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Biosensors
Special Issues
Optical Imaging and Biophotonic Sensors (OIBS)
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Optical Imaging and Biophotonic Sensors (OIBS)

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: closed (20 September 2022) | Viewed by 17546

Special Issue Editor

Dr. Shyqyri Haxha

E-Mail Website
Guest Editor
Department of Electronic Engineering Egham, School of Engineering, Physical and Mathematical Sciences, Royal Holloway University of London, Egham TW20 0EX, UK
Interests: optical image sensors; photonic sensors; optoelectronic biosensors; photonic biosensors; biophotonic sensors; optical sensors; photonic crystal based sensors; metamaterial sensors; nanosensors; wearable medical sensor devices; environmental optical sensors; fiber optic sensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Optical Imaging and Biophotonic Sensors (OIBS) research field is experiencing significant development, primarily in bioimaging, optical spectroscopy imaging, biosensors, nanosensors, integrated photonics and optical lab-on-a-chip sensing systems, relying on the state-of-the-art optical and photonic technology, including instrumentation and measurement biophotonics methods and devices as research tools to understand the cellular origin of diseases. These advanced imaging and photonic-based sensor systems offer major multi-functionalities that deliver greatly increased penetration, resolution, simultaneous sensitivity and selectivity and depth of focus operating in remote environments.

The aim of this Special Issue is to explore the advanced progress in research findings and photonics-based engineering technologies related to OIBS for far-reaching applications in imaging, biosensing, environmental, pharmaceutical, medical (using optical imaging spectroscopy), chemical and nano-optic sensors consisting of biologically or biophysically-derived sensing elements.

Contributions may also include different aspects in terms of sensor design, manufacturing, testing and validation. In other words, the aim of this Special Issue is to provide a clear picture of our recent understanding of optics/photonics involved in sensor design and development.

Review articles and regular original research article related to the above sensors contributions are welcome.

You may choose our Joint Special Issue in Sensors.

Dr. Shyqyri Haxha
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Optical imaging sensors
  • Raman spectroscopy imaging
  • Brillouin microscopy imaging
  • Photonic sensors
  • Biosensors
  • Fiber optic sensors
  • Nanosensors
  • Biophotonics
  • Wearable medical nanosensors
  • Optoelectronic sensors.

Published Papers (5 papers)

