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Cancers
Special Issues
Endoscopic Ultrasound in Gastrointestinal Cancers
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Endoscopic Ultrasound in Gastrointestinal Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: closed (3 January 2024) | Viewed by 3764

Special Issue Editors

Dr. Irina M. Cazacu

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Guest Editor
1. Department of Oncology, Fundeni Clinical Institute, 022328 Bucharest, Romania
2. Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
Interests: digestive oncology; cancer biomarkers; cancer screening; pancreatic cancer; clonal hematopoiesis
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Adrian Saftoiu

E-Mail Website
Guest Editor
Department of Gastroenterology, Research Center of Gastroenterology and Hepatology, Universitatea de Medicina si Farmacie Craiova, Craova, Romania
Interests: gastroenterology; chronic pancreatitis; elastography; EUS; liver cirrhosis; pancreatic cancer; endoscopic retrograde cholangiopancreatography; pancreatic diseases; hepatocellular carcinoma; gastric cancer
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Manoop S. Bhutani

E-Mail Website
Guest Editor
The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Interests: gastroenterology

Special Issue Information

Dear Colleagues,

Endoscopic ultrasound (EUS) represents a valuable addition to imaging modalities, with a wide range of diagnostic and therapeutic applications for gastrointestinal and pancreatico-biliary diseases. It permits high-resolution imaging of the intramural GI tract and extramural structures and allows for real-time EUS-guided fine-needle aspiration/biopsy (EUS-FNA/FNB) for pathological confirmation. There has been a tremendous journey for EUS over the last few decades, with a transition from a purely diagnostic tool to a therapeutic method. The interventional capacity of EUS continues to progress considerably with the advent of new imaging techniques.

The development of EUS has offered novel perspectives in gastrointestinal oncology, from lesion imaging, staging, and sampling to advanced therapeutic and enhanced imaging techniques including EUS elastography, contrast-enhanced harmonic EUS, image fusion EUS, and artificial intelligence.

This Special Issue aims to highlight recent advances in EUS for the management of gastrointestinal malignancies. The scope is deliberately broad to allow contributions on diverse aspects of the topic. We invite our colleges to submit original articles or reviews on techniques that have been developed in recent years for enhanced imaging with EUS, including elastography, contrast enhancement, image fusion, and artificial intelligence.

Dr. Irina M. Cazacu
Prof. Dr. Adrian Saftoiu
Prof. Dr. Manoop S. Bhutani
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastrointestinal cancers
  • endoscopic ultrasound
  • fine-needle aspiration
  • fine-needle biopsy
  • elastography
  • contrast enhancement
  • image fusion
  • artificial intelligence

Published Papers (2 papers)

