issue Information

Dear Colleagues,

For decades, scientific literature has robustly substantiated the health benefits of bioactive compounds, showing impacts far beyond basic nutritional properties. Antioxidant, anti-inflammatory, and antimicrobial activities are just a few of the beneficial attributes that bioactive compounds obtained from natural sources have demonstrated. The advent of new technologies will allow us to harness these compounds as ingredients in dietary supplements, functional foods, and nutraceuticals. However, the challenge lies in ensuring and enhancing their safety, stability, bioavailability, and sensory properties in the final product.

This Special Issue aims to present the state-of-the-art knowledge and developments in this field, striving to contribute to the scientific community's progress in formulating such foods. This initiative aligns with emerging trends in sustainability throughout the world, acknowledging the increased demand for healthful, easy-to-prepare foods with minimized environmental impact.

We cordially invite contributions that explore this fascinating crossroad of food science, nutrition, health, and technology. Let us collectively illuminate the prospects of bioactive compounds in shaping the future of dietary supplements, functional foods, and nutraceuticals.

Dr. Gustavo R. Velderrain-Rodríguez
Dr. J. Abraham Domínguez-Avila
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • bioactive peptides
  • polyphenols
  • probiotics
  • phytochemicals
  • algae-derived nutraceuticals
  • plant-based meat
  • functional dairy products
  • natural food additives
  • functional beverages
  • healthy fats

Published Papers (1 paper)

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20 pages, 2148 KiB  
Dietary Phenolic Compounds Exert Some of Their Health-Promoting Bioactivities by Targeting Liver X Receptor (LXR) and Retinoid X Receptor (RXR)
Foods 2023, 12(23), 4205; https://doi.org/10.3390/foods12234205 - 22 Nov 2023
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Consuming foods of vegetable origin has been shown to exert multiple health-related effects, many of them attributed to their phenolic compounds. These molecules are known for being bioactive across multiple cells and organs, with documented changes in gene expression being commonly reported. Nuclear [...] Read more.
Consuming foods of vegetable origin has been shown to exert multiple health-related effects, many of them attributed to their phenolic compounds. These molecules are known for being bioactive across multiple cells and organs, with documented changes in gene expression being commonly reported. Nuclear receptors are signal transducers capable of regulating gene expression in response to endogenous and/or exogenous ligands. Liver X receptor (LXR) and retinoid X receptor (RXR) are two important nuclear receptors that can be acted on by phenolic compounds, thereby modifying gene expression and potentially exerting numerous subsequent bioactivities. The present work summarizes recent evidence of the effects of the phenolic compounds that are exerted by targeting LXR and/or RXR. The data show that, when LXR is being targeted, changes in lipid metabolism are commonly observed, due to its ability to regulate genes relevant to this process. The effects vary widely when RXR is the target since it is involved in processes like cell proliferation, vitamin D metabolism, and multiple others by forming heterodimers with other transcription factors that regulate said processes. The evidence therefore shows that phenolic compounds can exert multiple bioactivities, with a mechanism of action based, at least in part, on their ability to modulate the cell at the molecular level by acting on nuclear receptors. The data point to a promising and novel area of study that links diet and health, although various unknowns justify further experimentation to reveal the precise way in which a given phenolic can interact with a nuclear receptor. Full article
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