Senescent Cells: A Key to Understanding Aging and Age-Related Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1486
Special Issue Editor
Interests: endothelial dysfunction; macrophage–endothelial interaction; miRNAs; lipid rafts
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Modern societies are undergoing a notable demographic change driven by rising life expectancy, which has led to a larger population of seniors and older individuals. Aging is an ongoing process that happens at the cellular, organ, and organism levels over time, spanning the entire adult lifespan. It is important to note that the terms aging and cellular senescence cannot be used interchangeably. Aging denotes gradual deterioration over time, while senescence occurs throughout the entire lifespan, including during embryonic development. Although the number of senescent cells generally increases with age, senescence contributes significantly to growth and wound healing. Senescent cells undergo metabolic and morphological changes, chromatin reorganization, altered gene expression, and have a pro-inflammatory phenotype known as the senescence-associated secretory phenotype (SASP). Understanding the molecular and cellular mechanisms of aging is crucial, particularly from a biomedical perspective focused on healthy aging. This discussion explores how aging affects different organs and tissues and offers insights into interventions that can modify the aging process, thereby postponing disease onset and increasing the time spent in good health, known as healthspan, rather than just lifespan. This Special Issue is intended for experts in the field who aim to explore the fundamental scientific discoveries related to aging, longevity, and the molecular mechanisms involved in aging.
Prof. Dr. Julia Schumann
Guest Editor
Manuscript Submission Information
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Keywords
- molecular genetics of ageing
- biomarkers of cellular senescence
- SASP
- metabolism in old age
- the role of mitochondria in the aging process
- inflammaging
- the aging brain
- age-related diseases
- diagnostic and therapeutic strategies targeting senescence in the clinic
