Membranes

Open AccessFeature PaperEditor’s ChoiceArticle

Open Pore Ultrafiltration Hollow Fiber Membrane Fabrication Method via Dual Pore Former with Dual Dope Solution Phase

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Membranes 2022, 12(11), 1140; https://doi.org/10.3390/membranes12111140 - 13 Nov 2022

Viewed by 1059

Abstract

Hollow-fiber membranes are widely used in various fields of membrane processes because of their numerous properties, e.g., large surface area, high packing density, mass production with uniform quality, obvious end-of-life indicators, and so on. However, it is difficult to control the pores and [...] Read more.

Hollow-fiber membranes are widely used in various fields of membrane processes because of their numerous properties, e.g., large surface area, high packing density, mass production with uniform quality, obvious end-of-life indicators, and so on. However, it is difficult to control the pores and internal properties of hollow-fiber membranes due to their inherent structure: a hollow inside surrounded by a wall membrane. Herein, we aimed to control pores and the internal structure of hollow-fiber membranes by fabricating a dual layer using a dual nozzle. Two different pore formers, polyethylene glycol (PEG) and polyvinyl pyrrolidone (PVP), were separately prepared in the dope solutions and used for spinning the dual layer. Our results show that nanoscale pores could be formed on the lumen side (26.8–33.2 nm), and the open pores continuously increased in size toward the shell side. Due to robust pore structure, our fabricated membrane exhibited a remarkable water permeability of 296.2 ± 5.7 L/m²·h·bar and an extremely low BSA loss rate of 0.06 ± 0.02%, i.e., a high BSA retention of 99.94%. In consideration of these properties, the studied membranes are well-suited for use in either water treatment or hemodialysis. Overall, our membranes could be considered for the latter application with a high urea clearance of 257.6 mL/min, which is comparable with commercial membranes. Full article

(This article belongs to the Special Issue Separation Principles and Applications of Membrane Technology)

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Open AccessFeature PaperEditor’s ChoiceArticle

Bioselective PES Membranes Based on Chitosan Functionalization and Virus-Imprinted NanoMIPs for Highly Efficient Separation of Human Pathogenic Viruses from Water

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Carmen Andreina Olivares Moreno

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Zeynep Altintas

Membranes 2022, 12(11), 1117; https://doi.org/10.3390/membranes12111117 - 09 Nov 2022

Cited by 2 | Viewed by 1050

Abstract

Waterborne viruses are a public health concern due to relatively small infection doses. Particularly, adenoviruses (AdVs) are more resistant than RNA viruses to water purification treatments in terms of ultraviolet (UV) irradiation, pH, and chlorination tolerance. Moreover, AdVs are one of the most [...] Read more.

Waterborne viruses are a public health concern due to relatively small infection doses. Particularly, adenoviruses (AdVs) are more resistant than RNA viruses to water purification treatments in terms of ultraviolet (UV) irradiation, pH, and chlorination tolerance. Moreover, AdVs are one of the most predominant waterborne viruses. Membrane separations have proven superior removal capabilities of waterborne pathogens over other separation methods. However, virus removal at ultratrace levels is still a significant challenge for current membrane technology. This study successfully addressed this challenge by developing a bioselective polyethersulfone (PES) membrane by a joint strategy involving chitosan hydrophilic surface modification and the immobilization of adenovirus-specific molecularly imprinted nanoparticles (nanoMIPs). The topological and chemical changes taking place on the membrane surface were characterized by using atomic force microscopy (AFM) and scanning electron microscopy (SEM). Furthermore, hydrophilicity and membrane performance were investigated in terms of swelling behavior, permeation flux, and surface fouling studies. The membrane efficacy was evaluated by filtration experiments, where the virus concentration of the loading solution before filtration and the permeates after filtration was quantified. The novel bioselective membrane showed excellent virus removal capabilities by separating 99.99% of the viruses from the water samples. Full article

(This article belongs to the Special Issue Advances in Molecularly Imprinted Membranes)

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Open AccessFeature PaperEditor’s ChoiceArticle

Exploring Membrane Binding Targets of Disordered Human Tau Aggregates on Lipid Rafts Using Multiscale Molecular Dynamics Simulations

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Membranes 2022, 12(11), 1098; https://doi.org/10.3390/membranes12111098 - 04 Nov 2022

Cited by 2 | Viewed by 1093

Abstract

The self-aggregation of tau, a microtubule-binding protein, has been linked to the onset of Alzheimer’s Disease. Recent studies indicate that the disordered tau aggregates, or oligomers, are more toxic than the ordered fibrils found in the intracellular neurofibrillary tangles of tau. At present, [...] Read more.

The self-aggregation of tau, a microtubule-binding protein, has been linked to the onset of Alzheimer’s Disease. Recent studies indicate that the disordered tau aggregates, or oligomers, are more toxic than the ordered fibrils found in the intracellular neurofibrillary tangles of tau. At present, details of tau oligomer interactions with lipid rafts, a model of neuronal membranes, are not known. Using molecular dynamics simulations, the lipid-binding events, membrane-damage, and protein folding of tau oligomers on various lipid raft surfaces were investigated. Tau oligomers preferred to bind to the boundary domains (Lod) created by the coexisting liquid-ordered (Lo) and liquid-disordered (Ld) domains in the lipid rafts. Additionally, stronger binding of tau oligomers to the ganglioside (GM1) and phosphatidylserine (PS) domains, and subsequent protein-induced lipid chain order disruption and beta-sheet formation were detected. Our results suggest that GM1 and PS domains, located exclusively in the outer and inner leaflets, respectively, of the neuronal membranes, are specific membrane domain targets, whereas the Lod domains are non-specific targets, of tau oligomers binding to neurons. The molecular details of these specific and non-specific tau bindings to lipid rafts may provide new insights into understanding membrane-associated tauopathies leading to Alzheimer’s Disease. Full article

(This article belongs to the Special Issue Lipid Membranes and Their Applications)

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Open AccessFeature PaperEditor’s ChoiceArticle

Obtaining and Characterizing the Osmium Nanoparticles/n–Decanol Bulk Membrane Used for the p–Nitrophenol Reduction and Separation System

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Aurelia Cristina Nechifor

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Alexandru Goran

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Szidonia-Katalin Tanczos

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Florentina Mihaela Păncescu

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Ovidiu-Cristian Oprea

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Alexandra Raluca Grosu

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Membranes 2022, 12(10), 1024; https://doi.org/10.3390/membranes12101024 - 21 Oct 2022

Cited by 3 | Viewed by 877

Abstract

Liquid membranes based on nanoparticles follow a continuous development, both from obtaining methods and characterization of techniques points of view. Lately, osmium nanoparticles have been deposited either on flat membranes, with the aim of initiating some reaction processes, or on hollow fiber membranes, [...] Read more.

Liquid membranes based on nanoparticles follow a continuous development, both from obtaining methods and characterization of techniques points of view. Lately, osmium nanoparticles have been deposited either on flat membranes, with the aim of initiating some reaction processes, or on hollow fiber membranes, with the aim of increasing the contact surface with the phases of the membrane system. This paper presents the obtainment and characterization of a liquid membrane based on osmium nanoparticles (Os–NP) dispersed in ndecanol (nDol) for the realization of a membrane system with a large contact surface between the phases, but without using a liquid membrane support. The dispersion of osmium nanoparticles in n-decanol is carried out by the method of reducing osmium tetroxide with 1–undecenoic acid (UDA). The resulting membrane was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive spectroscopy analysis (EDAX), thermoanalysis (TG, DSC), Fourier transform infra-red (FTIR) spectroscopy and dynamic light scattering (DLS). In order to increase the mass transfer surface, a design for the membrane system was realized with the dispersion of the membrane through the receiving phase and the dispersion of the source phase through the membrane (DBLM-dispersion bulk liquid membrane). The process performance was tested for the reduction of p–nitrophenol (pNP) from the source phase, using sodium tetra-borohydride (NaBH₄), to p–aminophenol (pAP), which was transported and collected in the receiving phase. The obtained results show that membranes based on the dispersion of osmium nanoparticles in n–decanol can be used with an efficiency of over 90% for the reduction of p–nitrophenol and the separation of p–aminophenol. Full article

(This article belongs to the Special Issue A Commemorative Issue in Honor of Docent Constantin Luca: pH in Membrane Processes)

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Open AccessFeature PaperEditor’s ChoiceArticle

Thermally Rearranged Mixed Matrix Membranes from Copoly(o-hydroxyamide)s and Copoly(o-hydroxyamide-amide)s with a Porous Polymer Network as a Filler—A Comparison of Their Gas Separation Performances

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Cenit Soto

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Bibiana Comesaña-Gandara

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Ángel Marcos

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Membranes 2022, 12(10), 998; https://doi.org/10.3390/membranes12100998 - 14 Oct 2022

Cited by 1 | Viewed by 1046

Abstract

Copoly(o-hydroxyamide)s (HPA) and copoly(o-hydroxyamide-amide)s (PAA) have been synthesized to be used as continuous phases in mixed matrix membranes (MMMs). These polymeric matrices were blended with different loads (15 and 30 wt.%) of a relatively highly microporous porous polymer network (PPN). SEM images of [...] Read more.

Copoly(o-hydroxyamide)s (HPA) and copoly(o-hydroxyamide-amide)s (PAA) have been synthesized to be used as continuous phases in mixed matrix membranes (MMMs). These polymeric matrices were blended with different loads (15 and 30 wt.%) of a relatively highly microporous porous polymer network (PPN). SEM images of the manufactured MMMs exhibited good compatibility between the two phases for all the membranes studied, and their mechanical properties have been shown to be good enough even after thermal treatment. The WAX results show that the addition of PPN as a filler up to 30% does not substantially change the intersegmental distance and the polymer packing. It seems that, for all the membranes studied, the free volume that determines gas transport is in the high end of the possible range. This means that gas flow occurs mainly between the microvoids in the polymer matrix around the filler. In general, both HPA- and PAA-based MMMs exhibited a notable improvement in gas permeability, due to the presence of PPN, for all gases tested, with an almost constant selectivity. In summary, although the thermal stability of the PAA is limited by the thermal stability of the polyamide side chain, their mechanical properties were better. The permeability was higher for the PAA membranes before their thermal rearrangement, and these values increased after the addition of moderate amounts of PPN. Full article

(This article belongs to the Special Issue Advanced Membrane-based Technologies: Fabrication, Characterization, and Applications)

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Open AccessFeature PaperEditor’s ChoiceArticle

Membrane Emulsification—A Novel Solution for Treatment and Reuse of Produced Water from Oil Field

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Aamer Ali

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Usman Taqui Syed

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Thomas Skovfoged Bak

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Cejna Anna Quist-Jensen

Membranes 2022, 12(10), 971; https://doi.org/10.3390/membranes12100971 - 02 Oct 2022

Viewed by 1617

Abstract

Produced water (PW) is, by volume, the largest waste product of the oil- and gas-exploration industry and contains pollutants such as hydrocarbons and heavy metals. To meet the stringent environmental regulations, PW must be treated before discharging into the environment. The current study [...] Read more.

