Nanovehicles: Current Developments and Future Perspectives
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".
Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 2687
Special Issue Editors
2. LAQV-REQUIMTE, Galenic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
Interests: polymeric micelles; micelleplexes; controlled release; gene therapy; cancer; nanotechnology
Special Issues, Collections and Topics in MDPI journals
Interests: nanomedicine; polymer micelles; cancer therapy; gene delivery; NMR spectroscopy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the past decades the application of nanovehicles for disease therapy has attracted ever growing attention from researchers, and funding and regulating agencies. The concept of delivering therapeutic and/or imaging molecules (conventional drugs, nucleic acids, gene editing machines, proteins) with the help of nanotechnology emerged from the start as a promising strategy to overcome pharmacological and toxicological issues related with conventional therapy, and to improve therapeutic outcomes. A wide range of nanovehicles based on natural and synthetic polymers and non-polymer materials is extensively investigated to improve drug solubilization, passive and active targeting of disease sites, and controlled drug release responsive to local stimuli. Despite the significant efforts invested in design of nanovehicles and the understanding of their interactions with biological systems, only a handful of therapeutic nanoformulations fulfilled the conditions for clinical application. The most recent world-wide application of COVID-19 mRNA-based nanovaccine emphasized certain safety issues, and brought yet again the interactions of therapeutic and nanovehicle components into the forefront. The collection of original and review papers of this Special Issue aims to offer the multidisciplinary insight into the latest trends and challenges in therapeutic nanovehicle development, the fundamental understanding of their interactions with biological systems, as well as the latest solutions to overcoming the biological barriers. The molecular basis of the translational potential and interactions of nanovehicles and their therapeutic load with human organism will have a prominent place in this Issue.
Prof. Dr. Ana Figueiras
Dr. Ivana Jarak
Guest Editors
Manuscript Submission Information
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Keywords
- nanovehicles
- biological barriers
- immunogenicity
- protein corona
- nanomedicine toxicity and safety
- biodistribution
- combination therapy
