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Biomedicines
Special Issues
Researches on Biomaterials for Tissue Engineering and Tissue Regeneration 2.0
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Special Issue "Researches on Biomaterials for Tissue Engineering and Tissue Regeneration 2.0"

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering in Human Health".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 15413

Special Issue Editor

Prof. Dr. Lars-Peter Kamolz

E-Mail Website
Guest Editor
1. Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, 8036 Graz, Austria
2. COREMED—Cooperative Centre for Regenerative Medicine, Joanneum Research GmbH, Neue Stiftingtal Str., 2, A-8010 Graz, Austria
Interests: plastic surgery; burn care; tissue engineering; regenerative medicine; wound healing; outcome measures; high-impact leadership; circular economy; sustainability
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomaterials serve as an integral component of tissue engineering. They are designed to provide an architectural framework that allows for cell growth and tissue regeneration. Tissue engineering is an interdisciplinary field dedicated to the regeneration of functional human tissues. Despite the fact that the body has intrinsic self-healing properties, the extent of repair varies amongst different tissues, and may also be undermined by the severity of injury or disease.

The classic paradigm relies on a combination of biomaterial scaffolds, cells, and bioactive molecules to orchestrate tissue formation and integration within the host environment. An important avenue of tissue engineering is the development of biomaterials that can promote regenerative processes by effectively transporting cell populations and therapeutic agents, as well as providing a structural scaffolding that confers sufficient mechanical properties to tissues. Among a multitude of applications, tissues, such as bone and cartilage, skin and others, have garnered substantial interest from researchers and clinicians. Defects associated with these regions are quite prevalent in society and contribute to a diminished quality of life.

Over the years, many different processing techniques and scaffold designs have been extensively explored and have led to notable improvements in the quality of tissue engineered constructs. This Special Issue welcomes articles that discuss advances in tissue engineering. It is open for basic to clinical research as well as multi-disciplinary approaches.

We cordially invite authors to contribute original research articles or reviews that are focused on, but not limited to, the following:

  • The use of biomaterials in burn care.
  • Regenerative technologies: future trends.
  • Tissue engineering and regenerative technologies in wound care.
  • Biomaterials for bone and cartilage tissue engineering.
  • Functional biomaterials for tissue engineering and regeneration.

Prof. Dr. Lars-Peter Kamolz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • scaffold
  • regeneration
  • cell growth
  • biomarker
  • tissue engineering
  • autoregeneration
  • bioprinting
  • 3D printing
  • wound healing

Related Special Issue

Published Papers (3 papers)