Produced water (PW) is, by volume, the largest waste product of the oil- and gas-exploration industry and contains pollutants such as hydrocarbons and heavy metals. To meet the stringent environmental regulations, PW must be treated before discharging into the environment. The current study proposes a novel treatment method where PW is used to prepare oil-in-water emulsion with potential applications within the oil-exploration industry. The emulsions are prepared by applying hollow fiber membrane emulsification (ME) on PW, which inherently contains oil, as to-be-dispersed phase. The results demonstrate that the average droplet size of the emulsions is a function of pressure applied on to-be-dispersed phase and could be customized from 0.24 to 0.65 µm by varying the pressure from 0.25 to 1 bar, respectively. Stability of the emulsions was verified under high pressure and a temperature and storage period of more than 24 h. The calculations showed that an ME unit with <100 kg weight and <1 m³ volume is appropriate to transform the daily average volume of PW from the Danish part of the North Sea into the emulsions. The study provides a novel route, which also complies well with the requirements (low-weight and small spatial footprints) of the offshore oil rigs, to treat and reuse PW within the oil production process and, therefore, eliminates its environmental footprint. Full article

(This article belongs to the Special Issue Membrane Science towards Sustainable Development Goals (SDGs))

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Open AccessFeature PaperEditor’s ChoiceArticle

Cross-Linked Polyimide/ZIF-8 Mixed-Matrix Membranes by In Situ Formation of ZIF-8: Effect of Cross-Linking on Their Propylene/Propane Separation

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Sunghwan Park

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Hae-Kwon Jeong

Membranes 2022, 12(10), 964; https://doi.org/10.3390/membranes12100964 - 01 Oct 2022

Cited by 1 | Viewed by 1260

Abstract

Despite their potential for the scalable production of mixed-matrix membranes (MMMs), the MMMs prepared by the polymer-modification-enabled in situ metal–organic framework formation (PMMOF) process showed a considerable reduction in gas permeability as the filler loading increased. It was hypothesized that a correlation existed [...] Read more.

Despite their potential for the scalable production of mixed-matrix membranes (MMMs), the MMMs prepared by the polymer-modification-enabled in situ metal–organic framework formation (PMMOF) process showed a considerable reduction in gas permeability as the filler loading increased. It was hypothesized that a correlation existed between the decrease in permeability and the change in the properties of the polymer, such as free volume and chain flexibility, upon in situ MOF formation. Herein, we aim to address the permeability reduction by using a cross-linked polyimide (6FDA-DAM:DABA (3:2)). It was found the degree of cross-linking affected not only the properties of the polymer, but also the in situ formation of the ZIF-8 filler particles in the cross-linked polymer. The proper degree of cross-linking resulted in suppressing C₃H₆ permeability reduction, suggesting a possible strategy to overcome the issue of PMMOF. The swelling of the polymer followed by chain rearrangement during the PMMOF, as well as the structural rigidity of the polymer, were found to be critical in mitigating permeability reduction. Full article

(This article belongs to the Special Issue Enhancing Separation Performance of Mixed Matrix Membranes)

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Open AccessFeature PaperEditor’s ChoiceArticle

Energy and Nutrients from Apple Waste Using Anaerobic Digestion and Membrane Technology

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Isabel González-García

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Berta Riaño

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Beatriz Molinuevo-Salces

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María Cruz García-González

Membranes 2022, 12(9), 897; https://doi.org/10.3390/membranes12090897 - 17 Sep 2022

Viewed by 1070

Abstract

The worldwide increment of food waste requires innovative management solutions, aligned with sustainability, energy, and food security. Anaerobic digestion (AD), followed by nutrient recovery, may be considered an interesting approach. This study proposed a co-digestion of apple pomace (AP) with swine manure (SM) [...] Read more.

The worldwide increment of food waste requires innovative management solutions, aligned with sustainability, energy, and food security. Anaerobic digestion (AD), followed by nutrient recovery, may be considered an interesting approach. This study proposed a co-digestion of apple pomace (AP) with swine manure (SM) to study the effect of different proportions of AP (0, 7.5, 15, and 30%, on a volatile solids (VS) basis) on the methane production and the stability of the process. Subsequently, the gas-permeable membrane (GPM) technology was applied to recover nitrogen (N) as ammonium sulfate (bio-based fertilizer) from the digestates produced after the AD of 7.5% of AP and SM, and SM alone. The results showed that the co-digestion of 7.5% and 15% of AP with SM presented a methane production similar to the AD of SM alone (with 412.3 ± 62.6, 381.8 ± 134.1, and 421.7 ± 153.6 mL g VS⁻¹ day⁻¹, respectively). The later application of the GPM technology on the resulting digestates, with SM alone and with 7.5% of AP with SM, showed total ammoniacal N recovery rates of 33 and 25.8 g N m⁻² d⁻¹, respectively. Therefore, the AP valorization through the AD process, followed by N recovery from the digestate, could be a good management strategy. Full article

(This article belongs to the Special Issue Novel Membranes for Molecular Separations)

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Open AccessFeature PaperEditor’s ChoiceArticle

Technical and Environmental Feasibilities of the Commercial Production of NaOH from Brine by Means of an Integrated EDBM and Evaporation Process

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Marta Herrero-Gonzalez

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Raquel Ibañez

Membranes 2022, 12(9), 885; https://doi.org/10.3390/membranes12090885 - 14 Sep 2022

Cited by 1 | Viewed by 1022

Abstract

Electrodialysis with bipolar membranes (EDBMs) is a technology that offers a great potential for the introduction of the principles of a circular economy in the desalination industry, by providing a strategy for the recovery of HCl and NaOH from brine via the process [...] Read more.

Electrodialysis with bipolar membranes (EDBMs) is a technology that offers a great potential for the introduction of the principles of a circular economy in the desalination industry, by providing a strategy for the recovery of HCl and NaOH from brine via the process of seawater reverse osmosis (SWRO). Both chemicals are widely employed in desalination facilities, however NaOH presents a special interest due to its higher requirements and cost. Nevertheless, the standard commercial concentrations that are commonly employed in the facilities cannot be obtained using the state of the art EDBM technology itself. Therefore, the aim and main purpose of this work is to prove the technical and environmental feasibilities of a new approach to produce commercial NaOH (50%wt.) from SWRO brine by means of an integrated process of EDBMs followed by a triple effect evaporation. The global process has been technically evaluated in terms of the specific energy consumption (SEC) (kWh·kg⁻¹ NaOH) and the environmental sustainability performance has been analyzed by its carbon footprint (CF) (kg CO₂-eq.·kg⁻¹ NaOH). The influence of the current density, and the power source in the EDBM stage have been evaluated on a laboratory scale while the influence of the feed stream concentration in the evaporation stage has been obtained through simulations using Aspen Plus. The lowest SEC of the integrated process (SEC_OV), 31.1 kWh·kg⁻¹ NaOH, is obtained when an average current density of 500 A·m⁻², provided by a power supply (grid mix), is applied in the EDBM stage. The environmental burdens of the integrated process have been quantified by achieving reductions in the CF by up to 54.7% when solar photovoltaic energy is employed as the power source for EDBMs, with a value of 5.38 kg CO₂-eq.·kg⁻¹ NaOH. This study presents a great potential for the introduction of the principles of a circular economy in the water industry through the recovery of NaOH from the high salinity waste stream generated in SWRO facilities and opens the possibility of the reuse of NaOH by its self-supply in the desalination plant. Full article

(This article belongs to the Special Issue Advance in Electromembrane Technology)

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Open AccessFeature PaperEditor’s ChoiceArticle

Using Al³⁺ to Tailor Graphene Oxide Nanochannels: Impact on Membrane Stability and Permeability

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Membranes 2022, 12(9), 871; https://doi.org/10.3390/membranes12090871 - 09 Sep 2022

Cited by 2 | Viewed by 948

Abstract

Graphene oxide (GO) membranes, which form from the lamination of GO sheets, attract much attention due to their unique nanochannels. There is much interest in controlling the nanochannel structures and improving the aqueous stability of GO membranes so they can be effectively used [...] Read more.

Graphene oxide (GO) membranes, which form from the lamination of GO sheets, attract much attention due to their unique nanochannels. There is much interest in controlling the nanochannel structures and improving the aqueous stability of GO membranes so they can be effectively used in separation and filtration applications. This study employed a simple yet effective method of introducing trivalent aluminum cations to a GO sheet solution through the oxidation of aluminum foil, which modifies the nanochannels in the self-assembled GO membrane by increasing the inter-sheet distance while decreasing intra-sheet spacing. The Al³⁺ modification resulted in an increase in membrane stability in water, methanol, ethanol, and propanol, yet decreased membrane permeability to water and propanol. These changes were attributed to strong interactions between Al³⁺ and the membrane oxygenated functional groups, which resulted in an increase in membrane hydrophobicity and a decrease in the intra-sheet spacing as supported by surface tension, contact angle, atomic force microscopy, and X-ray photoelectron spectroscopy measurements. Our approach for forming Al³⁺ modified GO membranes provides a method for improving the aqueous stability and tailoring the permeation selectivity of GO membranes, which have the potential to be implemented in vapor separation and fuel purification applications. Full article

(This article belongs to the Section Membrane Surfaces and Interfaces)

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Open AccessFeature PaperEditor’s ChoiceReview

Modelling Sorption and Transport of Gases in Polymeric Membranes across Different Scales: A Review

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Eleonora Ricci

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Matteo Minelli

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Maria Grazia De Angelis

Membranes 2022, 12(9), 857; https://doi.org/10.3390/membranes12090857 - 31 Aug 2022

Cited by 3 | Viewed by 2578

Abstract

Professor Giulio C. Sarti has provided outstanding contributions to the modelling of fluid sorption and transport in polymeric materials, with a special eye on industrial applications such as membrane separation, due to his Chemical Engineering background. He was the co-creator of innovative theories [...] Read more.

