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Nutrients
Special Issues
Nutrigenomics, Nutrigenetics and the Immune System: Implications for Health
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Nutrigenomics, Nutrigenetics and the Immune System: Implications for Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrigenetics and Nutrigenomics".

Deadline for manuscript submissions: closed (15 July 2021) | Viewed by 6276

Special Issue Editors

Prof. Dr. Andreu Palou

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Guest Editor
1. Laboratory of Molecular Biology, Nutrition and Biotechnology, NUO Group, Universitat de les Illes Balears, 07122 Palma, Spain
2. CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 28029 Madrid, Spain
3. Institut d’Investigació Sanitària Illes Balears (IdISBa), 07120 Palma, Spain
Interests: nutrigenomics; molecular biologygene regulation and cell signaling; leptin; metabolic programming; thermogenesis; browning; peripheral blood mononuclear cells; personalized precision nutrition; novel foods; functional foods; health claims on food
Special Issues, Collections and Topics in MDPI journals
Dr. Sebastià Galmés

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Guest Editor
Laboratory of Molecular Biology, Nutrition and Biotechnology, NUO Group, Universitat de les Illes Balears, 07122 Palma, Spain
Interests: nutrigenomics; nutrigenetics; personalized nutrition; bio-active compound; molecular biology; peripheral blood mononuclear cells; metabolic syndrome

Special Issue Information

Dear Colleagues,

The current COVID-19 pandemic has caused a global health crisis and economic devastation, highlighting the need to increase scientific knowledge about factors that can promote the optimal functioning of the immune system. The optimal nutritional balance is essential to promote health, being one of the most important factors to maintain the proper status of immune system to prevent and fight infectious diseases.

In this sense, the new knowledge in Nutritional Genomics applied to the health of the immune system is of great relevance in the current context. On the one hand, advances in Nutrigenomics help to establish the underlying biological mechanisms that sustain the relationship between nutrients and their beneficial effects on the immune system, through modulation of gene expression. On the other hand, Nutrigenetics will help to explain divergences in the immunomodulatory effect triggered by nutrients, depending on the genetic background of each individual.

Overall, scientific advances in Nutrigenomics and Nutrigenetics in the field of the state of the immune system are crucial to promote the health of the population across the implementation of Personalized Precision Nutrition strategies that allow us a greater capacity to avoid infectious diseases and defeat them with fewer complications.

Prof. Dr. Andreu Palou
Dr. Sebastià Galmés
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nutrigenetics
  • Nutrigenomics
  • Health
  • Immune System
  • Gene-nutrient interaction

Published Papers (2 papers)

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Research

21 pages, 1991 KiB  
Article
Suboptimal Consumption of Relevant Immune System Micronutrients Is Associated with a Worse Impact of COVID-19 in Spanish Populations
by Sebastià Galmés, Andreu Palou and Francisca Serra
Nutrients 2022, 14(11), 2254; https://doi.org/10.3390/nu14112254 - 27 May 2022
Cited by 6 | Viewed by 2899
Abstract
Coronavirus disease 2019 (COVID-19) has caused a global health crisis and the factors behind its differential impact on COVID-19 among populations are still being known. Geographical differences in nutrient profile could be a relevant factor, especially considering that scientific evidence supports that 10 [...] Read more.
Coronavirus disease 2019 (COVID-19) has caused a global health crisis and the factors behind its differential impact on COVID-19 among populations are still being known. Geographical differences in nutrient profile could be a relevant factor, especially considering that scientific evidence supports that 10 micronutrients are essential for proper immune system function. This study aims to evaluate these micronutrient intakes in the territories of Spain and to analyze their relationship with epidemiological indicators of COVID-19 from the first two waves of COVID-19, when neither specific vaccines nor drugs had yet come into play. Results showed that vitamin D, A, B9, and zinc intakes were particularly insufficient in Spain. The joint intake of these four micronutrients was lower in regions with the highest COVID-19 incidence and mortality, and of particular importance, was the insufficient intake of vitamin D. A pattern of food consumption associated with lower COVID-19 impact was observed. In conclusion, the results show the relevance of the optimal consumption of foods rich in essential nutrients for the immune system. Therefore, this assessment could serve to launch specific dietary recommendations to strengthen the immune system in Spanish territories to better face potential new COVID-19 variants and/or further infectious diseases. Full article
(This article belongs to the Special Issue Nutrigenomics, Nutrigenetics and the Immune System: Implications for Health)
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15 pages, 908 KiB  
Article
Association between Polygenetic Risk Scores of Low Immunity and Interactions between These Scores and Moderate Fat Intake in a Large Cohort
by Sunmin Park and Suna Kang
Nutrients 2021, 13(8), 2849; https://doi.org/10.3390/nu13082849 - 19 Aug 2021
Cited by 5 | Viewed by 2469
Abstract
White blood cell (WBC) counts represent overall immunity. However, a few studies have been conducted to explore the genetic impacts of immunity and their interaction with lifestyles. We aimed to identify genetic variants associated with a low-WBC risk and document interactions between polygenetic [...] Read more.
White blood cell (WBC) counts represent overall immunity. However, a few studies have been conducted to explore the genetic impacts of immunity and their interaction with lifestyles. We aimed to identify genetic variants associated with a low-WBC risk and document interactions between polygenetic risk scores (PRS), lifestyle factors, and nutrient intakes that influence low-WBC risk in a large hospital-based cohort. Single nucleotide polymorphisms (SNPs) were selected by genome-wide association study of participants with a low-WBC count (<4 × 109/L, n = 4176; low-WBC group) or with a normal WBC count (≥4 × 109/L, n = 36,551; control group). The best model for gene-gene interactions was selected by generalized multifactor dimensionality reduction. PRS was generated by summing selected SNP risk alleles of the best genetic model. Adjusted odds ratio (ORs) of the low-WBC group were 1.467 (1.219–1.765) for cancer incidence risk and 0.458 (0.385–0.545) for metabolic syndrome risk. Vitamin D intake, plant-based diet, and regular exercise were positively related to the low-WBC group, but smoking and alcohol intake showed an inverse association. The 7 SNPs included in the best genetic model were PSMD3_rs9898547, LCT_rs80157389, HLA-DRB1_rs532162239 and rs3097649, HLA-C rs2308575, CDKN1A_rs3176337 and THRA_rs7502539. PRS with 7 SNP model were positively associated with the low-WBC risk by 2.123-fold (1.741 to 2.589). PRS interacted with fat intake and regular exercise but not with other nutrient intakes or lifestyles. The proportion with the low WBC in the participants with high-PRS was lower among those with moderate-fat intake and regular exercise than those with low-fat intake and no exercise. In conclusion, adults with high-PRS had a higher risk of a low WBC count, and they needed to be advised to have moderate fat intake (20–25 energy percent) and regular exercise. Full article
(This article belongs to the Special Issue Nutrigenomics, Nutrigenetics and the Immune System: Implications for Health)
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