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Membranes
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Molecular Mechanism of Cellular Membranes for Signal Transduction, Volume II
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Molecular Mechanism of Cellular Membranes for Signal Transduction, Volume II

A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Biological Membrane Functions".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 4924

Special Issue Editor

Prof. Dr. Julia Schumann

E-Mail Website
Guest Editor
Clinic for Anesthesiology and Surgical Intensive Care, University Hospital Halle (Saale), 06120 Halle, Germany
Interests: endothelial dysfunction; macrophage–endothelial interaction; miRNAs; lipid rafts
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cellular membranes are indispensable to life and play a pivotal role in cell functionality. An essential task of the membrane is ensuring cellular communication processes. It is well known that the plasma membrane is composed of dynamic membrane patches, which differ in their assembly and biological activity. Formation of these microdomains, also referred to as lipid rafts, is thought to be due to unequal affinities between various lipid species. The domains have been shown to attract distinct proteins, thereby promoting particular biochemical processes. In doing so, the activity of cellular enzymes, transcription factors, and post-transcriptional regulation factors (such as miRNAs) can be directly modulated. It can thus be assumed that membrane microdomain structure influences cellular signal transduction, and vice versa.

This Special Issue aims to cover the latest findings regarding membrane molecular assembly, signal transduction processes affecting membrane composition, as well as the ways membranes impact signaling cascades. Both original papers and reviews are welcome. Potential topics include but are not limited to the following:

  • Membrane (microdomain) architecture;
  • Mediators affecting membrane composition;
  • Assembly, localization, and interaction of membrane receptors;
  • Role of membrane microdomains for the initiation of signaling cascades;
  • Signal transduction processes influencing membrane functionality;
  • Impact of membrane-mediated signaling processes on post-transcriptional gene expression regulation.

Prof. Dr. Julia Schumann
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Membranes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • membrane build-up
  • lipid rafts
  • membrane receptors
  • signaling cascades
  • transcriptional and post-transcriptional gene expression regulation

Published Papers (2 papers)

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Research

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21 pages, 10772 KiB  
Article
Natural Killer Cell Derived Microvesicles Affect the Function of Trophoblast Cells
by Dmitry Sokolov, Alina Gorshkova, Kseniia Markova, Yulia Milyutina, Kseniya Pyatygina, Maria Zementova, Andrey Korenevsky, Valentina Mikhailova and Sergey Selkov
Membranes 2023, 13(2), 213; https://doi.org/10.3390/membranes13020213 - 09 Feb 2023
Cited by 1 | Viewed by 2177
Abstract
The interaction of natural killer (NK) and trophoblast cells underlies the formation of immune tolerance in the mother–fetus system and the maintenance of the physiological course of pregnancy. In addition, NK cells affect the function of trophoblast cells, interacting with them via the [...] Read more.
The interaction of natural killer (NK) and trophoblast cells underlies the formation of immune tolerance in the mother–fetus system and the maintenance of the physiological course of pregnancy. In addition, NK cells affect the function of trophoblast cells, interacting with them via the receptor apparatus and through the production of cytokines. Microvesicles (MVs) derived from NK cells are able to change the function of target cells. However, in the overall pattern of interactions between NK cells and trophoblasts, the possibility that both can transmit signals to each other via MVs has not been taken into account. Therefore, the aim of this study was to assess the effect of NK cell-derived MVs on the phenotype, proliferation, and migration of trophoblast cells and their expression of intracellular messengers. We carried out assays for the detection of content transferred from MV to trophoblasts. We found that NK cell-derived MVs did not affect the expression of CD54, CD105, CD126, CD130, CD181, CD119, and CD120a receptors in trophoblast cells or lead to the appearance of CD45 and CD56 receptors in the trophoblast membrane. Further, the MVs reduced the proliferation but increased the migration of trophoblasts with no changes to their viability. Incubation of trophoblast cells in the presence of MVs resulted in the activation of STAT3 via pSTAT3(Ser727) but not via pSTAT3(Tyr705). The treatment of trophoblasts with MVs did not result in the phosphorylation of STAT1 and ERK1/2. The obtained data indicate that NK cell-derived MVs influence the function of trophoblast cells, which is accompanied by the activation of STAT3 signaling. Full article
(This article belongs to the Special Issue Molecular Mechanism of Cellular Membranes for Signal Transduction, Volume II)
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Review

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15 pages, 685 KiB  
Review
Membrane Progesterone Receptors (mPRs/PAQRs) Are Going beyond Its Initial Definitions
by Justin Aickareth, Majd Hawwar, Nickolas Sanchez, Revathi Gnanasekaran and Jun Zhang
Membranes 2023, 13(3), 260; https://doi.org/10.3390/membranes13030260 - 22 Feb 2023
Cited by 4 | Viewed by 2228
Abstract
Progesterone (PRG) is a key cyclical reproductive hormone that has a significant impact on female organs in vertebrates. It is mainly produced by the corpus luteum of the ovaries, but can also be generated from other sources such as the adrenal cortex, Leydig [...] Read more.
Progesterone (PRG) is a key cyclical reproductive hormone that has a significant impact on female organs in vertebrates. It is mainly produced by the corpus luteum of the ovaries, but can also be generated from other sources such as the adrenal cortex, Leydig cells of the testes and neuronal and glial cells. PRG has wide-ranging physiological effects, including impacts on metabolic systems, central nervous systems and reproductive systems in both genders. It was first purified as an ovarian steroid with hormonal function for pregnancy, and is known to play a role in pro-gestational proliferation during pregnancy. The main function of PRG is exerted through its binding to progesterone receptors (nPRs, mPRs/PAQRs) to evoke cellular responses through genomic or non-genomic signaling cascades. Most of the existing research on PRG focuses on classic PRG-nPR-paired actions such as nuclear transcriptional factors, but new evidence suggests that PRG also exerts a wide range of PRG actions through non-classic membrane PRG receptors, which can be divided into two sub-classes: mPRs/PAQRs and PGRMCs. The review will concentrate on recently found non-classical membrane progesterone receptors (mainly mPRs/PAQRs) and speculate their connections, utilizing the present comprehension of progesterone receptors. Full article
(This article belongs to the Special Issue Molecular Mechanism of Cellular Membranes for Signal Transduction, Volume II)
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