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Special Issue "Current and Emerging Treatment Options in Sinus and Nasal Diseases"

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A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Otolaryngology".

Deadline for manuscript submissions: 20 September 2023 | Viewed by 3639

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Special Issue Editors

Prof. Dr. Lei Cheng

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Guest Editor

Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
Interests: allergic rhinitis; nasal polyps; tinnitus; SNPs; noncoding RNA; allergen immunotherapy; probiotics

Prof. Dr. Chengshuo Wang

E-Mail Website
Guest Editor

Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing 100730, China; Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China
Interests: chronic rhinosinusitis; nasal polyps; allergic rhinitis; allergen immunotherapy; sinonasal inverted

Special Issue Information

Dear Colleagues,

Sinus and nasal diseases affect billions of people in the world, and account for more than one million outpatient visits a year, resulting in countless time lost. In the past, sinus surgery was invasive, often performed through external incisions, and thus was associated with significant pain. Today, a range of emerging skills have been applied in clinical practice, providing doctors with new insights and methods to treat this kind of disease.

The purpose of this Special Issue is to review current advances and controversies in the treatment of patients with sinus and nasal diseases, the effects of treatment on a patient’s quality of life, and the expansion of surgical and other approaches to sinus and nasal diseases.

Prof. Dr. Lei Cheng
Prof. Dr. Chengshuo Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

chronic rhinosinusitis
nasal polyps
allergic and nonallergic rhinitis
olfactory disorders
sinonasal inverted papilloma
sinonasal malignancies
endoscopic sinus surgery
biologic therapy

Published Papers (5 papers)

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Editorial

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Open AccessEditorial

Current and Emerging Treatment Options in Sinus and Nasal Diseases: Surgical Challenges and Therapeutic Perspectives

Xiao-Ying Zhao

Ming Chen

and

Lei Cheng

J. Clin. Med. 2023, 12(4), 1485; https://doi.org/10.3390/jcm12041485 - 13 Feb 2023

Viewed by 832

Abstract

Chronic rhinosinusitis (CRS), one of the most prevalent health problems worldwide, is defined as a chronic inflammation of the nasal and paranasal sinuses mucosa persisting for more than 12 weeks [...] Full article

(This article belongs to the Special Issue Current and Emerging Treatment Options in Sinus and Nasal Diseases)

Open AccessEditorial

Current and Emerging Treatment Options in Sinus and Nasal Diseases: A Promising Future in the Appropriate Therapies

Lin Lin

and

Lei Cheng

J. Clin. Med. 2022, 11(24), 7398; https://doi.org/10.3390/jcm11247398 - 14 Dec 2022

Viewed by 637

Abstract

Chronic rhinosinusitis (CRS) is an inflammatory condition of the nose and paranasal sinuses defined by clinical symptoms, including two or more symptoms, one of which should be either nasal blockage or nasal discharge with or without facial pain/pressure or reduction in/loss of sense [...] Read more.

(This article belongs to the Special Issue Current and Emerging Treatment Options in Sinus and Nasal Diseases)

Research

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Open AccessArticle

Factors Influencing Recurrence after Surgical Treatment of Odontogenic Maxillary Sinusitis: An Analysis from the Oral and Maxillofacial Surgery Point of View

Oliver Christian Thiele

Robert Andreas Mischkowski

and

Mario Scheurer

J. Clin. Med. 2023, 12(11), 3670; https://doi.org/10.3390/jcm12113670 - 25 May 2023

Viewed by 245

Abstract

The aim of the study was to determine the factors influencing the development of recurrence after the surgical treatment of odontogenic maxillary sinusitis in an oral and maxillofacial surgery clinic over a 7-year period. Demographic and anamnesis data, clinical and radiological findings, treatment and outcome were analyzed. A multivariable analysis was performed to find associations between patient age, causative focus, surgical access for sinus revision, multilayer closure with a buccal fat pad, inferior meatal antrostomy (IMA) for temporary sinus drainage and sinusitis recurrence. A total of 164 patients with a mean age of 51.7 years were included. Sinusitis recurrence was observed in nine patients (5.48%) within 6 months after primary surgery. No significant correlation was detected between patient age, causative focus, surgical access for sinus revision, multilayer closure with a buccal fat pad, IMA for sinus drainage and the development of recurrence (p > 0.05). Patients with a history of antiresorptive-related osteonecrosis of the jaw showed a significant tendency toward disease recurrence (p = 0.0375). In conclusion, except for antiresorptive administration, none of the investigated variables were related to a higher risk of sinusitis recurrence. We encourage a combined approach of intraoral removal of the infective focus and sinus drainage via FESS, as well as an individual treatment decision in a multidisciplinary setting with collaboration between dentistry, maxillofacial surgery and otorhinolaryngology to avoid sinusitis recurrence. Full article