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Review

19 pages, 1786 KiB  
Review
Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders
by
Elisabeth Hofmann
,
Julia Fink
,
Anna-Lisa Pignet
,
Anna Schwarz
,
Marlies Schellnegger
,
Sebastian P. Nischwitz
,
Judith C. J. Holzer-Geissler
,
Lars-Peter Kamolz
and
Petra Kotzbeck
Biomedicines 2023, 11(4), 1056; https://doi.org/10.3390/biomedicines11041056 - 30 Mar 2023
Cited by 4 | Viewed by 5223
Abstract
Skin wound healing is essential to health and survival. Consequently, high amounts of research effort have been put into investigating the cellular and molecular components involved in the wound healing process. The use of animal experiments has contributed greatly to the knowledge of [...] Read more.
Skin wound healing is essential to health and survival. Consequently, high amounts of research effort have been put into investigating the cellular and molecular components involved in the wound healing process. The use of animal experiments has contributed greatly to the knowledge of wound healing, skin diseases, and the exploration of treatment options. However, in addition to ethical concerns, anatomical and physiological inter-species differences often influence the translatability of animal-based studies. Human in vitro skin models, which include essential cellular and structural components for wound healing analyses, would improve the translatability of results and reduce animal experiments during the preclinical evaluation of novel therapy approaches. In this review, we summarize in vitro approaches, which are used to study wound healing as well as wound healing-pathologies such as chronic wounds, keloids, and hypertrophic scars in a human setting. Full article
(This article belongs to the Special Issue Researches on Biomaterials for Tissue Engineering and Tissue Regeneration 2.0)
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17 pages, 1635 KiB  
Review
Modelling the Complexity of Human Skin In Vitro
by
Elisabeth Hofmann
,
Anna Schwarz
,
Julia Fink
,
Lars-Peter Kamolz
and
Petra Kotzbeck
Biomedicines 2023, 11(3), 794; https://doi.org/10.3390/biomedicines11030794 - 06 Mar 2023
Cited by 6 | Viewed by 5203
Abstract
The skin serves as an important barrier protecting the body from physical, chemical and pathogenic hazards as well as regulating the bi-directional transport of water, ions and nutrients. In order to improve the knowledge on skin structure and function as well as on [...] Read more.
The skin serves as an important barrier protecting the body from physical, chemical and pathogenic hazards as well as regulating the bi-directional transport of water, ions and nutrients. In order to improve the knowledge on skin structure and function as well as on skin diseases, animal experiments are often employed, but anatomical as well as physiological interspecies differences may result in poor translatability of animal-based data to the clinical situation. In vitro models, such as human reconstructed epidermis or full skin equivalents, are valuable alternatives to animal experiments. Enormous advances have been achieved in establishing skin models of increasing complexity in the past. In this review, human skin structures are described as well as the fast evolving technologies developed to reconstruct the complexity of human skin structures in vitro. Full article
(This article belongs to the Special Issue Researches on Biomaterials for Tissue Engineering and Tissue Regeneration 2.0)
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19 pages, 2790 KiB  
Review
Polypropylene Pelvic Mesh: What Went Wrong and What Will Be of the Future?
by
Amelia Seifalian
,
Zeinab Basma
,
Alex Digesu
and
Vikram Khullar
Biomedicines 2023, 11(3), 741; https://doi.org/10.3390/biomedicines11030741 - 01 Mar 2023
Cited by 1 | Viewed by 4297
Abstract
Background: Polypropylene (PP) pelvic mesh is a synthetic mesh made of PP polymer used to treat pelvic organ prolapse (POP). Its use has become highly controversial due to reports of serious complications. This research critically reviews the current management options for POP and [...] Read more.
Background: Polypropylene (PP) pelvic mesh is a synthetic mesh made of PP polymer used to treat pelvic organ prolapse (POP). Its use has become highly controversial due to reports of serious complications. This research critically reviews the current management options for POP and PP mesh as a viable clinical application for the treatment of POP. The safety and suitability of PP material were rigorously studied and critically evaluated, with consideration to the mechanical and chemical properties of PP. We proposed the ideal properties of the ‘perfect’ synthetic pelvic mesh with emerging advanced materials. Methods: We performed a literature review using PubMed/Medline, Embase, Cochrane Library (Wiley) databases, and ClinicalTrials.gov databases, including the relevant keywords: pelvic organ prolapse (POP), polypropylene mesh, synthetic mesh, and mesh complications. Results: The results of this review found that although PP is nontoxic, its physical properties demonstrate a significant mismatch between its viscoelastic properties compared to the surrounding tissue, which is a likely cause of complications. In addition, a lack of integration of PP mesh into surrounding tissue over longer periods of follow up is another risk factor for irreversible complications. Conclusions: PP mesh has caused a rise in reports of complications involving chronic pain and mesh exposure. This is due to the mechanical and physicochemical properties of PP mesh. As a result, PP mesh for the treatment of POP has been banned in multiple countries, currently with no alternative available. We propose the development of a pelvic mesh using advanced materials including emerging graphene-based nanocomposite materials. Full article
(This article belongs to the Special Issue Researches on Biomaterials for Tissue Engineering and Tissue Regeneration 2.0)
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