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Dietary Phytochemicals as a Promising Nutritional Strategy for Sarcopenia

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 6357

Special Issue Editors

Special Issue Information

Dear Colleagues,

Sarcopenia, the progressive decline of skeletal muscle mass and strength/function observed during aging, increases the risk of negative health outcomes (e.g., falls, morbidity, loss of independence, disability, and mortality).

Lifestyle habits have an impact on the rate of muscle loss with a large body of evidence indicating a positive effect of adapted nutrition and physical activity. The promotion of a healthy diet is indeed among the most successful strategies to counteract sarcopenia. However, studies investigating the contribution of micro- and macronutrients on muscle metabolism in old age as well as that of dietary supplements and natural bioactive compounds are sparse.

This Special Issue is intended to gather contributions from basic and clinical researchers working in the field of sarcopenia to gain insights on nutritional strategies that may be harnessed to delay and/or counteract age-related muscle loss.

We therefore invite you to submit your latest original research or review articles to this Special Issue.

Dr. Emanuele Marzetti
Dr. Anna Picca
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • biological aging
  • biomarkers
  • inflammation
  • metabolomics
  • mitochondria
  • muscle wasting
  • physical performance
  • senescence

Published Papers (2 papers)

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Research

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17 pages, 3592 KiB  
Article
The Inhibition of Autophagy and Pyroptosis by an Ethanol Extract of Nelumbo nucifera Leaf Contributes to the Amelioration of Dexamethasone-Induced Muscle Atrophy
by Eunji Park, Hojung Choi, Cao-Sang Truong and Hee-Sook Jun
Nutrients 2023, 15(4), 804; https://doi.org/10.3390/nu15040804 - 04 Feb 2023
Cited by 4 | Viewed by 2606
Abstract
Muscle atrophy is characterized by a decline in muscle mass and function. Excessive glucocorticoids in the body due to aging or drug treatment can promote muscle wasting. In this study, we investigated the preventive effect of Nelumbo nucifera leaf (NNL) ethanolic extract on [...] Read more.
Muscle atrophy is characterized by a decline in muscle mass and function. Excessive glucocorticoids in the body due to aging or drug treatment can promote muscle wasting. In this study, we investigated the preventive effect of Nelumbo nucifera leaf (NNL) ethanolic extract on muscle atrophy induced by dexamethasone (DEX), a synthetic glucocorticoid, in mice and its underlying mechanisms. The administration of NNL extract increased weight, cross-sectional area, and grip strength of quadriceps (QD) and gastrocnemius (GA) muscles in DEX-induced muscle atrophy in mice. The NNL extract administration decreased the expression of muscle atrophic factors, such as muscle RING-finger protein-1 and atrogin-1, and autophagy factors, such as Beclin-1, microtubule-associated protein 1A/1B-light chain 3 (LC3-I/II), and sequestosome 1 (p62/SQSTM1) in DEX-injected mice. DEX injection increased the protein expression levels of NOD-like receptor pyrin domain-containing protein 3 (NLRP3), cleaved-caspase-1, interleukin-1beta (IL-1β), and cleaved-gasdermin D (GSDMD), which were significantly reduced by NNL extract administration (500 mg/kg/day). In vitro studies using C2C12 myotubes also revealed that NNL extract treatment inhibited the DEX-induced increase in autophagy factors, pyroptosis-related factors, and NF-κB. Overall, the NNL extract prevented DEX-induced muscle atrophy by downregulating the ubiquitin–proteasome system, autophagy pathway, and GSDMD-mediated pyroptosis pathway, which are involved in muscle degradation. Full article
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Review

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30 pages, 782 KiB  
Review
Accounting Gut Microbiota as the Mediator of Beneficial Effects of Dietary (Poly)phenols on Skeletal Muscle in Aging
by Andrea Ticinesi, Antonio Nouvenne, Nicoletta Cerundolo, Alberto Parise and Tiziana Meschi
Nutrients 2023, 15(10), 2367; https://doi.org/10.3390/nu15102367 - 18 May 2023
Cited by 4 | Viewed by 3371
Abstract
Sarcopenia, the age-related loss of muscle mass and function increasing the risk of disability and adverse outcomes in older people, is substantially influenced by dietary habits. Several studies from animal models of aging and muscle wasting indicate that the intake of specific polyphenol [...] Read more.
Sarcopenia, the age-related loss of muscle mass and function increasing the risk of disability and adverse outcomes in older people, is substantially influenced by dietary habits. Several studies from animal models of aging and muscle wasting indicate that the intake of specific polyphenol compounds can be associated with myoprotective effects, and improvements in muscle strength and performance. Such findings have also been confirmed in a smaller number of human studies. However, in the gut lumen, dietary polyphenols undergo extensive biotransformation by gut microbiota into a wide range of bioactive compounds, which substantially contribute to bioactivity on skeletal muscle. Thus, the beneficial effects of polyphenols may consistently vary across individuals, depending on the composition and metabolic functionality of gut bacterial communities. The understanding of such variability has recently been improved. For example, resveratrol and urolithin interaction with the microbiota can produce different biological effects according to the microbiota metabotype. In older individuals, the gut microbiota is frequently characterized by dysbiosis, overrepresentation of opportunistic pathogens, and increased inter-individual variability, which may contribute to increasing the variability of biological actions of phenolic compounds at the skeletal muscle level. These interactions should be taken into great consideration for designing effective nutritional strategies to counteract sarcopenia. Full article
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