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From Molecular Mechanisms to Biomarkers of Physical Frailty and Sarcopenia

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 6447

Special Issue Editors

1. Department of Medicine and Surgery, Lum Jean Monnet University, 70010 Casamassima, Italy
2. Department of Geriatrics, Neuroscience and Orthopedics, Fondazione Policlinico Universitario "A. Gemelli", IRCCS, 00168 Rome, Italy
Interests: autophagy; biogerontology; biomarkers; exosomes; inflamm-aging; metabolic markers; mitochondria; mitochondrial DNA; mitophagy; mitochondrial damage
Special Issues, Collections and Topics in MDPI journals
Fondazione Policlinico Universitario "A. Gemelli", IRCCS, 00168 Rome, Italy
Interests: geriatrics; nutrition; frailty; sarcopenia; cognitive function
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Sarcopenia, the progressive age-related loss of skeletal muscle mass and strength/function during aging, increases the risk of a vast array of adverse health outcomes, including falls, morbidity, loss of independence, disability, and mortality. Several processes and mechanisms have been indicated as contributors to age-related muscle tissue disruption. Factors spanning muscle-specific processes (e.g., mitochondrial dysfunction in skeletal myocytes) to systemic changes (e.g., inflammation and amino acid dysmetabolism) have been pinpointed as possible contributors to the pathophysiology of sarcopenia. The search for biomarkers that may allow early identification and tracking of the condition over time is very active. This Special Issue is intended to bring together basic researchers and clinicians working in sarcopenia in human and animal models to gain additional insights into the molecular mechanisms involved in the pathophysiology of sarcopenia and unveil novel biomarkers for the condition. With these premises, the ultimate aims of this Special Issue are to shed light on biological targets for interventions against sarcopenia and to identify novel biomarkers for the condition.

Dr. Anna Picca
Dr. Riccardo Calvani
Guest Editors

Manuscript Submission Information

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Keywords

  • muscle aging
  • functional impairment and frailty
  • mitochondrial dysfunction
  • cellular quality control
  • redox biology
  • inflammation
  • biomarkers
  • omics
  • gut microbiota
  • geroscience

Published Papers (1 paper)

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Research

18 pages, 4104 KiB  
Article
Lactobacillus plantarum HY7715 Ameliorates Sarcopenia by Improving Skeletal Muscle Mass and Function in Aged Balb/c Mice
Int. J. Mol. Sci. 2021, 22(18), 10023; https://doi.org/10.3390/ijms221810023 - 16 Sep 2021
Cited by 23 | Viewed by 5801
Abstract
Sarcopenia is a loss of muscle mass and function in elderly people and can lead to physical frailty and fall-related injuries. Sarcopenia is an inevitable event of the aging process that substantially impacts a person’s quality of life. Recent studies to improve muscle [...] Read more.
Sarcopenia is a loss of muscle mass and function in elderly people and can lead to physical frailty and fall-related injuries. Sarcopenia is an inevitable event of the aging process that substantially impacts a person’s quality of life. Recent studies to improve muscle function through the intake of various functional food materials are attracting attention. However, it is not yet known whether probiotics can improve muscle mass and muscle strength and affect physical performance. Lactobacillus plantarum HY7715 (HY7715) is a lactic acid bacteria isolated from kimchi. The present research shows that L. plantarum HY7715 increases physical performance and skeletal muscle mass in 80-week-old aged Balb/c male mice. HY7715 not only induces myoblast differentiation and mitochondrial biogenesis but also inhibits the sarcopenic process in skeletal muscle. In addition, HY7715 recovers the microbiome composition and beta-diversity shift. Therefore, HY7715 has promise as a functional probiotic supplement to improve the degeneration of muscle function that is associated with aging. Full article
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