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Research

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11 pages, 3351 KiB  
Article
Fluorescence-Based Microendoscopic Sensing System for Minimally Invasive In Vivo Bladder Cancer Diagnosis
by Sanghwa Lee, Jeongmin Oh, Minju Cho and Jun Ki Kim
Biosensors 2022, 12(8), 631; https://doi.org/10.3390/bios12080631 - 11 Aug 2022
Cited by 4 | Viewed by 1900
Abstract
Bladder cancer is commonly diagnosed by evaluating the tissue morphology through cystoscopy, and tumor resection is used as the primary treatment approach. However, these methods are limited by lesion site specificity and resection margin, and can thereby fail to detect cancer lesions at [...] Read more.
Bladder cancer is commonly diagnosed by evaluating the tissue morphology through cystoscopy, and tumor resection is used as the primary treatment approach. However, these methods are limited by lesion site specificity and resection margin, and can thereby fail to detect cancer lesions at early stages. Nevertheless, rapid diagnosis without biopsy may be possible through fluorescence sensing. Herein, we describe a minimally invasive imaging system capable of sensing even small tumors through a 1.2 mm diameter flexible fiber bundle microprobe. We demonstrate that this new device can be used for the early diagnosis of bladder cancer in rats. Bladder cancer was induced in rats using the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN), and a togglable filter capable of PpIX fluorescence sensing was installed in the microendoscopic system. Following 5-aminolevulinic acid administration, tissue in the early stages of bladder cancer was successfully identified with fluorescence detection and confirmed with hematoxylin/eosin and ferrochelatase staining. Although the time required for BBN to induce bladder cancer varied between 3 and 4 weeks among the rats, the microendoscopic system allowed the minimally invasive follow-up on cancer development. Full article
(This article belongs to the Special Issue Optical Imaging and Biophotonic Sensors (OIBS))
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12 pages, 4811 KiB  
Article
Ultralow Laser Power Three-Dimensional Superresolution Microscopy Based on Digitally Enhanced STED
by Xiaochun Shen, Luwei Wang, Wei Li, He Wang, Hanqiu Zhou, Yinru Zhu, Wei Yan and Junle Qu
Biosensors 2022, 12(7), 539; https://doi.org/10.3390/bios12070539 - 20 Jul 2022
Cited by 1 | Viewed by 1656
Abstract
The resolution of optical microscopes is limited by the optical diffraction limit; in particular, the axial resolution is much lower than the lateral resolution, which hinders the clear distinction of the three-dimensional (3D) structure of cells. Although stimulated emission depletion (STED) superresolution microscopy [...] Read more.
The resolution of optical microscopes is limited by the optical diffraction limit; in particular, the axial resolution is much lower than the lateral resolution, which hinders the clear distinction of the three-dimensional (3D) structure of cells. Although stimulated emission depletion (STED) superresolution microscopy can break through the optical diffraction limit to achieve 3D superresolution imaging, traditional 3D STED requires high depletion laser power to acquire high-resolution images, which can cause irreversible light damage to biological samples and probes. Therefore, we developed an ultralow laser power 3D STED superresolution imaging method. On the basis of this method, we obtained lateral and axial resolutions of 71 nm and 144 nm, respectively, in fixed cells with 0.65 mW depletion laser power. This method will have broad application prospects in 3D superresolution imaging of living cells. Full article
(This article belongs to the Special Issue Optical Imaging and Biophotonic Sensors (OIBS))
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6 pages, 1132 KiB  
Communication
Multi-Color Two-Photon Microscopic Imaging Based on a Single-Wavelength Excitation
by Wei Yan, Yangrui Huang, Luwei Wang, Jin Li, Yong Guo, Zhigang Yang and Junle Qu
Biosensors 2022, 12(5), 307; https://doi.org/10.3390/bios12050307 - 06 May 2022
Cited by 4 | Viewed by 2009
Abstract
Two-photon probes with broad absorption spectra are beneficial for multi-color two-photon microscopy imaging, which is one of the most powerful tools to study the dynamic processes of living cells. To achieve multi-color two-photon imaging, multiple lasers and detectors are usually required for excitation [...] Read more.
Two-photon probes with broad absorption spectra are beneficial for multi-color two-photon microscopy imaging, which is one of the most powerful tools to study the dynamic processes of living cells. To achieve multi-color two-photon imaging, multiple lasers and detectors are usually required for excitation and signal collection, respectively. However, one makes the imaging system more complicated and costly. Here, we demonstrate a multi-color two-photon imaging method with a single-wavelength excitation by using a signal separation strategy. The method can effectively solve the problem of spectral crosstalk by selecting a suitable filter combination and applying image subtraction. The experimental results show that the two-color and three-color two-photon imaging are achieved with a single femtosecond laser. Furthermore, this method can also be combined with multi-photon imaging technology to reveal more information and interaction in thick biological tissues. Full article
(This article belongs to the Special Issue Optical Imaging and Biophotonic Sensors (OIBS))
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Review

