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We Are What We Eat: The Role of Food Intake...
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We Are What We Eat: The Role of Food Intake on Human Metabolome

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (5 February 2024) | Viewed by 3900

Special Issue Editors

Dr. Marta P. Silvestre

E-Mail Website
Guest Editor
NOVA Medical School, NOVA University of Lisbon, 1169-056 Lisbon, Portugal
Interests: glycaemia; human nutrition; metabolic disease; microbiome
Dr. Louise Lu

E-Mail Website
Guest Editor
School of Biological Sciences, University of Auckland, Auckland 1024, New Zealand
Interests: human nutrition; glycaemia; type 2 diabetes; obesity; carbohydrates
Dr. Diana Teixeira

E-Mail Website
Guest Editor
NOVA Medical School, NOVA University of Lisbon, 1169-056 Lisbon, Portugal
Interests: adipose tissue; human nutrition; obesity; metabolic disease; microbiome

Special Issue Information

Dear Colleagues,

Nutrients are pathways by which food intake shapes metabolism and body composition. Both nutrients and their metabolites constitute key biological and functional outputs linking metabolic pathways with health and disease. Advances in research methods and techniques, such as metabolomics, have made it possible to characterize the human and animal metabolome and how it changes in different food and nutritional contexts or following dietary interventions. This can strengthen research and nutritional science by: a) defining and validating biomarkers of food intake; and b) objectively interpreting how food intake and nutrition impact health and disease. 

This Special Issue aims to present outstanding research on how diet/ food intake relates to and impacts circulating and tissue-specific metabolites, characterizing metabolic responses to nutrition in the context of health and disease. It will cover: a) studies analyzing metabolic changes following nutritional/dietary interventions in humans and animal models; b) studies focusing on the identification and validation of biomarkers for food intake; and c) studies investigating shifts in metabolism and quantification of certain molecules under specific nutritional contexts. Finally, we highly encourage authors to submit systematic reviews and meta-analysis focusing on the association between the nutrition/dietary intake and circulating and tissue-specific metabolites as well as the impact of specific nutrients/nutraceutical supplements/dietary patterns/functional foods on changes in related metabolites.

Dr. Marta P. Silvestre
Dr. Louise Lu
Dr. Diana Teixeira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • diet
  • biomarkers of food intake
  • nutrition-related biomarkers
  • personalized nutrition
  • precision nutrition
  • nutraceutical
  • dietary pattern
  • food intake

Published Papers (2 papers)

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Research

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17 pages, 4648 KiB  
Article
Supplementing Low-Sodium Bicarbonate–Calcic (Lete)® Water: Effects in Women on Bone and Systemic Metabolism
by Carmen Marino, Imma Pagano, Giuseppe Castaldo, Manuela Grimaldi, Maria D’Elia, Angelo Santoro, Aurelio Conte, Paola Molettieri, Chiara Parisella, Michela Buonocore, Anna Maria D’Ursi and Luca Rastrelli
Metabolites 2023, 13(11), 1109; https://doi.org/10.3390/metabo13111109 - 24 Oct 2023
Viewed by 1313
Abstract
Calcium (Ca) represents about 40% of the total mineral mass, mainly in the bone, providing mechanical strength to the skeleton and teeth. An adequate Ca intake is necessary for bone growth and development in children and adolescents and for maintaining bone mineral loss [...] Read more.
Calcium (Ca) represents about 40% of the total mineral mass, mainly in the bone, providing mechanical strength to the skeleton and teeth. An adequate Ca intake is necessary for bone growth and development in children and adolescents and for maintaining bone mineral loss in elderly age. Ca deficiency predisposes to osteopenia and osteoporosis. Healthy nutrition, including an adequate intake of Ca-rich food, is paramount to prevent and cure osteoporosis. Recently, several clinical studies have demonstrated that, in conditions of Ca dysmetabolism, Ca-rich mineral water is beneficial as a valuable source of Ca to be used as an alternative to caloric Ca-rich dairy products. Although promising, these data have been collected from small groups of participants. Moreover, they mainly regard the effect of Ca-rich mineral water on bone metabolism. In contrast, an investigation of the effect of Ca supplementation on systemic metabolism is needed to address the spreading of systemic metabolic dysfunction often associated with Ca dysmetabolism. In the present study, we analyzed urine and blood sera of 120 women in perimenopausal condition who were subjected for six months to 2l daily consumption of bicarbonate–calcium mineral water marketed under ®Lete. Remarkably, this water, in addition to being rich in calcium and bicarbonate, is also low in sodium. A complete set of laboratory tests was carried out to investigate whether the specific water composition was such to confirm the known therapeutic effects on bone metabolism. Second, but not least, urine and blood sera were analyzed using NMR-based metabolomic procedures to investigate, other than the action on Ca metabolism, potential system-wide metabolic effects. Our data show that Lete water is a valid supplement for compensating for Ca dysmetabolism and preserving bone health and integrity. Full article
(This article belongs to the Special Issue We Are What We Eat: The Role of Food Intake on Human Metabolome)
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Review

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18 pages, 601 KiB  
Review
Potential Benefits of Omega-3 Polyunsaturated Fatty Acids (N3PUFAs) on Cardiovascular Health Associated with COVID-19: An Update for 2023
by Louise Weiwei Lu, Siew-Young Quek, Shi-Ping Lu and Jie-Hua Chen
Metabolites 2023, 13(5), 630; https://doi.org/10.3390/metabo13050630 - 5 May 2023
Cited by 1 | Viewed by 1961
Abstract
The accumulating literature demonstrates that omega-3 polyunsaturated fatty acid (n-3 polyunsaturated fatty acid, N3PUFA) can be incorporated into the phospholipid bilayer of cell membranes in the human body to positively affect the cardiovascular system, including improving epithelial function, decreasing coagulopathy, and attenuating uncontrolled [...] Read more.
The accumulating literature demonstrates that omega-3 polyunsaturated fatty acid (n-3 polyunsaturated fatty acid, N3PUFA) can be incorporated into the phospholipid bilayer of cell membranes in the human body to positively affect the cardiovascular system, including improving epithelial function, decreasing coagulopathy, and attenuating uncontrolled inflammatory responses and oxidative stress. Moreover, it has been proven that the N3PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are precursors of some potent endogenous bioactive lipid mediators that mediate some favorable effects attributed to their parent substances. A dose–response relationship between increased EPA and DHA intake and reduced thrombotic outcomes has been reported. The excellent safety profile of dietary N3PUFAs makes them a prospective adjuvant treatment for people exposed to a higher risk of cardiovascular problems associated with COVID-19. This review presented the potential mechanisms that might contribute to the beneficial effects of N3PUFA and the optimal form and dose applied. Full article
(This article belongs to the Special Issue We Are What We Eat: The Role of Food Intake on Human Metabolome)
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