Professor Giulio C. Sarti has provided outstanding contributions to the modelling of fluid sorption and transport in polymeric materials, with a special eye on industrial applications such as membrane separation, due to his Chemical Engineering background. He was the co-creator of innovative theories such as the Non-Equilibrium Theory for Glassy Polymers (NET-GP), a flexible tool to estimate the solubility of pure and mixed fluids in a wide range of polymers, and of the Standard Transport Model (STM) for estimating membrane permeability and selectivity. In this review, inspired by his rigorous and original approach to representing membrane fundamentals, we provide an overview of the most significant and up-to-date modeling tools available to estimate the main properties governing polymeric membranes in fluid separation, namely solubility and diffusivity. The paper is not meant to be comprehensive, but it focuses on those contributions that are most relevant or that show the potential to be relevant in the future. We do not restrict our view to the field of macroscopic modelling, which was the main playground of professor Sarti, but also devote our attention to Molecular and Multiscale Hierarchical Modeling. This work proposes a critical evaluation of the different approaches considered, along with their limitations and potentiality. Full article

(This article belongs to the Special Issue Fundamentals of Transport in Polymers and Membranes—Honorary Issue for Professor Giulio C. Sarti)

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Open AccessFeature PaperEditor’s ChoiceArticle

Polymer Electrolytes Based on Na-Nafion Plasticized by Binary Mixture of Ethylene Carbonate and Sulfolane

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Membranes 2022, 12(9), 840; https://doi.org/10.3390/membranes12090840 - 29 Aug 2022

Cited by 2 | Viewed by 1159

Abstract

The development of post-lithium current sources, such as sodium-ion batteries with improved energy characteristics and an increased level of safety, is one of the key issues of modern energy. It requires the search and study of materials (including electrolytes) for these devices. Polyelectrolytes [...] Read more.

The development of post-lithium current sources, such as sodium-ion batteries with improved energy characteristics and an increased level of safety, is one of the key issues of modern energy. It requires the search and study of materials (including electrolytes) for these devices. Polyelectrolytes with unipolar cationic conductivity based on Nafion^® membranes are promising. In this work, the effect of swelling conditions of the Nafion^® 115 membrane in Na⁺-form with mixtures of aprotic solvents such as ethylene carbonate and sulfolane on its physicochemical and electrotransport properties was studied. Nafion-Na⁺ membranes were swollen in a mixture of solvents at temperatures of 40, 60, and 80 °C. The results were obtained using methods of impedance spectroscopy, simultaneous thermal analysis, and IR spectroscopy. The best conductivity was observed for a membrane swelling at 80 °C in a mixture with a mass fraction of ethylene carbonate of 0.5, which reaches 10⁻⁴ S cm⁻¹ at 30 °C and retains rather high values down to −60 °C (10⁻⁶ S cm⁻¹). Thus, it is possible to expand the operating temperature range of a sodium battery by varying the composition of the polymer electrolyte and the conditions for its preparation. Full article

(This article belongs to the Special Issue Membranes for Energy Conversion)

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Open AccessFeature PaperEditor’s ChoiceArticle

Novel PDMS-b-PPO Membranes Modified with Graphene Oxide for Efficient Pervaporation Ethanol Dehydration

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Membranes 2022, 12(9), 832; https://doi.org/10.3390/membranes12090832 - 25 Aug 2022

Cited by 5 | Viewed by 1123

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Purification and concentration of bioalcohols is gaining new status due to their use as a promising alternative liquid biofuel. In this work, novel high-performance asymmetric membranes based on a block copolymer (BCP) synthesized from polydimethylsiloxane (PDMS) and poly(2,6-dimethyl-1,4-phenylene oxide) (PPO) were developed for [...] Read more.

Purification and concentration of bioalcohols is gaining new status due to their use as a promising alternative liquid biofuel. In this work, novel high-performance asymmetric membranes based on a block copolymer (BCP) synthesized from polydimethylsiloxane (PDMS) and poly(2,6-dimethyl-1,4-phenylene oxide) (PPO) were developed for enhanced pervaporation dehydration of ethanol. Improvement in dehydration performance was achieved by obtaining BCP membranes with a “non-perforated” porous structure and through surface and bulk modifications with graphene oxide (GO). Formation of the BCP was confirmed by Fourier-transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopies. The changes to morphology and physicochemical properties of the developed BCP and BCP/GO membranes were studied by scanning electron (SEM) and atomic force (AFM) microscopies, thermogravimetric analysis (TGA) and contact angle measurements. Transport properties of the developed membranes were evaluated by the pervaporation dehydration of ethanol over a wide concentration range (4.4–70 wt.% water) at 22 °C. The BCP (PDMS:PPO:2,4-diisocyanatotoluene = 41:58:1 wt.% composition) membrane modified with 0.7 wt.% GO demonstrated optimal transport characteristics: 80–90 g/(m²h) permeation flux with high selectivity (76.8–98.8 wt.% water in the permeate, separation factor of 72–34) and pervaporation separation index (PSI) of 5.5–2.9. Full article

(This article belongs to the Special Issue Enhanced Membrane Properties by Membrane Surface Modification and Functionalization)

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Open AccessFeature PaperEditor’s ChoiceArticle

Interaction of Bortezomib with Cell Membranes Regulates Its Toxicity and Resistance to Therapy

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Maria João Ramalho

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Stéphanie Andrade

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Joana Angélica Loureiro

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Maria Carmo Pereira

Membranes 2022, 12(9), 823; https://doi.org/10.3390/membranes12090823 - 23 Aug 2022

Cited by 1 | Viewed by 1126

Abstract

Bortezomib (BTZ) is a potent proteasome inhibitor currently being used to treat multiple myeloma. However, its high toxicity and resistance to therapy severely limit the treatment outcomes. Drug–membrane interactions have a crucial role in drugs’ behavior in vivo, affecting their bioavailability and pharmacological [...] Read more.

Bortezomib (BTZ) is a potent proteasome inhibitor currently being used to treat multiple myeloma. However, its high toxicity and resistance to therapy severely limit the treatment outcomes. Drug–membrane interactions have a crucial role in drugs’ behavior in vivo, affecting their bioavailability and pharmacological activity. Additionally, drugs’ toxicity often occurs due to their effects on the cell membranes. Therefore, studying BTZ’s interactions with cell membranes may explain the limitations of its therapy. Due to the cell membranes’ complexity, lipid vesicles were proposed here as biomembrane models, focusing on the membrane’s main constituents. Two models with distinct composition and complexity were used, one composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and the other containing DMPC, cholesterol (Chol), and sphingomyelin (SM). BTZ’s interactions with the models were evaluated regarding the drugs’ lipophilicity, preferential location, and effects on the membrane’s physical state. The studies were conducted at different pH values (7.4 and 6.5) to mimic the normal blood circulation and the intestinal environment, respectively. BTZ revealed a high affinity for the membranes, which proved to be dependent on the drug-ionization state and the membrane complexity. Furthermore, BTZ’s interactions with the cell membranes was proven to induce changes in the membrane fluidity. This may be associated with its resistance to therapy, since the activity of efflux transmembrane proteins is dependent on the membrane’s fluidity. Full article

(This article belongs to the Special Issue Nanotechnologies and Nanoparticles Interaction with Bio-membranes)

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Open AccessFeature PaperEditor’s ChoiceReview

Applications of Ionic Liquids in Carboxylic Acids Separation

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Alexandra Cristina Blaga

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Alexandra Tucaliuc

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Lenuta Kloetzer

Membranes 2022, 12(8), 771; https://doi.org/10.3390/membranes12080771 - 09 Aug 2022

Cited by 3 | Viewed by 1499

Abstract

Ionic liquids (ILs) are considered a green viable organic solvent substitute for use in the extraction and purification of biosynthetic products (derived from biomass—solid/liquid extraction, or obtained through fermentation—liquid/liquid extraction). In this review, we analyzed the ionic liquids (greener alternative for volatile organic [...] Read more.

Ionic liquids (ILs) are considered a green viable organic solvent substitute for use in the extraction and purification of biosynthetic products (derived from biomass—solid/liquid extraction, or obtained through fermentation—liquid/liquid extraction). In this review, we analyzed the ionic liquids (greener alternative for volatile organic media in chemical separation processes) as solvents for extraction (physical and reactive) and pertraction (extraction and transport through liquid membranes) in the downstream part of organic acids production, focusing on current advances and future trends of ILs in the fields of promoting environmentally friendly products separation. Full article

(This article belongs to the Special Issue Advanced Research in Ionic Liquid Membranes)

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Open AccessFeature PaperEditor’s ChoiceArticle

Sessile Drop Method: Critical Analysis and Optimization for Measuring the Contact Angle of an Ion-Exchange Membrane Surface

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Membranes 2022, 12(8), 765; https://doi.org/10.3390/membranes12080765 - 04 Aug 2022

Cited by 5 | Viewed by 2890

Abstract

The contact angle between a membrane surface and a waterdrop lying on its surface provides important information about the hydrophilicity/hydrophobicity of the membrane. This method is well-developed for solid non-swelling materials. However, ion-exchange membranes (IEMs) are gel-like solids that swell in liquids. When [...] Read more.

The contact angle between a membrane surface and a waterdrop lying on its surface provides important information about the hydrophilicity/hydrophobicity of the membrane. This method is well-developed for solid non-swelling materials. However, ion-exchange membranes (IEMs) are gel-like solids that swell in liquids. When an IEM is exposed to air, its degree of swelling changes rapidly, making it difficult to measure the contact angle. In this paper, we examine the known experience of measuring contact angles and suggest a simple equipment that allows the membrane to remain swollen during measurements. An optimized protocol makes it possible to obtain reliable and reproducible results. Measuring parameters such as drop size, water dosing speed and others are optimized. Contact angle measurements are shown for a large number of commercial membranes. These data are supplemented with values from other surface characteristics from optical and profilometric measurements. Full article

(This article belongs to the Special Issue Ion-Exchange Membranes and Processes (Volume III))

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Open AccessFeature PaperEditor’s ChoiceArticle

Modeling Adsorption, Conformation, and Orientation of the Fis1 Tail Anchor at the Mitochondrial Outer Membrane

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Beytullah Ozgur

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Cory D. Dunn

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Mehmet Sayar

Membranes 2022, 12(8), 752; https://doi.org/10.3390/membranes12080752 - 31 Jul 2022

Viewed by 1110

Abstract

Proteins can be targeted to organellar membranes by using a tail anchor (TA), a stretch of hydrophobic amino acids found at the polypeptide carboxyl-terminus. The Fis1 protein (Fis1p), which promotes mitochondrial and peroxisomal division in the yeast Saccharomyces cerevisiae, is targeted to [...] Read more.