(This article belongs to the Special Issue Current and Emerging Treatment Options in Sinus and Nasal Diseases)

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Open AccessArticle

Identifying Residual Psychological Symptoms after Nasal Reconstruction Surgery in Patients with Empty Nose Syndrome

and

J. Clin. Med. 2023, 12(7), 2635; https://doi.org/10.3390/jcm12072635 - 31 Mar 2023

Cited by 1 | Viewed by 639

Abstract

Background: Empty nose syndrome (ENS) is a syndrome of paradoxical nasal obstruction that is thought to be mostly caused by inappropriate turbinate procedures. This study aimed to investigate depression- and anxiety-associated psychological symptoms in patients with ENS before and after surgical reconstruction, and to compare them with those of control subjects. Methods: Patients with ENS were prospectively enrolled. The Sino-Nasal Outcome Test-25 (SNOT-25), Empty Nose Syndrome 6-item questionnaire (ENS6Q), Beck Depression Inventory-II (BDI-II), and Beck Anxiety Inventory (BAI) were used to evaluate the participants before and after reconstruction surgery with submucosal Medpor implantation (Stryker, Kalamazoo, MI), as well as control subjects at enrollment. Results: Forty patients with ENS and forty age- and sex-matched controls were recruited. Patients with ENS experienced significant improvement in SNOT-25, ENS6Q, BDI-II, and BAI scores after surgery, but all were significantly greater than those in the control group. Nine patients with ENS (22.5%) had postoperative residual psychological symptoms. Preoperative BDI-II and BAI scores were significant predictors of postoperative residual psychological symptoms. The optimal cut-off value was BDI-II > 28.5 (sensitivity, 77.8%; specificity, 77.4%) in receiver operating characteristic curve analysis. Conclusions: The nasal and psychological evaluations in patients with ENS significantly improved after nasal reconstruction surgery, but both were significantly greater than those in the control group. Identifying individuals who may experience postoperative residual symptoms and providing a multimodal approach, including surgical reconstruction and psychiatric treatment, are suggested. Full article

(This article belongs to the Special Issue Current and Emerging Treatment Options in Sinus and Nasal Diseases)

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Review

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Open AccessReview

Therapeutic Strategies to Prevent the Recurrence of Nasal Polyps after Surgical Treatment: An Update and In Vitro Study on Growth Inhibition of Fibroblasts

Angela Rizzi

Luca Gammeri

Raffaele Cordiano

Mariagrazia Valentini

Michele Centrone

Sabino Marrone

Riccardo Inchingolo

Franziska Michaela Lohmeyer

and

J. Clin. Med. 2023, 12(8), 2841; https://doi.org/10.3390/jcm12082841 - 13 Apr 2023

Viewed by 810

Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) is the most bothersome phenotype of chronic rhinosinusitis, which is typically characterized by a Type 2 inflammatory reaction, comorbidities and high rates of nasal polyp recurrence, causing severe impact on quality of life. Nasal polyp recurrence rates, defined as the number of patients undergoing revision endoscopic sinus surgery, are 20% within a 5 year period after surgery. The cornerstone of CRSwNP management consists of anti-inflammatory treatment with local corticosteroids. We performed a literature review regarding the therapeutic strategies used to prevent nasal polyp recurrence after surgical treatment. Finally, we report an in vitro study evaluating the efficacy of lysine–acetylsalicylic acid and other non-steroidal anti-inflammatory drugs (ketoprofen and diclofenac) on the proliferation of fibroblasts, obtained from nasal polyp tissue samples. Our study demonstrates that diclofenac, even more so than lysine–acetylsalicylic acid, significantly inhibits fibroblast proliferation and could be considered a valid therapeutic strategy in preventing CRSwNP recurrence. Full article

(This article belongs to the Special Issue Current and Emerging Treatment Options in Sinus and Nasal Diseases)

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Special Issue "Current and Emerging Treatment Options in Sinus and Nasal Diseases"

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