Dear Colleagues,

The complex orchestration of molecular mechanisms in gastrointestinal (GI) disorders has long been a topic of intrigue in the world of medical research. With the advent of advanced genomics and proteomics technologies, we are now poised to uncover the intricate genetic and protein interactions underpinning various GI disorders.

Traditionally, GI disorders were understood primarily through their physiological manifestations and a limited understanding of their molecular basis. However, the past two decades have seen a seismic shift in this paradigm. With the completion of the Human Genome Project at the turn of the century and the subsequent development of high-throughput proteomic techniques, the scientific community began to peer deeper into the genetic and proteomic landscapes of GI disorders.

This Special Issue, “Genomics and Proteomics in Gastrointestinal Disorders”, aims to collate and present cutting-edge research that bridges the knowledge gap between genomics, proteomics, and the clinical manifestations of GI disorders. It seeks to shed light on the underlying molecular mechanisms, offer potential biomarkers for diagnosis and prognosis, and possibly pave the way for personalized therapeutic strategies.

Recent advancements in next-generation sequencing, mass spectrometry, and bioinformatics tools have revolutionized our understanding of the genomic and proteomic profiles associated with GI disorders. This Special Issue will highlight such advancements, focusing on their implications in elucidating disease pathways, predicting disease progression, and guiding therapeutic interventions.

We invite researchers from across the globe to submit their original articles, review articles, case studies, and brief reports. Topics of interest include, but are not limited to:

• Genetic and proteomic markers for early diagnosis of GI disorders;
• Role of genomics and proteomics in understanding disease pathogenesis;
• The interplay between the gut microbiome, genomics and proteomics;
• Translational research bridging molecular findings with clinical outcomes;
• Personalized therapeutic strategies based on genomic and proteomic profiles.

In conclusion, this Special Issue endeavors to provide a comprehensive platform for the latest insights into the role of genomics and proteomics in gastrointestinal disorders, fostering collaboration and driving developments in this critical area of medicine.

Dr. Cristian George Ţieranu
Prof. Dr. Adrian Saftoiu
Guest Editors

Manuscript Submission Information

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• genomics
• transcriptomics
• proteomics
• autoimmune
• gastrointestinal