mTOR Signaling in Metabolism and Cancer
Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 58871
A printed edition of this Special Issue is available here.
Interests: mTOR; cell signaling; cell motility; natural products; cadmium
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The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, integrates environmental cues (hormones, growth factors, nutrients, oxygen, and energy), regulating cell growth, proliferation, survival and motility as well as metabolism. Evidence has demonstrated that deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. Current knowledge indicates that mTOR functions as two distinct multiprotein complexes, mTORC1 and mTORC2. mTORC1 regulates the phosphorylation of p70 S6 kinase (S6K1), eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), lipin1, etc., and controls the synthesis of proteins, lipids and nucleotides related to cell growth and proliferation, while mTORC2 regulates the phosphorylation of Akt, serum/glucocorticoid regulated kinase (SGK), protein kinase C (PKC), etc., and controls actin cytoskeleton and cell survival. These findings not only reveal the crucial role of mTOR in physiology and pathology, but also reflect the complexity of the mTOR signaling network.
This Special Issue aims to summarize the current understanding of the mTOR pathway and its role in the process of metabolism and cancer.
We look forward to your contributions.
Prof. Shile Huang
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