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Interactions between Dietary Flavonoids and Gut Microbiome

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (20 January 2023) | Viewed by 7373

Special Issue Editor


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Guest Editor
College of Animal Science and Technology, China Agricultural University, Beijing, China
Interests: gut; flavonoids; mucosal immunity

Special Issue Information

Dear Colleagues,

Flavonoids are a class of polyphenols that widely exist in diets in the form of fruits, vegetables, tea, etc. Dietary flavonoids have gained more attention in recent years due to their various bioactive activities, such as anti-inflammation, antioxidation, and being able to ameliorate intestinal barrier function. These suggest that the consumption of dietary flavonoids might reduce the risk of inflammatory bowel diseases and diseases caused by reactive oxygen species. Upon ingestion, flavonoids are digested by enzymes in the small intestine to increase their bioavailability. However, most flavonoids are metabolized by gut microbiota. It has also been confirmed that the addition of flavonoids alters the composition of intestinal microbiome, which might be associated with their bioactivities. The goal of the Special Issue, “Interactions between Dietary Flavonoids and Gut Microbiome” is to focus on how dietary flavonoids and the gut microbiome interact with each other and the underlying mechanism of their interactions.

Dr. Bingkun Zhang
Guest Editor

Manuscript Submission Information

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Keywords

  • diet
  • flavonoids
  • intestinal barrier function
  • gut microbiota
  • interaction

Published Papers (2 papers)

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Research

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17 pages, 837 KiB  
Article
Microbial Metabolism of Naringin and the Impact on Antioxidant Capacity
by Xuan Zeng, Yuying Zheng, Yan He, Jiashuo Zhang, Wei Peng and Weiwei Su
Nutrients 2022, 14(18), 3765; https://doi.org/10.3390/nu14183765 - 13 Sep 2022
Cited by 17 | Viewed by 2497
Abstract
Naringin is a dietary flavonoid glycoside with broad bioactivities, and it has been found to undergo extensive microbial metabolism in human gut. Microbial metabolites are believed to play an important role in the overall bioactivity of naringin. However, knowledge is scarce about its [...] Read more.
Naringin is a dietary flavonoid glycoside with broad bioactivities, and it has been found to undergo extensive microbial metabolism in human gut. Microbial metabolites are believed to play an important role in the overall bioactivity of naringin. However, knowledge is scarce about its microbial metabolism in laboratory rats, which are the most commonly used animal model for naringin-related biomedical studies. Herein, we profiled the microbial metabolism of naringin in rat by an in vitro anaerobic fermentation combined with LC-MS/MS methods. A total of 35 microbial metabolites were identified, and corresponding metabolic pathways were proposed. Naringin and its metabolites were further quantified in fermentation samples. Rhoifolin, neoeriocitrin, neohesperidin, naringenin, methylated naringin, and hydroxylated naringin were detected as the primary microbial metabolites. Moreover, antioxidant capacity assays suggested that fermentation-associated microbial metabolites exhibited higher antioxidant activity than original naringin. Obtained results contribute to a more comprehensive understanding of the microbial metabolism and antioxidant capacity of naringin. Full article
(This article belongs to the Special Issue Interactions between Dietary Flavonoids and Gut Microbiome)
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Review

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28 pages, 1742 KiB  
Review
Protective Effect of Anthocyanins against Neurodegenerative Diseases through the Microbial-Intestinal-Brain Axis: A Critical Review
by Hao Zhong, Jie Xu, Mengyu Yang, Muhammad Hussain, Xiaofeng Liu, Fengqin Feng and Rongfa Guan
Nutrients 2023, 15(3), 496; https://doi.org/10.3390/nu15030496 - 18 Jan 2023
Cited by 12 | Viewed by 4310
Abstract
With the increase in human mean age, the prevalence of neurodegenerative diseases (NDs) also rises. This negatively affects mental and physiological health. In recent years, evidence has revealed that anthocyanins could regulate the functioning of the central nervous system (CNS) through the microbiome-gut-brain [...] Read more.
With the increase in human mean age, the prevalence of neurodegenerative diseases (NDs) also rises. This negatively affects mental and physiological health. In recent years, evidence has revealed that anthocyanins could regulate the functioning of the central nervous system (CNS) through the microbiome-gut-brain axis, which provides a new perspective for treating NDs. In this review, the protective effects and mechanisms of anthocyanins against NDs are summarized, especially the interaction between anthocyanins and the intestinal microbiota, and the microbial-intestinal-brain axis system is comprehensively discussed. Moreover, anthocyanins achieve the therapeutic purpose of NDs by regulating intestinal microflora and certain metabolites (protocateic acid, vanillic acid, etc.). In particular, the inhibitory effect of tryptophan metabolism on some neurotransmitters and the induction of blood-brain barrier permeability by butyrate production has a preventive effect on NDs. Overall, it is suggested that microbial-intestinal-brain axis may be a novel mechanism for the protective effect of anthocyanins against NDs. Full article
(This article belongs to the Special Issue Interactions between Dietary Flavonoids and Gut Microbiome)
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