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18 pages, 7061 KiB  
Article
Validation of a Novel EUS-FNB-Derived Organoid Co-Culture System for Drug Screening in Patients with Pancreatic Cancer
by Simon Ezban Grützmeier, Bojan Kovacevic, Peter Vilmann, Charlotte Vestrup Rift, Linea Cecilie Melchior, Morten Orebo Holmström, Lene Brink, Hazem Hassan, John Gásdal Karstensen, Hanne Grossjohann, Deepthi Chiranth, Anders Toxværd, Carsten Palnæs Hansen, Estrid Høgdall, Jane Preuss Hasselby and Pia Klausen
Cancers 2023, 15(14), 3677; https://doi.org/10.3390/cancers15143677 - 19 Jul 2023
Cited by 3 | Viewed by 2002
Abstract
Cancer-associated fibroblasts (CAFs) have been shown to impact the chemosensitivity of patient-derived tumor organoids (PDTOs). However, the published literature comparing PDTO response to clinical outcome does not include CAFs in the models. Here, a co-culture model was created using PDTOs and CAFs derived [...] Read more.
Cancer-associated fibroblasts (CAFs) have been shown to impact the chemosensitivity of patient-derived tumor organoids (PDTOs). However, the published literature comparing PDTO response to clinical outcome does not include CAFs in the models. Here, a co-culture model was created using PDTOs and CAFs derived from endoscopic ultrasound-guided fine-needle biopsies (EUS-FNBs) for potential use in drug screening applications. Co-cultures were established, and growth was compared to monocultures using image metrics and a commercially available assay. We were able to establish and expand validated malignant PDTOs from 19.2% of adenocarcinomas from EUS-FNBs. CAFs could be established from 25% of the samples. The viability of PDTOs in the mixed cell co-culture could be isolated using image metrics. The addition of CAFs promoted PDTO growth in half of the established co-cultures. These results show that co-cultures can be established from tiny amounts of tissue provided by EUS-FNB. An increased growth of PDTOs was shown in co-cultures, suggesting that the present setup successfully models CAF–PDTO interaction. Furthermore, we demonstrated that standard validation techniques may be insufficient to detect contamination with normal cells in PDTO cultures established from primary tumor core biopsies. Full article
(This article belongs to the Special Issue Endoscopic Ultrasound in Gastrointestinal Cancers)
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13 pages, 886 KiB  
Systematic Review
Performance and Safety of EUS Ablation Techniques for Pancreatic Cystic Lesions: A Systematic Review and Meta-Analysis
by Apostolis Papaefthymiou, Gavin J. Johnson, Marcello Maida, Paraskevas Gkolfakis, Daryl Ramai, Antonio Facciorusso, Marianna Arvanitakis, Alexander Ney, Giuseppe K. Fusai, Adrian Saftoiu, Daniela Tabacelia, Simon Phillpotts, Michael H. Chapman, George J. Webster and Stephen P. Pereira
Cancers 2023, 15(9), 2627; https://doi.org/10.3390/cancers15092627 - 05 May 2023
Cited by 5 | Viewed by 1450
Abstract
Background: Pancreatic cystic lesions (PCL) represent an increasingly diagnosed condition with significant burden to patients’ lives and medical resources. Endoscopic ultrasound (EUS) ablation techniques have been utilized to treat focal pancreatic lesions. This systematic review with meta-analysis aims to assess the efficacy of [...] Read more.
Background: Pancreatic cystic lesions (PCL) represent an increasingly diagnosed condition with significant burden to patients’ lives and medical resources. Endoscopic ultrasound (EUS) ablation techniques have been utilized to treat focal pancreatic lesions. This systematic review with meta-analysis aims to assess the efficacy of EUS ablation on PCL in terms of complete or partial response and safety. Methods: A systematic search in Medline, Cochrane and Scopus databases was performed in April 2023 for studies assessing the performance of the various EUS ablation techniques. The primary outcome was complete cyst resolution, defined as cyst disappearance in follow-up imaging. Secondary outcomes included partial resolution (reduction in PCL size), and adverse events rate. A subgroup analysis was planned to evaluate the impact of the available ablation techniques (ethanol, ethanol/paclitaxel, radiofrequency ablation (RFA), and lauromacrogol) on the results. Meta-analyses using a random effects model were conducted and the results were reported as percentages with 95% confidence intervals (95%CI). Results: Fifteen studies (840 patients) were eligible for analysis. Complete cyst resolution after EUS ablation was achieved in 44% of cases (95%CI: 31–57; 352/767; I2 = 93.7%), and the respective partial response rate was 30% (95%CI: 20–39; 206/767; I2 = 86.1%). Adverse events were recorded in 14% (95%CI: 8–20; 164/840; I2 = 87.2%) of cases, rated as mild in 10% (95%CI: 5–15; 128/840; I2 = 86.7%), and severe in 4% (95%CI: 3–5; 36/840; I2 = 0%). The subgroup analysis for the primary outcome revealed rates of 70% (95%CI: 64–76; I2 = 42.3%) for ethanol/paclitaxel, 44% (95%CI: 33–54; I2= 0%) for lauromacrogol, 32% (95%CI: 27–36; I2 = 88.4%) for ethanol, and 13% (95%CI: 4–22; I2 = 95.8%) for RFA. Considering adverse events, the ethanol-based subgroup rated the highest percentage (16%; 95%CI: 13–20; I2 = 91.0%). Conclusion: EUS ablation of pancreatic cysts provides acceptable rates of complete resolution and a low incidence of severe adverse events, with chemoablative agents yielding higher performance rates. Full article
(This article belongs to the Special Issue Endoscopic Ultrasound in Gastrointestinal Cancers)
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