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Advances in Anti-aging Treatment Development 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1146

Special Issue Editors

Special Issue Information

Dear Colleagues,

Inflamm-aging is the term used to refer to the chronic low-grade inflammation that develops during aging and accompanies both the development of chronic diseases (e.g., cancer, diabetes, cardiovascular disease, neurodegeneration) and functional decline in older adults. Derangements in cellular quality control systems are responsible for the accrual of intracellular “waste” (e.g., protein aggregates, damaged mitochondria, lipofuscin) and represent candidate mechanisms for the development of inflamm-aging. Indeed, many of these molecules have pro-inflammatory natures and can be released at the systemic level unless efficiently cleared. The mechanisms that regulate the displacement of these molecules are among the processes that must be tackled for the development of anti-inflammatory strategies. Additional molecular pathways that become dysregulated during aging may actively contribute to local and systemic inflammation and thus warrant investigation.

This Special Issue aims to gather contributions from researchers in the field of biogerontology and geroscience who are investigating anti-aging remedies and personalized anti-inflammatory interventions to extend one’s health- and lifespan.

We invite you to submit your latest original research or review articles to this Special Issue.

Dr. Emanuele Marzetti
Dr. Anna Picca
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • healthspan
  • lifespan
  • hallmarks of aging
  • cellular quality control
  • inflammation
  • gut microbiota
  • geroscience
  • intercellular signaling
  • geroprotective interventions
  • chronic conditions

Published Papers (1 paper)

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Research

12 pages, 1979 KiB  
Article
Cistanche deserticola Polysaccharide Reduces Inflammation and Aging Phenotypes in the Dermal Fibroblasts through the Activation of the NRF2/HO-1 Pathway
Int. J. Mol. Sci. 2023, 24(21), 15704; https://doi.org/10.3390/ijms242115704 - 28 Oct 2023
Viewed by 760
Abstract
Dermal fibroblasts maintain the skin homeostasis by interacting with the epidermis and extracellular matrix. Their senescence contributes to functional defects in the skin related to aging. Therefore, there is an urgent need for novel therapeutic agents that could inhibit fibroblast senescence. In this [...] Read more.
Dermal fibroblasts maintain the skin homeostasis by interacting with the epidermis and extracellular matrix. Their senescence contributes to functional defects in the skin related to aging. Therefore, there is an urgent need for novel therapeutic agents that could inhibit fibroblast senescence. In this study, we investigated the effects of Cistanche deserticola polysaccharide (CDP), a natural anti-inflammatory component, on the progression of senescence in human dermal fibroblasts. Normal human dermal fibroblasts (NHDFs) were cultured in passages, and highly senescent cells were selected as senescent cells. CDP treatment increased the cell proliferation in senescent NHDFs and decreased the proportion of senescence-associated-β-galactosidase-positive cells. The treatment suppressed the senescence-related secretory phenotype, and reactive oxygen species (ROS) production was reduced, alleviating H2O2-induced oxidative stress. CDP mitigated ROS formation via the nuclear factor erythroid 2-related factor/heme oxygenase-1 pathway in senescent cells and was involved in the suppression of upstream p-extracellular signal-regulated kinase. These results indicate that CDP is an antioxidant that can alleviate age-related inflammation and may be a useful compound for skin anti-aging. Full article
(This article belongs to the Special Issue Advances in Anti-aging Treatment Development 2.0)
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