Proteins can be targeted to organellar membranes by using a tail anchor (TA), a stretch of hydrophobic amino acids found at the polypeptide carboxyl-terminus. The Fis1 protein (Fis1p), which promotes mitochondrial and peroxisomal division in the yeast Saccharomyces cerevisiae, is targeted to those organelles by its TA. Substantial evidence suggests that Fis1p insertion into the mitochondrial outer membrane can occur without the need for a translocation machinery. However, recent findings raise the possibility that Fis1p insertion into mitochondria might be promoted by a proteinaceous complex. Here, we have performed atomistic and coarse-grained molecular dynamics simulations to analyze the adsorption, conformation, and orientation of the Fis1(TA). Our results support stable insertion at the mitochondrial outer membrane in a monotopic, rather than a bitopic (transmembrane), configuration. Once inserted in the monotopic orientation, unassisted transition to the bitopic orientation is expected to be blocked by the highly charged nature of the TA carboxyl-terminus and by the Fis1p cytosolic domain. Our results are consistent with a model in which Fis1p does not require a translocation machinery for insertion at mitochondria. Full article

(This article belongs to the Special Issue Molecular Simulations of Biomembranes: From Biophysics Fundamentals to Biological Function)

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ECTFE Membrane Fabrication Using Green Binary Diluents TEGDA/TOTM and Its Performance in Membrane Condenser

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Membranes 2022, 12(8), 757; https://doi.org/10.3390/membranes12080757 - 31 Jul 2022

Viewed by 1064

Abstract

Poly(ethylene-chlorotrifluoroethylene) (ECTFE) membrane is a hydrophobic membrane material that can be used to recover water from high-humidity gases in the membrane condenser (MC) process. In this study, ECTFE membranes were prepared by the thermally induced phase separation (TIPS) method using the green binary [...] Read more.

Poly(ethylene-chlorotrifluoroethylene) (ECTFE) membrane is a hydrophobic membrane material that can be used to recover water from high-humidity gases in the membrane condenser (MC) process. In this study, ECTFE membranes were prepared by the thermally induced phase separation (TIPS) method using the green binary diluents triglyceride diacetate (TEGDA) and trioctyl trimellitate (TOTM). Thermodynamic phase diagrams of the ECTFE/TEGDA: TOTM system were made. The effects of the diluent composition and cooling rate on the structure and properties of the ECTFE membranes were investigated by characterizing the SEM, contact angle, mechanical properties, pore size and porosity. The results showed that ECTFE membranes with cellular structure were successfully prepared and exhibit good mechanical properties. Moreover, increasing the TOTM content in the binary diluents and decreasing the cooling rate could effectively improve the mean pore size of the ECTFE membranes, but the increase in TOTM content reduced the mechanical properties. During the MC process, the water recovery performance of ECTFE membranes increased with the increase in the mean pore size of the membranes, and the condensation flow and water recovery of membrane prepared at 20% TOTM were 1.71 kg·m⁻²·h⁻¹ and 54.84%, respectively, which were better than the performance of commercial hydrophobic PVDF membranes in the MC. These results indicated that there is good potential for the application of ECTFE membranes during the MC process. Full article

(This article belongs to the Special Issue Environmentally Friendly Approaches for Fabrication of Filtration Membranes)

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Validation of Recycled Nanofiltration and Anion-Exchange Membranes for the Treatment of Urban Wastewater for Crop Irrigation

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Anamary Pompa-Pernía

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Serena Molina

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Amaia Lejarazu-Larrañaga

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Junkal Landaburu-Aguirre

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Eloy García-Calvo

Membranes 2022, 12(8), 746; https://doi.org/10.3390/membranes12080746 - 29 Jul 2022

Cited by 4 | Viewed by 1450

Abstract

One of the alternative sources to tackle the problem of water shortage is the use of reclaimed water from wastewater treatment plants for irrigation purposes. However, when the wastewater has a high conductivity value, it becomes unusable for crop irrigation and needs a [...] Read more.

One of the alternative sources to tackle the problem of water shortage is the use of reclaimed water from wastewater treatment plants for irrigation purposes. However, when the wastewater has a high conductivity value, it becomes unusable for crop irrigation and needs a more specific treatment. In this work, recycled nanofiltration (rNF) membranes and anion-exchange membranes (rAEMs) obtained from end-of-life RO membranes were validated to evaluate their application capability in saline wastewater treatment. The use of recycled membranes may represent an advantage due to their lower cost and reduced environmental impact associated with their production, which integrates membrane-based technology into a circular economy model. Both recycled membranes were tested in crossflow filtration and electrodialysis (ED) systems. The results of the rNF membrane showed a high selective rejection of divalent ions (SO₄²⁻ (>96%) and Ca²⁺ and Mg²⁺ (>93%)). In the case of the ED process, the comparison between rAEMs and commercial membranes showed an appropriate demineralization rate without compromising the power consumption. Finally, the quality of both system effluents was suitable for irrigation, which was compared to the WHO guideline and validated by the 7-week lettuce crop study. Full article

(This article belongs to the Special Issue Circular Economy in Membrane Technology)

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New Sustainable Multilayered Membranes Based on ZrVTi for Hydrogen Purification

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Membranes 2022, 12(7), 722; https://doi.org/10.3390/membranes12070722 - 21 Jul 2022

Cited by 2 | Viewed by 1205

Abstract

Some metals belonging to groups IV and V show a high permeability to hydrogen and have been studied as possible alternatives to palladium in membranes for hydrogen purification/separation in order to increase their sustainability and decrease their costs. However, to date, very few [...] Read more.

Some metals belonging to groups IV and V show a high permeability to hydrogen and have been studied as possible alternatives to palladium in membranes for hydrogen purification/separation in order to increase their sustainability and decrease their costs. However, to date, very few alloys among those metals have been investigated, and no membrane studies based on 4–5 element alloys with low or zero Pd content and quasi-amorphous structure have been reported so far. In this work, new membranes based on ZrVTi- and ZrVTiPd alloys were tested for the first time for this application. The unprecedented deposition of micrometric-based multilayers was performed via high-power impulse magnetron sputtering onto porous alumina substrates. Dense Pd/Zr_xV_yTi_zPd_w/Pd multilayers were obtained. The composition of the alloys, morphology and structure, hydrogen permeance, selectivity, and resistance to embrittlement were tested and analyzed depending on the deposition conditions, and the membrane with the enhanced performance was tuned. The environmental impact of these membranes was also investigated to ascertain the sustainability of these alloys relative to more common Pd₇₇Ag₂₃ and V₉₃Pd₇ thin-film membranes using a life cycle assessment analysis. The results showed that the partial substitution of Pd can efficiently lead to a decrease in the environmental impacts of the membranes. Full article

(This article belongs to the Section Inorganic Membranes)

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Partial Removal of Sugar from Apple Juice by Nanofiltration and Discontinuous Diafiltration

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Membranes 2022, 12(7), 712; https://doi.org/10.3390/membranes12070712 - 15 Jul 2022

Cited by 3 | Viewed by 1547

Abstract

Partial removal of sugars in fruit juices without compromising their biofunctional properties represents a significant technological challenge. The current study was aimed at evaluating the separation of sugars from phenolic compounds in apple juice by using three different spiral-wound nanofiltration (NF) membranes with [...] Read more.

Partial removal of sugars in fruit juices without compromising their biofunctional properties represents a significant technological challenge. The current study was aimed at evaluating the separation of sugars from phenolic compounds in apple juice by using three different spiral-wound nanofiltration (NF) membranes with a molecular weight cut-off (MWCO) in the range of 200–500 Da. A combination of diafiltration and batch concentration processes was investigated to produce apple juice with reduced sugar content and improved health properties thanks to the preservation and concentration of phenolic compounds. For all selected membranes, permeate flux and recovery rate of glucose, fructose, and phenolic compounds, in both diafiltration and concentration processes, were evaluated. The concentration factor of target compounds as a function of the volume reduction factor (VRF) as well as the amount of adsorbed compound on the membrane surface from mass balance analysis were also evaluated. Among the investigated membranes a thin-film composite membrane with an MWCO of 200–300 Da provided the best results in terms of the preservation of phenolic compounds in the selected operating conditions. More than 70% of phenolic compounds were recovered in the retentate stream while the content of sugars was reduced by about 60%. Full article

(This article belongs to the Special Issue Membrane Technologies for Sustainability)

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Open AccessFeature PaperEditor’s ChoiceArticle

A Study on Biofouling and Cleaning of Anion Exchange Membranes for Reverse Electrodialysis

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Gonçalo Tiago

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Maria Beatriz Cristóvão

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Ana Paula Marques

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Rosa Huertas

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Ivan Merino-Garcia

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Vanessa Jorge Pereira

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João Goulão Crespo

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Svetlozar Velizarov

Membranes 2022, 12(7), 697; https://doi.org/10.3390/membranes12070697 - 08 Jul 2022

Cited by 5 | Viewed by 1421

Abstract

This study covers the modification, (bio)fouling characterization, use, and cleaning of commercial heterogeneous anion exchange membranes (AEMs) to evaluate their feasibility for reverse electrodialysis (RED) applications. A surface modification with poly (acrylic) acid resulted in an improved monovalent perm-selectivity (decreased sulfate membrane transport [...] Read more.

