Special Issue "mTOR Signaling in Metabolism and Cancer 2.0"
Deadline for manuscript submissions: 31 December 2024 | Viewed by 237
Interests: mTOR; cell signaling; cell motility; natural products; cadmium
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Special Issue in Cells: PI3K/AKT/mTOR Signaling Network in Human Health and Diseases
Special Issue in Cells: PI3K/AKT/mTOR Signaling Network in Human Health and Diseases 2.0
The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, integrates environmental cues (hormones, growth factors, nutrients, oxygen, and energy) regulating cell growth, proliferation, survival, and motility, as well as metabolism. Deregulated mTOR signaling has been implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. Current knowledge indicates that mTOR functions as two distinct multiprotein complexes, mTORC1 and mTORC2. mTORC1 regulates the phosphorylation of the p70 S6 kinase (S6K1), eukaryotic initiation factor 4E (eIF4E), binding protein 1 (4E-BP1), lipin1, etc., and controls the synthesis of proteins, lipids, and nucleotides related to cell growth and proliferation, while mTORC2 regulates the phosphorylation of Akt, serum/glucocorticoid-regulated kinase (SGK), protein kinase C (PKC), etc., and controls actin cytoskeleton and cell survival. These findings not only reveal the crucial role of mTOR in physiology and pathology, but also reflect the complexity of the mTOR signaling network.
This Special Issue aims to summarize the current understanding of the mTOR pathway and its role in metabolism and cancer.
We look forward to receiving your contributions.
Prof. Dr. Shile Huang
Prof. Dr. Wenxing Chen
Manuscript Submission Information
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