Special Issue "The Role of Androgen Receptor in Prostate Cancer—Revisited"
Deadline for manuscript submissions: 30 November 2023 | Viewed by 201
Interests: nuclear hormone receptors; androgen receptor; glucocorticoid receptor; antiandrogens; glucocorticoids; urothelial cancer; prostate cancer; genitourinary pathology
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Androgens are known to have widespread physiological actions beyond the reproductive system via binding to the androgen receptor which is a member of the nuclear receptor superfamily that functions as a ligand-inducible transcription factor. Meanwhile, the role of the androgen receptor has been widely studied in prostate cancer. Additionally, since its discovery over 80 years ago, androgen deprivation therapy remains the mainstay of medical treatment for advanced prostate cancer. Nonetheless, the exact functions of the androgen receptor in the development and progression of prostate cancer, as well as the castration resistant state primarily following androgen deprivation therapy, are not fully characterized. The aim of this Special Issue is to provide an overview of current preclinical and clinical findings indicating the involvement of androgen receptor signals in prostate cancer. Original research or review articles on signaling related to androgens and/or the androgen receptor in prostate cancer would be most welcome.
Hiroshi Miyamoto, MD, PhD
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- androgen receptor
- prostate cancer
- androgen deprivation therapy
- castration resistance