This study covers the modification, (bio)fouling characterization, use, and cleaning of commercial heterogeneous anion exchange membranes (AEMs) to evaluate their feasibility for reverse electrodialysis (RED) applications. A surface modification with poly (acrylic) acid resulted in an improved monovalent perm-selectivity (decreased sulfate membrane transport rate). Moreover, we evaluated the (bio)fouling potential of the membrane using sodium dodecyl sulfate (SDS), sodium dodecyl benzenesulfonate (SDBS), and Aeromonas hydrophila as model organic foulants and a biofoulant, respectively. A detailed characterization of the AEMs (water contact angle, ion exchange capacity (IEC), scanning electron microscopy (SEM), cyclic voltammetry (CV), and Fourier Transform Infrared (FTIR) spectra) was carried out, verifying that the presence of such foulants reduces IEC and the maximum current obtained by CV. However, only SDS and SDBS affected the contact angle values. Cleaning of the biofouled membranes using a sodium hypochlorite aqueous solution allows for (partially) recovering their initial properties. Furthermore, this work includes a fouling characterization using real surface and sea water matrixes, confirming the presence of several types of fouling microorganisms in natural streams. A lower adhesion of microorganisms (measured in terms of total bacteria counts) was observed for the modified membranes compared to the unmodified ones. Finally, we propose a cleaning strategy to mitigate biofouling in AEMs that could be easily applied in RED systems for an enhanced long-term process performance. Full article

(This article belongs to the Special Issue Electrochemical Membranes: Materials, Characterization, Testing, and Cleaning)

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Open AccessFeature PaperEditor’s ChoiceArticle

Cellulose Nanocrystals Crosslinked with Sulfosuccinic Acid as Sustainable Proton Exchange Membranes for Electrochemical Energy Applications

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Membranes 2022, 12(7), 658; https://doi.org/10.3390/membranes12070658 - 26 Jun 2022

Cited by 3 | Viewed by 2114

Abstract

Nanocellulose is a sustainable material which holds promise for many energy-related applications. Here, nanocrystalline cellulose is used to prepare proton exchange membranes (PEMs). Normally, this nanomaterial is highly dispersible in water, preventing its use as an ionomer in many electrochemical applications. To solve [...] Read more.

Nanocellulose is a sustainable material which holds promise for many energy-related applications. Here, nanocrystalline cellulose is used to prepare proton exchange membranes (PEMs). Normally, this nanomaterial is highly dispersible in water, preventing its use as an ionomer in many electrochemical applications. To solve this, we utilized a sulfonic acid crosslinker to simultaneously improve the mechanical robustness, water-stability, and proton conductivity (by introducing -SO₃⁻H⁺ functional groups). The optimization of the proportion of crosslinker used and the crosslinking reaction time resulted in enhanced proton conductivity up to 15 mS/cm (in the fully hydrated state, at 120 °C). Considering the many advantages, we believe that nanocellulose can act as a sustainable and low-cost alternative to conventional, ecologically problematic, perfluorosulfonic acid ionomers for applications in, e. fuel cells and electrolyzers. Full article

(This article belongs to the Special Issue Cellulose Membranes: From Synthesis to Applications)

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Novel Thin Film Nanocomposite Membranes Based on Chitosan Succinate Modified with Fe-BTC for Enhanced Pervaporation Dehydration of Isopropanol

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Alexandr Bildyukevich

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Sergey Ermakov

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Anastasia Penkova

Membranes 2022, 12(7), 653; https://doi.org/10.3390/membranes12070653 - 25 Jun 2022

Cited by 7 | Viewed by 1295

Abstract

The application of environmentally friendly and energy-efficient membrane processes allows improvement the ecological safety and sustainability of industrial production. However, the effective application of membrane processes requires novel high-performance thin film composite (TFC) membranes based on biopolymers to solve environmental problems. In this [...] Read more.

The application of environmentally friendly and energy-efficient membrane processes allows improvement the ecological safety and sustainability of industrial production. However, the effective application of membrane processes requires novel high-performance thin film composite (TFC) membranes based on biopolymers to solve environmental problems. In this work for the first time novel thin film nanocomposite (TFN) membranes based on biopolymer chitosan succinate (ChS) modified with the metal organic framework iron 1,3,5-benzenetricarboxylate (Fe-BTC) were developed for enhanced pervaporation dehydration. The formation of a selective layer of TFN membranes on the porous membrane-support was carried out by two methods—dynamic technique and physical adsorption. The effect of the membrane formation method and Fe-BTC content in ChS layer on the structure and physicochemical properties of TFN membranes was investigated. The developed TFN ChS-based membranes were evaluated in the pervaporation dehydration of isopropanol (12–30 wt.% water). It was found that TFN ChS-Fe-BTC membranes prepared by two methods demonstrated improved permeation flux compared to the reference TFC ChS membrane. The best transport properties in pervaporation dehydration of isopropanol (12–30 wt.% water) were possessed by TFN membranes with 40 wt.% Fe-BTC prepared by dynamic technique (permeation flux 99–499 g m⁻² h⁻¹ and 99.99% water in permeate) and TFN membranes with 5 wt.% Fe-BTC developed by physical adsorption (permeation flux 180–701 g m⁻² h⁻¹ and 99.99% water in permeate). Full article

(This article belongs to the Special Issue Development, Investigation and Application of Novel Polymer Membranes)

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Wicking in Porous Polymeric Membranes: Determination of an Effective Capillary Radius to Predict the Flow Behavior in Lateral Flow Assays

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Membranes 2022, 12(7), 638; https://doi.org/10.3390/membranes12070638 - 21 Jun 2022

Cited by 3 | Viewed by 1347

Abstract

The working principle of lateral flow assays, such as the widely used COVID-19 rapid tests, is based on the capillary-driven liquid transport of a sample fluid to a test line using porous polymeric membranes as the conductive medium. In order to predict this [...] Read more.

The working principle of lateral flow assays, such as the widely used COVID-19 rapid tests, is based on the capillary-driven liquid transport of a sample fluid to a test line using porous polymeric membranes as the conductive medium. In order to predict this wicking process by simplified analytical models, it is essential to determine an effective capillary radius for the highly porous and open-pored membranes. In this work, a parametric study is performed with selected simplified structures, representing the complex microstructure of the membrane. For this, a phase-field approach with a special wetting boundary condition to describe the meniscus formation and the corresponding mean surface curvature for each structure setup is used. As a main result, an analytical correlation between geometric structure parameters and an effective capillary radius, based on a correction factor, are obtained. The resulting correlation is verified by applying image analysis methods on reconstructed computer tomography scans of two different porous polymeric membranes and thus determining the geometric structure parameters. Subsequently, a macroscale flow model that includes the correlated effective pore size and geometrical capillary radius is applied, and the results are compared with wicking experiments. Based on the derived correction function, it is shown that the analytical prediction of the wicking process in highly porous polymeric membranes is possible without the fitting of experimental wicking data. Furthermore, it can be seen that the estimated effective pore radius of the two membranes is 8 to 10 times higher than their geometric mean pore radii. Full article

(This article belongs to the Special Issue Functional Porous Membranes for Energy, Environmental and Biomedical Applications)

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Open AccessEditor’s ChoiceArticle

Semi-Quantitative Evaluation of Asymmetricity of Dialysis Membrane Using Forward and Backward Ultrafiltration

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Membranes 2022, 12(6), 624; https://doi.org/10.3390/membranes12060624 - 15 Jun 2022

Viewed by 1201

Abstract

Performance of the dialysis membrane is strongly dependent upon the physicochemical structure of the membrane. The objective of this study is to devise a new in vitro evaluation technique to quantify the physicochemical structures of the membrane. Three commercial dialyzers with cellulose triacetate [...] Read more.

Performance of the dialysis membrane is strongly dependent upon the physicochemical structure of the membrane. The objective of this study is to devise a new in vitro evaluation technique to quantify the physicochemical structures of the membrane. Three commercial dialyzers with cellulose triacetate (CTA), asymmetric CTA (termed ATA^®), and polyether sulfone (PES) membranes (Nipro Co., Osaka, Japan) were employed for investigation. Forward and backward ultrafiltration experiments were performed separately with aqueous vitamin B₁₂ (MW 1355), α-chymotrypsin (MW 25,000), albumin (MW 66,000) and dextran solutions, introducing the test solution inside or outside the hollow fiber (HF), respectively. Sieving coefficients (s.c.) for these solutes were measured under the test solution flow rate of 200 mL/min and the ultrafiltration rate of 10 mL/min at 310 K, according to the guidelines provided by Japanese academic societies. We defined the ratio of s.c. in the backward ultrafiltration to that in the forward ultrafiltration and termed it the index for asymmetricity (IA). The IA values were unity for vitamin B₁₂ and α-chymotrypsin in all three of the dialyzers. The IA values for albumin, however, were 1.0 in CTA, 1.9 in ATA^®, and 3.9 in PES membranes, respectively, which corresponded well with the fact that CTA is homogeneous, whereas ATA^® and PES are asymmetrical in structure. Moreover, the asymmetricity of ATA^® and PES may be different by twofold. This fact was verified in continuous basis by employing dextran solution before and after being fouled with albumin. These findings may contribute to the development of a novel membrane for improved success of dialysis therapy. Full article

(This article belongs to the Special Issue Membranes in Biomedical Engineering: Assisting Clinical Engineers)

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Open AccessEditor’s ChoiceArticle

Reagent-Free Immobilization of Industrial Lipases to Develop Lipolytic Membranes with Self-Cleaning Surfaces

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Membranes 2022, 12(6), 599; https://doi.org/10.3390/membranes12060599 - 09 Jun 2022

Cited by 2 | Viewed by 1462

Abstract

Biocatalytic membrane reactors combine the highly efficient biotransformation capability of enzymes with the selective filtration performance of membrane filters. Common strategies to immobilize enzymes on polymeric membranes are based on chemical coupling reactions. Still, they are associated with drawbacks such as long reaction [...] Read more.

