Dear Colleagues,

Non-alcoholic fatty liver disease (NAFLD) is a pathological spectrum ranging from simple steatosis to steatohepatitis, in the absence of harmful alcohol consumption, and is considered the hepatic manifestation of the metabolic syndrome. Recent studies indicate that it is closely related to cardiovascular disease, especially thickening of the carotid artery intima-media layer, as a morphostructural manifestation of the presence of subclinical atheromatosis. In relation to pathogenesis, oxidative stress has been identified as the common link between both entities.

Moreover, oxidative stress plays an important role in the development of alcohol-induced liver damage. Thus, alcohol metabolism via alcohol dehydrogenase leads to the formation of acetaldehyde and ROS, increased lipid peroxidation and decreased antioxidant mechanisms.

NAFLD and alcoholic liver disease are associated with increased cardiovascular risk. NAFLD causes a systemic proinflammatory state and increased oxidative stress, leading to endothelial dysfunction and thus increased cardiovascular risk in asymptomatic individuals. Alcohol itself is toxic to the cardiovascular system. Patients who consume large amounts of alcohol can development cardiac arrhythmias, alcoholic dilated cardiomyopathy or hypertension, among others. In alcoholic liver disease, in addition to REDOX imbalance, there is increased gastrointestinal permeability, with the passage of lipopolysaccharide from Gram-negative bacteria into the portal circulation. This lipopolysaccharide stimulates the hepatic Kuppfer cell, triggering intense cytokine release and leading to an underlying proinflammatory situation.

This Special Issue aims to provide a platform for molecular mechanistic research on oxidative stress in liver disease, with a special focus on potential treatments and novel pathogenic pathways involved in cardiovascular risk in patients with liver disease. We warmly welcome your submissions of original papers and reviews based on results from molecular viewpoints.

Dr. María Candelaria Martín-González
Dr. Pedro Abreu-González
Guest Editors

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• non-alcoholic fatty liver disease
• NAFLD
• alcohol liver disease
• cardiovascular risk
• oxidative stress
• ROS
• subclinical atheromatosis
• REDOX imbalance
• antioxidants
• lipid peroxidation
• cardiovascular disease
• metabolic syndrome