Special Issue "Advances in Neurogenesis—Series II"
Deadline for manuscript submissions: 30 November 2023 | Viewed by 13176
Interests: neurogenesis; gliogenesis; epigenetics; transcription factors; depression; neural circuits
Special Issues, Collections and Topics in MDPI journals
The adult brain displays different forms of neural plasticity, ranging from neuronal synapto-dendritic rearrangements to the generation of novel neuronal and glial cells from neural stem cells (NSCs), processes known as adult neuro- and gliogenesis, respectively.
Postnatal neuro- and glioplasticity are largely driven by the transduction of environmental stimuli into essential neuroadaptations. Neuro- and glioplastic maladaptations often result in the manifestation of pathological traits, from which depressive behavior is a paradigmatic example.
Though increasing evidence supports the role of the hippocampal cytogenesis in brain physiology, its precise function is still debatable. The heterogeneity of the experimental models, timeframes, and methodological approaches used to address this subject has yielded conflicting results regarding the impact of the newborn cells on behavior. Still, converging data reveal a role for adult hippocampal cytogenesis in long-term spatial memory, cognitive flexibility, pattern separation, and clearance of hippocampal memories. Given the involvement of adult neurogenesis in such complex behaviors, it has become plausible to anticipate that its disruption could impact the neuronal circuitry and, ultimately, be implicated in the development of psychiatric and neurodegenerative disorders.
Understanding the role of novel genes and cytogenic regulators and better dissecting their impact throughout developmental periods and at different behavioral domains is of paramount importance to increase our current comprehension of this topic.
Dr. Luisa Alexandra Meireles Pinto
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- cell plasticity
- neural circuits
- cytogenic regulators
- neuropsychiatric disorders
- neurodegenerative disorders
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Microglia and tripartite synapse in neurodevelopmental disorders
Authors: Laura Ferrucci1,3 , Federica Cordella1,3 , Cristiana Centofanti2, Iva Cantando2, Silvia Di Angelantonio1, Davide Ragozzino1 and Paola Bezzi 1,2
Affiliation: 1. Depart of Physiology and Pharmacology, University of Rome Sapienza, Rome, Italy 2. DNF, University of Lausanne, Lausanne, Italy 3. Equal contribution
Abstract: Synapses are fundamental structures of neural circuits that control brain functions and behavioral and cognitive processes. Synapses undergo formation, maturation and elimination mainly during postnatal development via a complex interplay with neighboring glial cells that , by shaping neural connectivity may have a crucial role in strengthening and weakening of synaptic functions, that is, functional plasticity of synapses. Indeed, an increasing number of studies have unveiled the roles of microglia and astrocytes in synapse formation, maturation and elimination as well as in regulating synaptic function. Over the past 15 years, the mechanisms underlying microglia- and astrocytes-dependent regulation of synaptic plasticity have been thoroughly studied, and researchers have reported that the disruption of glial cells in early postnatal development may underlie the cause of synaptic dysfunction that leads to neurodevelopmental disorders.