Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.9
5.4
Journals
Pharmaceutics
Special Issues
Phenolic Acids: Handy Molecules for Medicinal Purposes
share announcement

Phenolic Acids: Handy Molecules for Medicinal Purposes

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 2941

Special Issue Editors

Dr. Ana Figueiras

E-Mail Website
Guest Editor
1. Galenic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
2. LAQV-REQUIMTE, Galenic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
Interests: polymeric micelles; micelleplexes; controlled release; gene therapy; cancer; nanotechnology
Special Issues, Collections and Topics in MDPI journals
Dr. Ivana Jarak

E-Mail Website
Guest Editor
Galenic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
Interests: nanomedicine; polymer micelles; cancer therapy; gene delivery; NMR spectroscopy
Special Issues, Collections and Topics in MDPI journals
Dr. Cátia Domingues

E-Mail Website
Guest Editor
1. Galenic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
2. LAQV-REQUIMTE, Galenic and Pharmaceutical Technology Laboratory, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
3. Faculty of Medicine, Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO), University of Coimbra, 3000-548 Coimbra, Portugal
Interests: nanomedicine; polymer micelles; cancer therapy; gene delivery; micelleplexes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Phenolic acids are naturally occurring compounds that have attracted emerging interest due to their versatile properties. Indeed, phenolic acids have appeared with promising features in green chemical synthesis, medicine, pharmacy, cosmetics, and industry. More recently, their application in nanomedicine has also conquered space among the scientific and academic community. Advantageously phenolic acids are generally recognized as safe (GRAS), which is of paramount importance in the health and food sectors. Moreover, phenolic acids are promising tools for producing new formulations or drug repurposing functions considering a safety- and sustainable-by-design method centered on eco-friendly approaches. This Special Issue aims to compile the most recent advances in the application of phenolic acids from chemistry-, pharmacy-, biopharma-, and medicine-based approach, with a particular focus on their encouraging applications in new drug formulations and nanomedicine. Therefore, we cordially invite researchers to disclose original research work or review manuscripts that present up-to-date data on the use of phenolic acids for the prevention and management of human health.

Dr. Ana Figueiras
Dr. Ivana Jarak
Dr. Cátia Domingues
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • advanced therapies
  • antioxidant properties
  • cancer
  • HPLC
  • metabolomics
  • nanomedicine
  • nanoparticles
  • natural compounds
  • oxidative stress
  • phenolic acids
  • reactive oxygen species (ROS)

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

16 pages, 4035 KiB  
Article
Mechanistic Insights into the Antibiofilm Mode of Action of Ellagic Acid
by Alessandro Ratti, Enrico M. A. Fassi, Fabio Forlani, Matteo Mori, Federica Villa, Francesca Cappitelli, Jacopo Sgrignani, Gabriella Roda, Andrea Cavalli, Stefania Villa and Giovanni Grazioso
Pharmaceutics 2023, 15(6), 1757; https://doi.org/10.3390/pharmaceutics15061757 - 17 Jun 2023
Cited by 3 | Viewed by 2614
Abstract
Bacterial biofilm is a major contributor to the persistence of infection and the limited efficacy of antibiotics. Antibiofilm molecules that interfere with the biofilm lifestyle offer a valuable tool in fighting bacterial pathogens. Ellagic acid (EA) is a natural polyphenol that has shown [...] Read more.
Bacterial biofilm is a major contributor to the persistence of infection and the limited efficacy of antibiotics. Antibiofilm molecules that interfere with the biofilm lifestyle offer a valuable tool in fighting bacterial pathogens. Ellagic acid (EA) is a natural polyphenol that has shown attractive antibiofilm properties. However, its precise antibiofilm mode of action remains unknown. Experimental evidence links the NADH:quinone oxidoreductase enzyme WrbA to biofilm formation, stress response, and pathogen virulence. Moreover, WrbA has demonstrated interactions with antibiofilm molecules, suggesting its role in redox and biofilm modulation. This work aims to provide mechanistic insights into the antibiofilm mode of action of EA utilizing computational studies, biophysical measurements, enzyme inhibition studies on WrbA, and biofilm and reactive oxygen species assays exploiting a WrbA-deprived mutant strain of Escherichia coli. Our research efforts led us to propose that the antibiofilm mode of action of EA stems from its ability to perturb the bacterial redox homeostasis driven by WrbA. These findings shed new light on the antibiofilm properties of EA and could lead to the development of more effective treatments for biofilm-related infections. Full article
(This article belongs to the Special Issue Phenolic Acids: Handy Molecules for Medicinal Purposes)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop