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Nutritional Strategies to Promote Muscle Mass and Function in Health and Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Sports Nutrition".

Deadline for manuscript submissions: closed (5 April 2024) | Viewed by 1681

Special Issue Editors


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Guest Editor
College of Health Science, University of Memphis, Memphis, TN, USA
Interests: muscle metabolism; metabolic dysfunction; cachexia; nutrition; exercise
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Guest Editor
School of Kinesiology Administration, College of Education & Human Development, University of Louisiana at Lafayette, Lafayette, LA, USA
Interests: cancer cachexia; muscle plasticity; exercise; signal transduction; sarcopenia

Special Issue Information

Dear Colleagues,

Nutritional interventions have been widely utilized to help promote skeletal muscle mass gain and prevent muscle atrophy. Coupling nutritional interventions with exercise has been shown to enhance muscle protein synthesis rates and muscle hypertrophy in healthy individuals. Similar strategies have been used in aging and disease with a variety of effects. While there is an extensive body of literature examining the effects of protein and amino acid consumption on muscle mass, there are many nutritional interventions that may support the maintenance of muscle mass or function. It is well established that maintenance of muscle mass is an important aspect of many disease conditions, and loss of muscle mass is associated with increased mortality in diseased populations. Identifying and understanding the role that various nutritional interventions play in muscle homeostasis can lead to enhancements for both athletes and clinicians working with diseased populations. This Special Issue aims to collect the latest information about various nutritional strategies that can aid in the promotion or maintenance of muscle mass and function in both healthy and diseased populations.

Dr. Melissa Puppa
Dr. Shuichi Sato
Guest Editors

Manuscript Submission Information

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Keywords

  • skeletal muscle
  • nutrition
  • supplements
  • protein synthesis
  • proteostasis
  • muscle mass
  • hypertrophy
  • atrophy

Published Papers (1 paper)

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Research

16 pages, 11575 KiB  
Article
Leucine Supplementation Exacerbates Morbidity in Male but Not Female Mice with Colorectal Cancer-Induced Cachexia
by Eleanor R. Schrems, Wesley S. Haynie, Richard A. Perry, Jr., Francielly Morena, Ana Regina Cabrera, Megan E. Rosa-Caldwell, Nicholas P. Greene and Tyrone A. Washington
Nutrients 2023, 15(21), 4570; https://doi.org/10.3390/nu15214570 - 27 Oct 2023
Cited by 1 | Viewed by 1270
Abstract
Cancer cachexia (CC) is a multifactorial wasting syndrome characterized by a significant loss in lean and/or fat mass and represents a leading cause of mortality in cancer patients. Nutraceutical treatments have been proposed as a potential treatment strategy to mitigate cachexia-induced muscle wasting. [...] Read more.
Cancer cachexia (CC) is a multifactorial wasting syndrome characterized by a significant loss in lean and/or fat mass and represents a leading cause of mortality in cancer patients. Nutraceutical treatments have been proposed as a potential treatment strategy to mitigate cachexia-induced muscle wasting. However, contradictory findings warrant further investigation. The purpose of this study was to determine the effects of leucine supplementation on skeletal muscle in male and female ApcMin/+ mice (APC). APC mice and their wild-type (WT) littermates were given normal drinking water or 1.5% leucine-supplemented water (n = 4–10/group/sex). We measured the gene expression of regulators of inflammation, protein balance, and myogenesis. Leucine treatment lowered survival rates, body mass, and muscle mass in males, while in females, it had no effect on body or muscle mass. Leucine treatment altered inflammatory gene expression by lowering Il1b 87% in the APC group and decreasing Tnfa 92% in both WT and APC males, while it had no effect in females (p < 0.05). Leucine had no effect on regulators of protein balance and myogenesis in either sex. We demonstrated that leucine exacerbates moribundity in males and is not sufficient for mitigating muscle or fat loss during CC in either sex in the ApcMin/+ mouse. Full article
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