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Pharmaceutics
Special Issues
Advances in Polymeric Micelles for Therapeutic Applications
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Advances in Polymeric Micelles for Therapeutic Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 9966

Special Issue Editors

Dr. Ana Figueiras

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Guest Editor
1. Galenic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
2. LAQV-REQUIMTE, Galenic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
Interests: polymeric micelles; micelleplexes; controlled release; gene therapy; cancer; nanotechnology
Special Issues, Collections and Topics in MDPI journals
Dr. Ivana Jarak

E-Mail Website
Guest Editor
Galenic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
Interests: nanomedicine; polymer micelles; cancer therapy; gene delivery; NMR spectroscopy
Special Issues, Collections and Topics in MDPI journals
Dr. Cátia Domingues

E-Mail Website
Guest Editor
1. Galenic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
2. LAQV-REQUIMTE, Galenic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
3. Faculty of Medicine, Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO), University of Coimbra, 3000-548 Coimbra, Portugal
Interests: nanomedicine; polymer micelles; cancer therapy; gene delivery; micelleplexes; natural compounds; immunotherapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is collecting selected papers from the first “Advances in Polymeric Micelles for therapeutic applications” conference. The conference is organized by the Faculty of Pharmacy, University of Coimbra, and will be held in Coimbra on 24 January 2022, both in person and online. Registration is free of charge but is mandatory for participation, and the deadline for registration is 22 January 2022 at https://forms.gle/WZsdZx4r1sY21u669.

The meeting will focus on the latest advances and current challenges in the application of therapeutic polymeric micelles. The chosen topics will be presented by renowned experts in the field, and a special opportunity will be given to young scientists to present their work.

The participants are cordially invited to contribute to this Special Issue of Pharmaceutics with original research or review papers.

The following topics will be covered:

  • Synthesis and characterization of polymeric micelles
  • Therapeutic and diagnostic application of polymeric micelles.

Prof. Dr. Ana Figueiras
Dr. Ivana Jarak
Dr. Cátia Domingues
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

This Special Issue is collecting selected papers from the first “Advances in Polymeric Micelles for therapeutic applications” conference. The conference is organized by the Faculty of Pharmacy, University of Coimbra, and will be held in Coimbra on 24 January 2022, both in person and online. Registration is free of charge but is mandatory for participation, and the deadline for registration is 22 January 2022 at https://forms.gle/WZsdZx4r1sY21u669.

The meeting will focus on the latest advances and current challenges in the application of therapeutic polymeric micelles. The chosen topics will be presented by renowned experts in the field, and a special opportunity will be given to young scientists to present their work.

The participants are cordially invited to contribute to this Special Issue of Pharmaceutics with original research or review papers.

The following topics will be covered:

  • Synthesis and characterization of polymeric micelles
  • Therapeutic and diagnostic application of polymeric micelles.

Published Papers (2 papers)

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Review

27 pages, 2825 KiB  
Review
New Advances in Biomedical Application of Polymeric Micelles
by Ana Figueiras, Cátia Domingues, Ivana Jarak, Ana Isabel Santos, Ana Parra, Alberto Pais, Carmen Alvarez-Lorenzo, Angel Concheiro, Alexander Kabanov, Horacio Cabral and Francisco Veiga
Pharmaceutics 2022, 14(8), 1700; https://doi.org/10.3390/pharmaceutics14081700 - 15 Aug 2022
Cited by 19 | Viewed by 3170
Abstract
In the last decade, nanomedicine has arisen as an emergent area of medicine, which studies nanometric systems, namely polymeric micelles (PMs), that increase the solubility and the stability of the encapsulated drugs. Furthermore, their application in dermal drug delivery is also relevant. PMs [...] Read more.
In the last decade, nanomedicine has arisen as an emergent area of medicine, which studies nanometric systems, namely polymeric micelles (PMs), that increase the solubility and the stability of the encapsulated drugs. Furthermore, their application in dermal drug delivery is also relevant. PMs present unique characteristics because of their unique core-shell architecture. They are colloidal dispersions of amphiphilic compounds, which self-assemble in an aqueous medium, giving a structure-type core-shell, with a hydrophobic core (that can encapsulate hydrophobic drugs), and a hydrophilic shell, which works as a stabilizing agent. These features offer PMs adequate steric protection and determine their hydrophilicity, charge, length, and surface density properties. Furthermore, due to their small size, PMs can be absorbed by the intestinal mucosa with the drug, and they transport the drug in the bloodstream until the therapeutic target. Moreover, PMs improve the pharmacokinetic profile of the encapsulated drug, present high load capacity, and are synthesized by a reproducible, easy, and low-cost method. In silico approaches have been explored to improve the physicochemical properties of PMs. Based on this, a computer-aided strategy was developed and validated to enable the delivery of poorly soluble drugs and established critical physicochemical parameters to maximize drug loading, formulation stability, and tumor exposure. Poly(2-oxazoline) (POx)-based PMs display unprecedented high loading concerning water-insoluble drugs and over 60 drugs have been incorporated in POx PMs. Among various stimuli, pH and temperature are the most widely studied for enhanced drug release at the site of action. Researchers are focusing on dual (pH and temperature) responsive PMs for controlled and improved drug release at the site of action. These dual responsive systems are mainly evaluated for cancer therapy as certain malignancies can cause a slight increase in temperature and a decrease in the extracellular pH around the tumor site. This review is a compilation of updated therapeutic applications of PMs, such as PMs that are based on Pluronics®, micelleplexes and Pox-based PMs in several biomedical applications. Full article
(This article belongs to the Special Issue Advances in Polymeric Micelles for Therapeutic Applications)
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32 pages, 8191 KiB  
Review
Progress in Polymeric Micelles for Drug Delivery Applications
by Sabna Kotta, Hibah Mubarak Aldawsari, Shaimaa M. Badr-Eldin, Anroop B. Nair and Kamal YT
Pharmaceutics 2022, 14(8), 1636; https://doi.org/10.3390/pharmaceutics14081636 - 05 Aug 2022
Cited by 46 | Viewed by 6145
Abstract
Polymeric micelles (PMs) have made significant progress in drug delivery applications. A robust core–shell structure, kinetic stability and the inherent ability to solubilize hydrophobic drugs are the highlights of PMs. This review presents the recent advances and understandings of PMs with a focus [...] Read more.
Polymeric micelles (PMs) have made significant progress in drug delivery applications. A robust core–shell structure, kinetic stability and the inherent ability to solubilize hydrophobic drugs are the highlights of PMs. This review presents the recent advances and understandings of PMs with a focus on the latest drug delivery applications. The types, methods of preparation and characterization of PMs are described along with their applications in oral, parenteral, transdermal, intranasal and other drug delivery systems. The applications of PMs for tumor-targeted delivery have been provided special attention. The safety, quality and stability of PMs in relation to drug delivery are also provided. In addition, advanced polymeric systems and special PMs are also reviewed. The in vitro and in vivo stability assessment of PMs and recent understandings in this area are provided. The patented PMs and clinical trials on PMs for drug delivery applications are considered indicators of their tremendous future applications. Overall, PMs can help overcome many unresolved issues in drug delivery. Full article
(This article belongs to the Special Issue Advances in Polymeric Micelles for Therapeutic Applications)
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