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28 pages, 17364 KiB  
Review
Optical Fiber, Nanomaterial, and THz-Metasurface-Mediated Nano-Biosensors: A Review
by B. M. Azizur Rahman, Charusluk Viphavakit, Ratchapak Chitaree, Souvik Ghosh, Akhilesh Kumar Pathak, Sneha Verma and Natsima Sakda
Biosensors 2022, 12(1), 42; https://doi.org/10.3390/bios12010042 - 14 Jan 2022
Cited by 40 | Viewed by 7955
Abstract
The increasing use of nanomaterials and scalable, high-yield nanofabrication process are revolutionizing the development of novel biosensors. Over the past decades, researches on nanotechnology-mediated biosensing have been on the forefront due to their potential application in healthcare, pharmaceutical, cell diagnosis, drug delivery, and [...] Read more.
The increasing use of nanomaterials and scalable, high-yield nanofabrication process are revolutionizing the development of novel biosensors. Over the past decades, researches on nanotechnology-mediated biosensing have been on the forefront due to their potential application in healthcare, pharmaceutical, cell diagnosis, drug delivery, and water and air quality monitoring. The advancement of nanoscale science relies on a better understanding of theory, manufacturing and fabrication practices, and the application specific methods. The topology and tunable properties of nanoparticles, a part of nanoscale science, can be changed by different manufacturing processes, which separate them from their bulk counterparts. In the recent past, different nanostructures, such as nanosphere, nanorods, nanofiber, core–shell nanoparticles, nanotubes, and thin films, have been exploited to enhance the detectability of labelled or label-free biological molecules with a high accuracy. Furthermore, these engineered-materials-associated transducing devices, e.g., optical waveguides and metasurface-based scattering media, widened the horizon of biosensors over a broad wavelength range from deep-ultraviolet to far-infrared. This review provides a comprehensive overview of the major scientific achievements in nano-biosensors based on optical fiber, nanomaterials and terahertz-domain metasurface-based refractometric, labelled and label-free nano-biosensors. Full article
(This article belongs to the Special Issue Optical Imaging and Biophotonic Sensors (OIBS))
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Other

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33 pages, 3655 KiB  
Systematic Review
Image Quality Improvement Techniques and Assessment Adequacy in Clinical Optoacoustic Imaging: A Systematic Review
by Ioannis Dimaridis, Patmaa Sridharan, Vasilis Ntziachristos, Angelos Karlas and Leontios Hadjileontiadis
Biosensors 2022, 12(10), 901; https://doi.org/10.3390/bios12100901 - 20 Oct 2022
Cited by 6 | Viewed by 2517
Abstract
Optoacoustic imaging relies on the detection of optically induced acoustic waves to offer new possibilities in morphological and functional imaging. As the modality matures towards clinical application, research efforts aim to address multifactorial limitations that negatively impact the resulting image quality. In an [...] Read more.
Optoacoustic imaging relies on the detection of optically induced acoustic waves to offer new possibilities in morphological and functional imaging. As the modality matures towards clinical application, research efforts aim to address multifactorial limitations that negatively impact the resulting image quality. In an endeavor to obtain a clear view on the limitations and their effects, as well as the status of this progressive refinement process, we conduct an extensive search for optoacoustic image quality improvement approaches that have been evaluated with humans in vivo, thus focusing on clinically relevant outcomes. We query six databases (PubMed, Scopus, Web of Science, IEEE Xplore, ACM Digital Library, and Google Scholar) for articles published from 1 January 2010 to 31 October 2021, and identify 45 relevant research works through a systematic screening process. We review the identified approaches, describing their primary objectives, targeted limitations, and key technical implementation details. Moreover, considering comprehensive and objective quality assessment as an essential prerequisite for the adoption of such approaches in clinical practice, we subject 36 of the 45 papers to a further in-depth analysis of the reported quality evaluation procedures, and elicit a set of criteria with the intent to capture key evaluation aspects. Through a comparative criteria-wise rating process, we seek research efforts that exhibit excellence in quality assessment of their proposed methods, and discuss features that distinguish them from works with similar objectives. Additionally, informed by the rating results, we highlight areas with improvement potential, and extract recommendations for designing quality assessment pipelines capable of providing rich evidence. Full article
(This article belongs to the Special Issue Optical Imaging and Biophotonic Sensors (OIBS))
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