Oral-Systemic Health and Disorders: Latest Advances and Prospects

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 7438

Special Issue Editors


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Guest Editor
Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania L. Vanvitelli, Naples, Italy
Interests: oral microbiome; oral microbiota; disbiosis; oral pathology and medicine; pediatric dentistry; dentistry; oral cancer; oral infections; oral mycology
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Special Issue Information

Dear Colleagues,

Multiple pieces of evidence have long supported the existence of several multi-level interconnections between oral and general health status, being affected by genetic, neurobiological, nutritional, and metabolic factors, as well as by microbiome balance and immune-inflammatory reactivity. Therefore, a better comprehension of the etiopathogenic links between oral, dental, and periodontal conditions, on the one side, and systemic degenerative, inflammatory, and neoplastic disorders, along with systemically administered medications, on the other side, may pave the way for patient-centered preventive and therapeutic strategies, with personalized approaches.

Original studies, investigating interconnections between oral and general health and providing highlights on the putative mechanisms underlying such inter-relations, as well as reviews, perspectives, and communications, focused on a comprehensive and integrated management of oral and general health, are welcomed.

Dr. Federica Di Spirito
Dr. Maria Contaldo
Dr. Alessandra Amato
Guest Editors

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Keywords

  • general health
  • oral health
  • dental health
  • periodontal health
  • peri-implant health
  • stomatomucositis
  • comorbidities
  • drugs
  • oral cancer
  • oral lesions
  • oral microbiome
  • oral dysbiosis
  • periodontal disease
  • gingivitis
  • periodontitis
  • peri-implant disease
  • peri-implant mucositis
  • peri-implantitis
  • oral care
  • periodontal care
  • dental care
  • oral manifestations of systemic disease
  • periodontal manifestations of systemic disease
  • oral adverse drug reaction
  • interdisciplinary approach

Published Papers (4 papers)

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Editorial

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3 pages, 199 KiB  
Editorial
Oral-Systemic Health and Disorders: Latest Advances on Oral–Gut–Lung Microbiome Axis
by Alessandra Amato
Appl. Sci. 2022, 12(16), 8213; https://doi.org/10.3390/app12168213 - 17 Aug 2022
Cited by 15 | Viewed by 2072
Abstract
The human body hosts complex microbial communities, accounting for 100 trillion microbial symbionts, much more than human cells, aiding nutrition, counteracting pathogens, and collaborating with our immune system [...] Full article
(This article belongs to the Special Issue Oral-Systemic Health and Disorders: Latest Advances and Prospects)
3 pages, 200 KiB  
Editorial
Oral-Systemic Health and Disorders: Latest Prospects on Oral Antisepsis
by Federica Di Spirito
Appl. Sci. 2022, 12(16), 8185; https://doi.org/10.3390/app12168185 - 16 Aug 2022
Cited by 24 | Viewed by 1112
Abstract
A growing body of evidence supports the inter-connections between oral dysbiosis [...] Full article
(This article belongs to the Special Issue Oral-Systemic Health and Disorders: Latest Advances and Prospects)

Research

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11 pages, 1570 KiB  
Article
Evaluation and Comparison of Cortisol Levels in Saliva and Hair among Dental Students
by Mohammed A. AlSarhan, Reham N. AlJasser, Saleh AlOraini, Syed Rashid Habib, Rawan Ahmad Alayoub, Lulwah Tawfiq Almutib, Haya Dokhi Aldokhi and Heyam Humood AlKhalaf
Appl. Sci. 2023, 13(2), 678; https://doi.org/10.3390/app13020678 - 04 Jan 2023
Cited by 2 | Viewed by 1881
Abstract
Cortisol has frequently been used as a stress marker, and the variation in cortisol levels in saliva and hair, as well as between males and females, has been reported. This study aimed to evaluate and compare the level of cortisol variation in hair [...] Read more.
Cortisol has frequently been used as a stress marker, and the variation in cortisol levels in saliva and hair, as well as between males and females, has been reported. This study aimed to evaluate and compare the level of cortisol variation in hair and saliva among dental students of both genders. After giving written agreement, 151 students (79 males and 72 females) participated in the study. Saliva and hair samples were collected at two time intervals with a gap of three months from the same set of participants. Saliva and hair samples were utilized to measure the levels of cortisol using an enzyme-linked immunosorbent assay (ELISA). Each participant’s salivary and hair cortisol levels and demographic information, including age and gender, were recorded. To examine group comparisons, two-tailed Student’s t-tests were used (α < 0.05). The comparisons of salivary and hair cortisol levels showed significant difference (p < 0.05) at two time intervals. Genderwise comparisons of the salivary and hair cortisol’s levels showed significant differences (p < 0.05) for male students, while, for female students, the comparisons showed non-significant differences (p > 0.05). Comparisons between the cortisol levels of the two specimen collections at the two different time intervals indicated substantial variations (p = 0.000). Results confirm the variations in the cortisol levels in the saliva and hair samples. Cortisol concentrations in hair and saliva at the two times points varied. Significant variations between the male students salivary and hair cortisol levels and non-significant differences between the cortisol levels for the female students at the two time points were found. Cortisol levels in the selected subjects’ saliva and hair samples varied. Full article
(This article belongs to the Special Issue Oral-Systemic Health and Disorders: Latest Advances and Prospects)
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Other

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28 pages, 1908 KiB  
Systematic Review
Oral Lesions in Pediatric Subjects: SARS-CoV-2 Infection and COVID-19 Vaccination
by Federica Di Spirito, Mario Caggiano, Maria Pia Di Palo, Maria Contaldo, Francesco D’Ambrosio, Stefano Martina and Alessandra Amato
Appl. Sci. 2022, 12(18), 8995; https://doi.org/10.3390/app12188995 - 07 Sep 2022
Cited by 23 | Viewed by 1821
Abstract
A plethora of systemic manifestations of COVID-19 and adverse reactions to COVID-19 vaccines have been described in pediatric subjects. Therefore, the present systematic review primarily aimed to assess the prevalence and macro-microscopic features of oral lesions following SARS-CoV-2 infection, grading primary oral lesions [...] Read more.
A plethora of systemic manifestations of COVID-19 and adverse reactions to COVID-19 vaccines have been described in pediatric subjects. Therefore, the present systematic review primarily aimed to assess the prevalence and macro-microscopic features of oral lesions following SARS-CoV-2 infection, grading primary oral lesions based on COVID-19 forms, in pediatric subjects. The secondary aim was to evaluate the epidemiology, clinical appearance, and histopathology of oral lesions following the WHO Emergency Use Listing approved and EMA authorized vaccines, in relation to cases and vaccine characteristics. The study protocol was compliant with the PRISMA statement and registered on PROSPERO (CRD42022351821). Case reports, case series, and observational studies were electronically searched till 27 July 2022, on MEDLINE/PubMed, Scopus, and Cochrane library databases, and the PROSPERO register. Data from nine studies describing oral lesions following viral infection and two records reporting oral lesions following vaccine administration, evaluated through the ROBINS-I tool for quality, were independently extracted and qualitatively synthesized, resulting in scarce, jeopardized, and incomplete findings. Since most of the rare lesions recorded were a part of broad-spectrum systemic disorders and syndromes and, thus. undetailed or nonspecific, further studies should assess oral lesions following SARS-CoV-2 infection and vaccination in pediatric subjects, considering novel viral variants and newly developing vaccines. Full article
(This article belongs to the Special Issue Oral-Systemic Health and Disorders: Latest Advances and Prospects)
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