Biocatalytic membrane reactors combine the highly efficient biotransformation capability of enzymes with the selective filtration performance of membrane filters. Common strategies to immobilize enzymes on polymeric membranes are based on chemical coupling reactions. Still, they are associated with drawbacks such as long reaction times, high costs, and the use of potentially toxic or hazardous reagents. In this study, a reagent-free immobilization method based on electron beam irradiation was investigated, which allows much faster, cleaner, and cheaper fabrication of enzyme membrane reactors. Two industrial lipase enzymes were coupled onto a polyvinylidene fluoride (PVDF) flat sheet membrane to create self-cleaning surfaces. The response surface methodology (RSM) in the design-of-experiments approach was applied to investigate the effects of three numerical factors on enzyme activity, yielding a maximum activity of 823 ± 118 U m⁻² (enzyme concentration: 8.4 g L⁻¹, impregnation time: 5 min, irradiation dose: 80 kGy). The lipolytic membranes were used in fouling tests with olive oil (1 g L⁻¹ in 2 mM sodium dodecyl sulfate), resulting in 100% regeneration of filtration performance after 3 h of self-cleaning in an aqueous buffer (pH 8, 37 °C). Reusability with three consecutive cycles demonstrates regeneration of 95%. Comprehensive membrane characterization was performed by determining enzyme kinetic parameters, permeance monitoring, X-ray photoelectron spectroscopy, FTIR spectroscopy, scanning electron microscopy, and zeta potential, as well as water contact angle measurements. Full article

(This article belongs to the Special Issue Advances in Porous and Dense Membranes: Fabrication and Applications)

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Modification of Polyacrylonitrile Ultrafiltration Membranes to Enhance the Adsorption of Cations and Anions

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Anthony Arvind Kishore Chand

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Membranes 2022, 12(6), 580; https://doi.org/10.3390/membranes12060580 - 31 May 2022

Cited by 8 | Viewed by 1858

Abstract

Ion adsorbing ultrafiltration membranes provide an interesting possibility to remove toxic ions from water. Furthermore, it is also possible to recover valuable elements. In this work, we demonstrate two easy strategies to modify polyacrylonitrile membranes with anion and cation adsorbing groups. The membranes [...] Read more.

Ion adsorbing ultrafiltration membranes provide an interesting possibility to remove toxic ions from water. Furthermore, it is also possible to recover valuable elements. In this work, we demonstrate two easy strategies to modify polyacrylonitrile membranes with anion and cation adsorbing groups. The membranes were modified to have positively charged amine groups or negatively charged carboxyl groups. The success of the reactions was confirmed using IR spectroscopy and zeta-potential measurements. The membranes carrying negatively charged groups provided a negative zeta-potential and had an isoelectric point at pH 3.6, while the membranes carrying positively charged groups had a positive zeta-potential in the analyzed pH range. Since only the surface of the polymer was modified, the pore size and permeance of the membranes were not drastically affected. The membranes prepared by both modification strategies had a pure water permeance higher than 1000 L/(m² h bar) and a water contact angle of 44.3 and 57.2°, respectively. Therefore, the membranes can be operated at low pressures with reasonable flux. Additionally, SEM images showed that the membranes were still open-pored. Adsorption tests using a positively and a negatively charged dye as well as a toxic cation and an anion were performed to analyze the adsorption behavior. Both membranes were able to adsorb the oppositely charged dyes as well as the copper and chromate ions. Therefore, these membranes are good candidates to purify water streams containing hazardous ions. Full article

(This article belongs to the Special Issue Selected Papers from Euromembrane 2021)

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Effect of Melissa officinalis L. Essential Oil Nanoemulsions on Structure and Properties of Carboxymethyl Chitosan/Locust Bean Gum Composite Films

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Membranes 2022, 12(6), 568; https://doi.org/10.3390/membranes12060568 - 30 May 2022

Cited by 4 | Viewed by 1531

Abstract

This study aimed to develop active films based on carboxymethyl chitosan (CMCS)/locust bean gum (LBG) films containing Melissa officinalis L. essential oil (MOEO) nanoemulsions. The results showed that the active films incorporated with MOEO nanoemulsion resulted in an increase in the elongation of [...] Read more.

This study aimed to develop active films based on carboxymethyl chitosan (CMCS)/locust bean gum (LBG) films containing Melissa officinalis L. essential oil (MOEO) nanoemulsions. The results showed that the active films incorporated with MOEO nanoemulsion resulted in an increase in the elongation of break, water resistance and improved the film hydrophilicity. Elongation of break increased from 18.49% to 27.97% with the addition of 4% MOEO nanoemulsion. Water resistance was decreased from 56.32% to 25.43%, and water contact angle was increased from 75.13 to 83.86 with the addition of 4% MOEO nanoemulsion. However, the water vapor barrier properties and tensile strength decreased with the addition of MOEO nanoemulsions. The scanning electron microscopic images and Fourier transform infrared spectroscopy results showed that the MOEO was very compatible with the film materials and dispersed evenly in the films. At the same time, the addition of MOEO nanoemulsion significantly enhanced antioxidant and antibacterial activities of C/L-MOEO films. The antioxidant and antimicrobial activities of C/L-MOEO films were increased from 7.16% to 33.81% and 3.52% to 54.50%, respectively. In general, C/L-MOEO film has great application prospects. Full article

(This article belongs to the Special Issue Advanced Nanomembranes for Food and Food-Packaging Applications)

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Formation of a Fully Anionic Supported Lipid Bilayer to Model Bacterial Inner Membrane for QCM-D Studies

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Kathleen W. Swana

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Terri A. Camesano

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Ramanathan Nagarajan

Membranes 2022, 12(6), 558; https://doi.org/10.3390/membranes12060558 - 27 May 2022

Cited by 4 | Viewed by 1847

Abstract

Supported lipid bilayers (SLBs) on quartz crystals are employed as versatile model systems for studying cell membrane behavior with the use of the highly sensitive technique of quartz crystal microbalance with dissipation monitoring (QCM-D). Since the lipids constituting cell membranes vary from predominantly [...] Read more.

Supported lipid bilayers (SLBs) on quartz crystals are employed as versatile model systems for studying cell membrane behavior with the use of the highly sensitive technique of quartz crystal microbalance with dissipation monitoring (QCM-D). Since the lipids constituting cell membranes vary from predominantly zwitterionic lipids in mammalian cells to predominantly anionic lipids in the inner membrane of Gram-positive bacteria, the ability to create SLBs of different lipid compositions is essential for representing different cell membranes. While methods to generate stable zwitterionic SLBs and zwitterionic-dominant mixed zwitterionic–anionic SLBs on quartz crystals have been well established, there are no reports of being able to form predominantly or fully anionic SLBs. We describe here a method for forming entirely anionic SLBs by treating the quartz crystal with cationic (3-aminopropyl) trimethoxysilane (APTMS). The formation of the anionic SLB was tracked using QCM-D by monitoring the adsorption of anionic lipid vesicles to a quartz surface and subsequent bilayer formation. Anionic egg L-α-phosphatidylglycerol (PG) vesicles adsorbed on the surface-treated quartz crystal, but did not undergo the vesicle-to-bilayer transition to create an SLB. However, when PG was mixed with 10–40 mole% 1-palmitoyl-2-hydroxy-sn-glycero-3-phospho-(1′-rac-glycerol) (LPG), the mixed vesicles led to the formation of stable SLBs. The dynamics of SLB formation monitored by QCM-D showed that while SLB formation by zwitterionic lipids followed a two-step process of vesicle adsorption followed by the breakdown of the adsorbed vesicles (which in turn is a result of multiple events) to create the SLB, the PG/LPG mixed vesicles ruptured immediately on contacting the quartz surface resulting in a one-step process of SLB formation. The QCM-D data also enabled the quantitative characterization of the SLB by allowing estimation of the lipid surface density as well as the thickness of the hydrophobic region of the SLB. These fully anionic SLBs are valuable model systems to conduct QCM-D studies of the interactions of extraneous substances such as antimicrobial peptides and nanoparticles with Gram-positive bacterial membranes. Full article

(This article belongs to the Special Issue Model Lipid Membrane)

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A Rotary Spacer System for Energy-Efficient Membrane Fouling Control in Oil/Water Emulsion Filtration

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Nik Abdul Hadi Md Nordin

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Mohd Dzul Hakim Wirzal

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Norazanita Shamsuddin

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Hazwani Suhaimi

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Norhaniza Yusof

Membranes 2022, 12(6), 554; https://doi.org/10.3390/membranes12060554 - 26 May 2022

Cited by 4 | Viewed by 1560

Abstract

Membrane fouling deteriorates membrane filtration performances. Hence, mitigating membrane fouling is the key factor in sustaining the membrane process, particularly when treating fouling-prone feed, such as oil/water emulsions. The use of spacers has been expanded in the membrane module system, including for membrane [...] Read more.

Membrane fouling deteriorates membrane filtration performances. Hence, mitigating membrane fouling is the key factor in sustaining the membrane process, particularly when treating fouling-prone feed, such as oil/water emulsions. The use of spacers has been expanded in the membrane module system, including for membrane fouling control. This study proposed a rotating spacer system to ameliorate membrane fouling issues when treating an oil/water emulsion. The system’s effectiveness was assessed by investigating the effect of rotating speed and membrane-to-disk gap on the hydraulic performance and the energy input and through computational fluid dynamics (CFD) simulation. The results showed that the newly developed rotary spacer system was effective and energy-efficient for fouling control. The CFD simulation results proved that the spacer rotations induced secondary flow near the membrane surface and imposed shear rate and lift force to exert fouling control. Increasing the rotation speed to an average linear velocity of 0.44 m/s increased the permeability from 126.8 ± 2.1 to 175.5 ± 2.7 Lm⁻²h⁻¹bar⁻¹. The system showed better performance at a lower spacer-to-membrane gap, in which increasing the gap from 0.5 to 2.0 cm lowered the permeability from 175.5 ± 2.7 to 126.7 ± 2.0 Lm⁻²h⁻¹bar⁻¹. Interestingly, the rotary system showed a low energy input of 1.08 to 4.08 × 10⁻³ kWhm⁻³ permeate when run at linear velocities of 0.27 to 0.44 ms⁻¹. Overall, the findings suggest the competitiveness of the rotary spacer system as a method for membrane fouling control. Full article

(This article belongs to the Special Issue Advanced Polymeric Membranes for Energy & Environment)

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Open AccessEditor’s ChoiceReview

State-of-the-Art Organic- and Inorganic-Based Hollow Fiber Membranes in Liquid and Gas Applications: Looking Back and Beyond

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Membranes 2022, 12(5), 539; https://doi.org/10.3390/membranes12050539 - 22 May 2022

Cited by 11 | Viewed by 5032

Abstract

The aggravation of environmental problems such as water scarcity and air pollution has called upon the need for a sustainable solution globally. Membrane technology, owing to its simplicity, sustainability, and cost-effectiveness, has emerged as one of the favorable technologies for water and air [...] Read more.

