Effects of Alcoholism on Bone Health
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 115
Special Issue Editors
Interests: alcohol dependence; alcohol-related liver disease; malnutrition
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Alcohol abuse causes a wide range of organic diseases, with a significant impact on quality of life and even survival. In addition to the well-known liver and brain damage, alcohol has a deleterious effect on the musculoskeletal system. Alcohol-related bone damage is caused by multiple pathways, some of which are not yet fully clarified. There is both direct damage due to alcohol and damage related to the release of pro-inflammatory cytokines and reactive oxygen species. This indirect effect is produced by the transfer of enterobacteria into the portal circulation. Lipopolysaccharide from the bacterial wall stimulates Toll-like receptor 4 on hepatic Kupffer cells, which will trigger the inflammatory response. This response produces systemic effects, and lesions at multiple levels have been reported in relation to this pro-inflammatory status. In addition, there are other phenomena in these patients, such as malnutrition or hormonal alterations, that may also contribute. In relation to bone, the main effect is the loss of bone mass due to a decrease in bone synthesis, although there are discordant data regarding whether there is an increase in bone resorption. Multiple molecules (osteokines) that may be involved in the pathogenesis of alcohol-abuse-related bone damage are currently under study.
This Special Issue aims to show, through original research articles, reviews, communications, and perspectives from researchers in related research fields, the current status of the mechanisms involved in alcohol-related bone damage.
Dr. María Candelaria Martín-González
Dr. Onán Pérez-Hernández
Guest Editors
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