Special Issue "mTOR Signaling in Metabolism and Cancer 2.0"

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Proliferation and Division".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 237

Special Issue Editors

Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, USA
Interests: mTOR; cell signaling; cell motility; natural products; cadmium
Special Issues, Collections and Topics in MDPI journals
School of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, China
Interests: cancer research; molecular biology; oncology; toxicology

Special Issue Information

Dear Colleagues,

This is the expanded second edition of mTOR Signaling in Metabolism and Cancer that 1st edition resulted in the publishing of 10 papers and one Reprint Book.

The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, integrates environmental cues (hormones, growth factors, nutrients, oxygen, and energy) regulating cell growth, proliferation, survival, and motility, as well as metabolism. Deregulated mTOR signaling has been implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. Current knowledge indicates that mTOR functions as two distinct multiprotein complexes, mTORC1 and mTORC2. mTORC1 regulates the phosphorylation of the p70 S6 kinase (S6K1), eukaryotic initiation factor 4E (eIF4E), binding protein 1 (4E-BP1), lipin1, etc., and controls the synthesis of proteins, lipids, and nucleotides related to cell growth and proliferation, while mTORC2 regulates the phosphorylation of Akt, serum/glucocorticoid-regulated kinase (SGK), protein kinase C (PKC), etc., and controls actin cytoskeleton and cell survival. These findings not only reveal the crucial role of mTOR in physiology and pathology, but also reflect the complexity of the mTOR signaling network.

This Special Issue aims to summarize the current understanding of the mTOR pathway and its role in metabolism and cancer.

We look forward to receiving your contributions.

Prof. Dr. Shile Huang
Prof. Dr. Wenxing Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mTOR
  • metabolism
  • cancer
  • Akt

Related Special Issue

Published Papers

This special issue is now open for submission.
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