The aggravation of environmental problems such as water scarcity and air pollution has called upon the need for a sustainable solution globally. Membrane technology, owing to its simplicity, sustainability, and cost-effectiveness, has emerged as one of the favorable technologies for water and air purification. Among all of the membrane configurations, hollow fiber membranes hold promise due to their outstanding packing density and ease of module assembly. Herein, this review systematically outlines the fundamentals of hollow fiber membranes, which comprise the structural analyses and phase inversion mechanism. Furthermore, illustrations of the latest advances in the fabrication of organic, inorganic, and composite hollow fiber membranes are presented. Key findings on the utilization of hollow fiber membranes in microfiltration (MF), nanofiltration (NF), reverse osmosis (RO), forward osmosis (FO), pervaporation, gas and vapor separation, membrane distillation, and membrane contactor are also reported. Moreover, the applications in nuclear waste treatment and biomedical fields such as hemodialysis and drug delivery are emphasized. Subsequently, the emerging R&D areas, precisely on green fabrication and modification techniques as well as sustainable materials for hollow fiber membranes, are highlighted. Last but not least, this review offers invigorating perspectives on the future directions for the design of next-generation hollow fiber membranes for various applications. As such, the comprehensive and critical insights gained in this review are anticipated to provide a new research doorway to stimulate the future development and optimization of hollow fiber membranes. Full article

(This article belongs to the Special Issue Hollow Fiber Membranes: Past, Present and Future)

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Open AccessEditor’s ChoiceArticle

Separation of Mercury(II) from Industrial Wastewater through Polymer Inclusion Membranes with Calix[4]pyrrole Derivative

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Membranes 2022, 12(5), 492; https://doi.org/10.3390/membranes12050492 - 30 Apr 2022

Cited by 6 | Viewed by 1629

Abstract

Polymer membranes with immobilized ligands are encouraging alternatives for the removal of toxic metal ions from aquatic waste streams, including industrial wastewater, in view of their high selectivity, stability, removal efficacy and low energy demands. In this study, polymer inclusion membranes (PIMs) based [...] Read more.

Polymer membranes with immobilized ligands are encouraging alternatives for the removal of toxic metal ions from aquatic waste streams, including industrial wastewater, in view of their high selectivity, stability, removal efficacy and low energy demands. In this study, polymer inclusion membranes (PIMs) based on cellulose triacetate, with a calix[4]pyrrole derivative as an ion carrier, were tested for their capability to dispose mercury (Hg(II)) ions from industrial wastewater. The impacts were assessed relative to carrier content, the quantity of plasticizer in the membrane, the hydrocholoric acid concentration in the source phase, and the character of the receiving phase on the performance of Hg(II) elimination. Optimally designed PIMs could be an interesting option for the industrial wastewater treatment due to the high removal efficiency of Hg(II) and great repeatability. Full article

(This article belongs to the Special Issue Advanced Membrane Technologies for Water and Wastewater Treatment)

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Open AccessEditor’s ChoiceArticle

Application of Cyclized Polyacrylonitrile for Ultrafiltration Membrane Fouling Mitigation

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Membranes 2022, 12(5), 489; https://doi.org/10.3390/membranes12050489 - 30 Apr 2022

Cited by 4 | Viewed by 1449

Abstract

In this study, novel composites were produced by blending partially cyclized polyacrylonitrile (cPAN) and poly(amide-imide) (PAI) in N-methylpyrrolidone in order to fabricate asymmetric membranes via phase inversion method. The compatibility of PAI and cPAN through possible intermolecular interaction was examined [...] Read more.

In this study, novel composites were produced by blending partially cyclized polyacrylonitrile (cPAN) and poly(amide-imide) (PAI) in N-methylpyrrolidone in order to fabricate asymmetric membranes via phase inversion method. The compatibility of PAI and cPAN through possible intermolecular interaction was examined by quantum chemical calculations. The composite membranes were characterized by FTIR, SEM, contact angle measurements, etc. A considerable reduction in the contact angles of water and ethylene glycol (EG) was observed after adding cPAN to the PAI membrane, which is evidence of improved membrane hydrophilicity. Membrane transport properties were investigated in ultrafiltration tests by measuring the pure water flux, rejection of proteins, and flux recovery ratio (FRR). The best properties were found for the membrane containing 5 wt% cPAN; an increase in BSA rejection and a remarkable increase in FRR were observed, which can be explained by the hydrophilization of the membrane surface provided by the presence of cPAN. Full article

(This article belongs to the Special Issue Development, Investigation and Application of Novel Polymer Membranes)

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Open AccessEditor’s ChoiceArticle

Effects of Different Draw Solutions on Biogas Slurry Concentration in Forward Osmosis Membrane: Performance and Membrane Fouling

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Membranes 2022, 12(5), 476; https://doi.org/10.3390/membranes12050476 - 28 Apr 2022

Cited by 4 | Viewed by 1220

Abstract

Biogas slurry poses a severe challenge to the sustainable management of livestock farms. The technology of the forward osmosis (FO) membrane has a good application prospect in the field of biogas slurry concentration. Further research is needed to verify the effects of different [...] Read more.

Biogas slurry poses a severe challenge to the sustainable management of livestock farms. The technology of the forward osmosis (FO) membrane has a good application prospect in the field of biogas slurry concentration. Further research is needed to verify the effects of different draw solutions on FO membranes in biogas slurry treatment and the related membrane fouling characteristics. In this study, three different draw solutions were selected to evaluate the performance of FO membranes for biogas slurry concentration. Membrane fouling was investigated by characterization after FO membrane treatment to identify fouling contaminants. The result showed that FO membrane treatment can realize the concentration of biogas slurry and MgCl₂ as the draw solution has the best effect on the concentration of biogas slurry. The different draw solutions all contributed to the efficient retention of most organics and TP while each treatment was ineffective at retaining nitrogen. The cake layer that appeared after the biogas slurry was concentrated covered the surface of the FO membrane. Some functional groups were detected on the surface after membrane fouling, such as C–O and C=C. Moreover, the C element accounts for 57% of the main components of the cake layer after the membrane fouling. Membrane fouling is caused by both organic fouling and inorganic fouling, of which organic fouling is the main reason. This study provides a technical reference for the high-value utilization of biogas slurry. Full article

(This article belongs to the Section Membrane Applications)

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Open AccessEditor’s ChoiceArticle

Pilot Scale Application of a Ceramic Membrane Bioreactor for Treating High-Salinity Oil Production Wastewater

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Ronglin Sun

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Yue Jin

Membranes 2022, 12(5), 473; https://doi.org/10.3390/membranes12050473 - 27 Apr 2022

Cited by 1 | Viewed by 1583

Abstract

The offshore oil extraction process generates copious amounts of high-salinity oil-bearing wastewater; at present, treating such wastewater in an efficient and low-consumption manner is a major challenge. In this study, a flat ceramic membrane bioreactor (C−MBR) process combining aerobic microbial treatment technology and [...] Read more.

The offshore oil extraction process generates copious amounts of high-salinity oil-bearing wastewater; at present, treating such wastewater in an efficient and low-consumption manner is a major challenge. In this study, a flat ceramic membrane bioreactor (C−MBR) process combining aerobic microbial treatment technology and ceramic membrane filtration technology was used to treat oil-bearing wastewater. The pilot test results demonstrated the remarkable performance of the combined sequential batch reactor (SBR) and C-MBR process, wherein the chemical oxygen demand (COD) and ammonia nitrogen (NH₄⁺−N) removal rates reached 93% and 98.9%, respectively. Microbial analysis indicated that the symbiosis between Marinobacterium, Marinobacter, and Nitrosomonas might have contributed to simultaneously removing NH₄⁺−N and reducing COD, and the increased enrichment of Nitrosomonas significantly improved the nitrogen removal efficiency. Cleaning ceramic membranes with NaClO solution reduces membrane contamination and membrane cleaning frequency. The combined SBR and C−MBR process is an economical and feasible solution for treating high-salinity oil-bearing wastewater. Based on the pilot application study, the capital expenditure for operating the full-scale combined SBR and C−MBR process was estimated to be 251,717 USD/year, and the unit wastewater treatment cost was 0.21 USD/m³, which saved 62.5% of the energy cost compared to the conventional MBR process. Full article

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Open AccessEditor’s ChoiceArticle

Novel Sandwich-Structured Hollow Fiber Membrane for High-Efficiency Membrane Distillation and Scale-Up for Pilot Validation

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Chakravarthy Gudipati

Membranes 2022, 12(4), 423; https://doi.org/10.3390/membranes12040423 - 14 Apr 2022

Cited by 2 | Viewed by 1884

Abstract

Hollow fiber membranes were produced from a commercial polyvinylidene fluoride (PVDF) polymer, Kynar HSV 900, with a unique sandwich structure consisting of two sponge-like layers connected to the outer and inner skin layers while the middle layer comprises macrovoids. The sponge-like layer allows [...] Read more.

Hollow fiber membranes were produced from a commercial polyvinylidene fluoride (PVDF) polymer, Kynar HSV 900, with a unique sandwich structure consisting of two sponge-like layers connected to the outer and inner skin layers while the middle layer comprises macrovoids. The sponge-like layer allows the membrane to have good mechanical strength even at low skin thickness and favors water vapor transportation during vacuum membrane distillation (VMD). The middle layer with macrovoids helps to significantly reduce the trans-membrane resistance during water vapor transportation from the feed side to the permeate side. Together, these novel structural characteristics are expected to render the PVDF hollow fiber membranes more efficient in terms of vapor flux as well as mechanical integrity. Using the chemistry and process conditions adopted from previous work, we were able to scale up the membrane fabrication from a laboratory scale of 1.5 kg to a manufacturing scale of 50 kg with consistent membrane performance. The produced PVDF membrane, with a liquid entry pressure (LEPw) of >3 bar and a pure water flux of >30 L/m²·hr (LMH) under VMD conditions at 70–80 °C, is perfectly suitable for next-generation high-efficiency membranes for desalination and industrial wastewater applications. The technology translation efforts, including membrane and module scale-up as well as the preliminary pilot-scale validation study, are discussed in detail in this paper. Full article

(This article belongs to the Special Issue Advanced Membrane Technologies for Wastewater Treatment and Recycling)

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Open AccessEditor’s ChoiceReview

Complementary Powerful Techniques for Investigating the Interactions of Proteins with Porous TiO₂ and Its Hybrid Materials: A Tutorial Review

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Membranes 2022, 12(4), 415; https://doi.org/10.3390/membranes12040415 - 11 Apr 2022

Viewed by 1517

Abstract

Understanding the adsorption and interaction between porous materials and protein is of great importance in biomedical and interface sciences. Among the studied porous materials, TiO₂ and its hybrid materials, featuring distinct, well-defined pore sizes, structural stability and excellent biocompatibility, are widely used. [...] Read more.

