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Special Issue "Redox Regulation in Alcoholic Liver Disease"
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 20 June 2023 | Viewed by 3170
Special Issue Editors
Interests: rheumatoid arthritis; rheumatology; arthritis; systemic inflammatory diseases with liver involvement; musculoskeletal disease
Interests: liver disease; alcoholic hepatitis; liver injury; alcohol; alcohol and disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Oxygen is a double edged sword for life. It is a key element for optimal energy production (e.g., aerobic glycolysis, tricarboxylic acid cycle, oxidative phosphorylation), but also a toxic compound, involved in the generation of reactive oxygen species (ROS) able to damage DNA, proteins, and lipids, and also in the formation of reactive nitrogen species (RNS). Oxidative damage activates proinflammatory cytokines production, and, together with RNS, ROS damage mitochondrial enzymatic chain. Mitochondrial damage and proinflammatory cytokines amplify the deleterious effects of ROS, creating a harmful positive feed-back loop, ultimately leading to cell death. Also, lipid peroxidation promotes ferroptosis, another important pathway involved in cell injury, and oxidative damage to histone proteins and/or DNA may lead to altered gene expression. As a defense against the toxic effects of oxygen, several enzymatic pathways (e.g, superoxide dismutases) developed, since probably very early in the evolution of life. Together with other non-enzymatic compounds, such as urate, bilirubin, several vitamins, and reduced glutathione, and with enzymes involved in the maintenance of cell function and DNA repair during oxidative injury, antioxidants are usually in homeostatic balance with oxidative damage. However, chronic exposure to ethanol, by many mechanisms, may alter this delicate equilibrium, leading to accumulation of ROS and to ongoing disease, not only in the liver but also affecting other organs, especially those with highest oxygen consumption, such as muscle, heart and brain.
Despite intensive research in this field many aspects are still poorly understood, including for instance the role of ferroptosis, or that of the acetaldehyde/advanced glycation end-products on oxidative damage, the relation of epigenetic changes induced by alcoholism, among many others, so studies devoted to shed light on any of the still obscure aspects of the mechanisms and consequences of altered redox equilibrium in alcoholic liver disease are strongly welcome.
Contributions need not be limited to the fields mentioned in the keywords. We look forward to your contribution.
Dr. Iván Ferraz-Amaro
Dr. María Candelaria Martín-González
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- alcoholic liver disease
- reactive oxygen species
- reactive nitrogen species
- oxidative damage
- lipid peroxidation
- proinflammatory cytokines
- advanced glycation end-products
- epigenetic changes
- altered redox equilibrium