Frontiers in Chondrocyte Biology
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Tissues and Organs".
Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 7407
Special Issue Editor
Special Issue Information
Dear Colleagues,
The chondrocyte, a mesenchymal progenitor derivative, is the sole cell type found in vertebrate hyaline growth plates and articular cartilage tissues. It is responsible for the development and maintenance of the cartilage extracellular matrix, and responds to both molecular and mechanical cues. Depending on the cues received, the chondrocyte may proliferate, exit the cell cycle, differentiate into a hypertrophic state, or undergo cell death. Recent evidence also suggests that during development, the chondrocyte can transdifferentiate into a bone-forming osteoblast. These phenotypic changes by the chondrocyte govern endochondral bone formation during development as well as during fracture repair. While adult articular chondrocytes residing in the unmineralized articular cartilage are a mostly quiescent cell population, evidence suggests they can re-enter the cell cycle and undergo hypertrophy during the pathogenesis of osteoarthritis, likely contributing to degeneration of their matrix. The underlying mechanisms governing the chondrocyte phenotype involve signaling events that regulate gene expression as well as cellular processes such as metabolism, mitochondrial function, ER integrity, and autophagy, among others. In this Special Issue entitled, “Frontiers in Chondrocyte Biology,” we invite submissions on the molecular and biomechanical regulation of the chondrocyte phenotype during development, bone repair, cartilage homeostasis, and joint pathogenesis.
Dr. Jennifer H. Jonason
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- chondrocyte
- cartilage
- growth plate
- fracture repair
- osteoarthritis
- tissue homeostasis
- aging
- differentiation
- hypertrophy
- proliferation
- apoptosis
- autophagy
- signal transduction
- metabolism
- mitochondria