Understanding the adsorption and interaction between porous materials and protein is of great importance in biomedical and interface sciences. Among the studied porous materials, TiO₂ and its hybrid materials, featuring distinct, well-defined pore sizes, structural stability and excellent biocompatibility, are widely used. In this review, the use of four powerful, synergetic and complementary techniques to study protein-TiO_2-based porous materials interactions at different scales is summarized, including high-performance liquid chromatography (HPLC), atomic force microscopy (AFM), surface-enhanced Raman scattering (SERS), and Molecular Dynamics (MD) simulations. We expect that this review could be helpful in optimizing the commonly used techniques to characterize the interfacial behavior of protein on porous TiO₂ materials in different applications. Full article

(This article belongs to the Special Issue Mixed-Matrix Membranes and Polymeric Membranes)

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Open AccessEditor’s ChoiceArticle

Inhibition of Hydrogen Evolution by a Bifunctional Membrane between Anode and Electrolyte of Aluminum–Air Battery

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Membranes 2022, 12(4), 407; https://doi.org/10.3390/membranes12040407 - 06 Apr 2022

Cited by 3 | Viewed by 1857

Abstract

The hydrogen evolution reaction of the anode is a severe barrier that limits the further commercial application of Al–air batteries. Therefore, this study introduces a bifunctional membrane for the inhibition of hydrogen evolution in Al–air batteries. The reference to Al₂O₃ [...] Read more.

The hydrogen evolution reaction of the anode is a severe barrier that limits the further commercial application of Al–air batteries. Therefore, this study introduces a bifunctional membrane for the inhibition of hydrogen evolution in Al–air batteries. The reference to Al₂O₃@PAN as “bifunctional” means that it has both hydrophobic and anti-corrosion functions. Al₂O₃ can effectively inhibit the migration of hydroxide ions, and PAN is an excellent hydrophobic material. The bifunctional membrane is placed between the aluminum anode and the electrolyte, which can prevent the invasion of excess water and hydroxide ions, thereby inhibiting the hydrogen evolution corrosion of the anode. Electrochemical tests have confirmed that the corrosion inhibition rate of a bifunctional membrane containing 1.82 wt. % Al₂O₃@PAN is as high as 89.24%. The specific capacity of Al–air batteries containing this membrane can reach 1950 mAh/g, and the utilization rate of the aluminum anode has reached 61.2%, which is helpful in reducing the waste of aluminum resources. The results prove that the bifunctional membrane has excellent anti-corrosion properties. Bifunctional membranes can also be used to prevent the corrosion of metals in other fields. Full article

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Biophysical Characterization of Membrane Proteins Embedded in Nanodiscs Using Fluorescence Correlation Spectroscopy

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Membranes 2022, 12(4), 392; https://doi.org/10.3390/membranes12040392 - 31 Mar 2022

Cited by 1 | Viewed by 2885

Abstract

Proteins embedded in biological membranes perform essential functions in all organisms, serving as receptors, transporters, channels, cell adhesion molecules, and other supporting cellular roles. These membrane proteins comprise ~30% of all human proteins and are the targets of ~60% of FDA-approved drugs, yet [...] Read more.

Proteins embedded in biological membranes perform essential functions in all organisms, serving as receptors, transporters, channels, cell adhesion molecules, and other supporting cellular roles. These membrane proteins comprise ~30% of all human proteins and are the targets of ~60% of FDA-approved drugs, yet their extensive characterization using established biochemical and biophysical methods has continued to be elusive due to challenges associated with the purification of these insoluble proteins. In response, the development of nanodisc techniques, such as nanolipoprotein particles (NLPs) and styrene maleic acid polymers (SMALPs), allowed membrane proteins to be expressed and isolated in solution as part of lipid bilayer rafts with defined, consistent nanometer sizes and compositions, thus enabling solution-based measurements. Fluorescence correlation spectroscopy (FCS) is a relatively simple yet powerful optical microscopy-based technique that yields quantitative biophysical information, such as diffusion kinetics and concentrations, about individual or interacting species in solution. Here, we first summarize current nanodisc techniques and FCS fundamentals. We then provide a focused review of studies that employed FCS in combination with nanodisc technology to investigate a handful of membrane proteins, including bacteriorhodopsin, bacterial division protein ZipA, bacterial membrane insertases SecYEG and YidC, Yersinia pestis type III secretion protein YopB, yeast cell wall stress sensor Wsc1, epidermal growth factor receptor (EGFR), ABC transporters, and several G protein-coupled receptors (GPCRs). Full article

(This article belongs to the Special Issue Advanced Research on Structure–Function Relationships of Membrane Proteins)

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Open AccessEditor’s ChoiceArticle

Integration of Nanofiltration and Reverse Osmosis Technologies in Polyphenols Recovery Schemes from Winery and Olive Mill Wastes by Aqueous-Based Processing

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Paulina Tapia-Quirós

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Membranes 2022, 12(3), 339; https://doi.org/10.3390/membranes12030339 - 18 Mar 2022

Cited by 4 | Viewed by 2072

Abstract

More sustainable waste management in the winery and olive oil industries has become a major challenge. Therefore, waste valorization to obtain value-added products (e.g., polyphenols) is an efficient alternative that contributes to circular approaches and sustainable environmental protection. In this work, an integration [...] Read more.

More sustainable waste management in the winery and olive oil industries has become a major challenge. Therefore, waste valorization to obtain value-added products (e.g., polyphenols) is an efficient alternative that contributes to circular approaches and sustainable environmental protection. In this work, an integration scheme was purposed based on sustainable extraction and membrane separation processes, such as nanofiltration (NF) and reverse osmosis (RO), for the recovery of polyphenols from winery and olive mill wastes. Membrane processes were evaluated in a closed-loop system and with a flat-sheet membrane configuration (NF270, NF90, and Duracid as NF membranes, and BW30LE as RO membrane). The separation and concentration efficiency were evaluated in terms of the total polyphenol content (TPC), and by polyphenol families (hydroxybenzoic acids, hydroxycinnamic acids, and flavonoids), using high-performance liquid chromatography. The water trans-membrane flux was dependent on the trans-membrane pressure for the NF and RO processes. NF90 membrane rejected around 91% of TPC for the lees filters extracts while NF270 membrane rejected about 99% of TPC for the olive pomace extracts. Otherwise, RO membranes rejected more than 99.9% of TPC for both types of agri-food wastes. Hence, NF and RO techniques could be used to obtain polyphenol-rich streams, and clean water for reuse purposes. Full article

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Open AccessEditor’s ChoiceArticle

A Novel Methodology to Obtain the Mechanical Properties of Membranes by Means of Dynamic Tests

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Antonia Lima-Rodriguez

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Jose Garcia-Manrique

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Wei Dong

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Antonio Gonzalez-Herrera

Membranes 2022, 12(3), 288; https://doi.org/10.3390/membranes12030288 - 02 Mar 2022

Cited by 2 | Viewed by 1824

Abstract

A new, non-destructive methodology is proposed in this work in order to determine the mechanical properties of membrane using vibro-acoustic tests. This procedure is based on the dynamic analysis of the behavior of the membrane. When the membrane is subjected to a sound [...] Read more.

A new, non-destructive methodology is proposed in this work in order to determine the mechanical properties of membrane using vibro-acoustic tests. This procedure is based on the dynamic analysis of the behavior of the membrane. When the membrane is subjected to a sound excitation it responds by vibrating based on its modal characteristics and this modal parameter is directly related to its mechanical properties. The paper is structured in two parts. First, the theoretical bases of the test are presented. The interaction between the sound waves and the membrane (mechano-acoustic coupling) is complex and requires meticulous study. It was broadly studied by means of numerical simulations. A summary of this study is shown. Aspects, such as the position of the sound source, the measuring points, the dimensions of the membrane, the frequency range, and the magnitudes to be measured, among others, were evaluated. The validity of modal analysis curve-fitting techniques to extract the modal parameter from the data measures was also explored. In the second part, an experimental test was performed to evaluate the validity of the method. A membrane of the same material with three different diameters was measured with the aim of estimating the value of the Young’s modulus. The procedure was applied and satisfactory results were obtained. Additionally, the experiment shed light on aspects that must be taken account in future experiments. Full article

(This article belongs to the Special Issue State-of-the-Art Membrane Science and Technology in the Iberian Peninsula 2021-2022)

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Open AccessEditor’s ChoiceArticle

Elucidation of the Interactions of Reactive Oxygen Species and Antioxidants in Model Membranes Mimicking Cancer Cells and Normal Cells

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Membranes 2022, 12(3), 286; https://doi.org/10.3390/membranes12030286 - 01 Mar 2022

Cited by 1 | Viewed by 1899

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Photosensitizers (PSs) used in photodynamic therapy (PDT) have been developed to selectively destroy tumor cells. However, PSs recurrently reside on the extracellular matrix or affect normal cells in the vicinity, causing side effects. Additionally, the membrane stability of tumor cells and normal cells [...] Read more.

Photosensitizers (PSs) used in photodynamic therapy (PDT) have been developed to selectively destroy tumor cells. However, PSs recurrently reside on the extracellular matrix or affect normal cells in the vicinity, causing side effects. Additionally, the membrane stability of tumor cells and normal cells in the presence of reactive oxygen species (ROS) has not been studied, and the effects of ROS at the membrane level are unclear. In this work, we elucidate the stabilities of model membranes mimicking tumor cells and normal cells in the presence of ROS. The model membranes are constructed according to the degree of saturation in lipids and the bilayers are prepared either in symmetric or asymmetric form. Interestingly, membranes mimicking normal cells are the most vulnerable to ROS, while membranes mimicking tumor cells remain relatively stable. The instability of normal cell membranes may be one cause of the side effects of PDT. Moreover, we also show that ROS levels are controlled by antioxidants, helping to maintain an appropriate amount of ROS when PDT is applied. Full article

(This article belongs to the Special Issue Lipid Membranes and Their Applications)

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